Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models
Nakayama, Ayako, Nagashima, Takeyuki, Nishizono, Yoshihiro, Kuramoto, Kazuyuki, Mori, Kenichi, Homboh, Kazuya, Yuri, Masatoshi, Shimazaki, Masashi
Published in British journal of cancer (23.03.2022)
Published in British journal of cancer (23.03.2022)
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Journal Article
Discovery of 3,5-Dimethylpyridin-4(1H)-one Derivatives as Activators of AMP-Activated Protein Kinase (AMPK)
Kuramoto, Kazuyuki, Sawada, Yuki, Ishibashi, Naoki, Yamada, Tomohiro, Nagashima, Takeyuki, Shin, Takashi
Published in Chemical & pharmaceutical bulletin (01.01.2020)
Published in Chemical & pharmaceutical bulletin (01.01.2020)
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Journal Article
Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer
Kuramoto, Kazuyuki, Yamada, Hiroyoshi, Shin, Takashi, Sawada, Yuki, Azami, Hidenori, Yamada, Tomohiro, Nagashima, Takeyuki, Ohnuki, Kei
Published in Bioorganic & medicinal chemistry (01.03.2020)
Published in Bioorganic & medicinal chemistry (01.03.2020)
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Journal Article
Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity
Kuramoto, Kazuyuki, Sawada, Yuki, Yamada, Tomohiro, Nagashima, Takeyuki, Ohnuki, Kei, Shin, Takashi
Published in Chemical & pharmaceutical bulletin (01.05.2020)
Published in Chemical & pharmaceutical bulletin (01.05.2020)
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Journal Article
Novel Indirect AMP-Activated Protein Kinase Activators : Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity
Kazuyuki Kuramoto, Yuki Sawada, Tomohiro Yamada, Takeyuki Nagashima, Kei Ohnuki, Takashi Shin
Published in Chemical and Pharmaceutical Bulletin (01.05.2020)
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Published in Chemical and Pharmaceutical Bulletin (01.05.2020)
Journal Article
Search for molecular bremsstrahlung radiation signals in Ku band with coincidental operations of radio telescopes with air shower detectors
Ogio, Shoichi, Yamamoto, Tokonatsu, Kuramoto, Kazuyuki, Iijima, Takashi, Akimune, Hidetoshi, Fujii, Toshihiro, Sakurai, Nobuyuki, Fukushima, Masaki, Sagawa, Hiroyuki
Published in EPJ Web of conferences (01.01.2013)
Published in EPJ Web of conferences (01.01.2013)
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Journal Article
New imidazopyridopyrimidine:naphthyridine base-pairing motif, ImNN:NaOO, consisting of a DAAD:ADDA hydrogen bonding pattern, markedly stabilize DNA duplexes
Kuramoto, Kazuyuki, Tarashima, Noriko, Hirama, Yasuyuki, Kikuchi, Yusaku, Minakawa, Noriaki, Matsuda, Akira
Published in Chemical communications (Cambridge, England) (2011)
Published in Chemical communications (Cambridge, England) (2011)
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Journal Article
Four hydrogen-bonding motifs in oligonucleotides
Minakawa, Noriaki, Kuramoto, Kazuyuki, Hikishima, Sadao, Matsuda, Akira
Published in ARKIVOC (27.01.2006)
Published in ARKIVOC (27.01.2006)
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Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity
Imaizumi, Tomoyoshi, Akaiwa, Michinori, Abe, Tomoaki, Nigawara, Takahiro, Koike, Takanori, Satake, Yoshiki, Watanabe, Kazushi, Kaneko, Osamu, Amano, Yasushi, Mori, Kenichi, Yamanaka, Yosuke, Nagashima, Takeyuki, Shimazaki, Masashi, Kuramoto, Kazuyuki
Published in Bioorganic & medicinal chemistry (01.10.2022)
Published in Bioorganic & medicinal chemistry (01.10.2022)
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Journal Article
Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl} prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors
Imaizumi, Tomoyoshi, Shimada, Itsuro, Satake, Yoshiki, Yamaki, Susumu, Koike, Takanori, Nigawara, Takahiro, Kaneko, Osamu, Amano, Yasushi, Mori, Kenichi, Yamanaka, Yosuke, Nakayama, Ayako, Nishizono, Yoshihiro, Shimazaki, Masashi, Nagashima, Takeyuki, Kuramoto, Kazuyuki
Published in Bioorganic & medicinal chemistry (15.01.2024)
Published in Bioorganic & medicinal chemistry (15.01.2024)
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Journal Article
HETEROCYCLIC COMPOUND FOR INDUCING DEGRADATION OF G12V MUTANT KRAS PROTEIN
IMAIZUMI, Tomoyoshi, KAWAMINAMI, Eiji, MORIKAWA, Takahiro, KURAMOTO, Kazuyuki, IMADA, Sunao, KOGANEMARU, Yohei, OKUMURA, Mitsuaki, HAMAGUCHI, Hisao, YOSHINARI, Tomohiro, NISHIZONO, Yoshihiro
Year of Publication 15.02.2024
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Year of Publication 15.02.2024
Patent
HETEROCYCLIC COMPOUND THAT ACTS ON G12D MUTANT KRAS PROTEIN
INAMI HIROSHI, WATANABE HIDEYUKI, YOSHINARI TOMOHIRO, INAMURA KOHEI, NAGASHIMA TAKEYUKI, KAWAGUCHI KENICHI, KURAMOTO KAZUYUKI, TAKAHASHI FUMIE, KAMIKUBO TAKASHI, MORIKAWA TAKAHIRO, ISHIOKA HIROKI, HAMAGUCHI TOSHIO, KAWANAMI EIJI, IMAIZUMI TOMOYOSHI
Year of Publication 23.04.2024
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Year of Publication 23.04.2024
Patent
HETEROCYCLIC COMPOUND FOR INDUCING DEGRADATION OF MUTANT KRAS PROTEIN
FUJIWARA, Yuta, MORIKAWA, Takahiro, KURAMOTO, Kazuyuki, IMADA, Sunao, HAMAGUCHI, Hisao, NISHIZONO, Yoshihiro, ISHIOKA, Hiroki, IMAIZUMI, Tomoyoshi, KAWAMINAMI, Eiji, HONJO, Eriko, KOGANEMARU, Yohei, OKUMURA, Mitsuaki, YOSHINARI, Tomohiro
Year of Publication 08.02.2024
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Year of Publication 08.02.2024
Patent
HETEROCYCLIC COMPOUND THAT ACTS ON G12D MUTANT KRAS PROTEIN
MORIKAWA, Takahiro, KURAMOTO, Kazuyuki, WATANABE, Hideyuki, HAMAGUCHI, Hisao, ISHIOKA, Hiroki, KAWAMINAMI, Eiji, KAWAGUCHI, Kenichi, IMAIZUMI, Tomoyoshi, INAMURA, Kohei, INAMI, Hiroshi, TAKAHASHI, Fumie, KAMIKUBO, Takashi, NAGASHIMA, Takeyuki, YOSHINARI, Tomohiro
Year of Publication 25.01.2024
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Year of Publication 25.01.2024
Patent
G12D 변이 KRAS 단백의 분해를 유도하기 위한 퀴나졸린화합물
WATANABE HIDEYUKI, YOSHINARI TOMOHIRO, INAMURA KOHEI, HAMAGUCHI HISAO, NAGASHIMA TAKEYUKI, KAWAGUCHI KENICHI, KURAMOTO KAZUYUKI, MORIKAWA TAKAHIRO, ISHIOKA HIROKI, IMADA SUNAO, OKUMURA MITSUAKI, IMAIZUMI TOMOYOSHI, KAWAMINAMI EIJI
Year of Publication 17.10.2023
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Year of Publication 17.10.2023
Patent
4-아미노퀴나졸린 화합물
KURIWAKI IKUMI, HAMAGUCHI HISAO, NAGASHIMA TAKEYUKI, KAWAGUCHI KENICHI, KURAMOTO KAZUYUKI, SATO RYO, SEKI YOHEI, MORIKAWA TAKAHIRO, ISHIOKA HIROKI, FUKUDOME HIROKI, IMADA SUNAO, OKUMURA MITSUAKI, IMAIZUMI TOMOYOSHI, KAWAMINAMI EIJI
Year of Publication 17.10.2023
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Year of Publication 17.10.2023
Patent
HETEROCYCLIC COMPOUND FOR INDUCING DEGRADATION OF G12D MUTANT KRAS PROTEIN
ISHIOKA, Hiroki, KAWAGUCHI, Kenichi, KAWAMINAMI, Eiji, IMAIZUMI, Tomoyoshi, MORIKAWA, Takahiro, INAMURA, Kohei, KURAMOTO, Kazuyuki, TAKAHASHI, Fumie, WATANABE, Hideyuki, HAMAGUCHI, Hisao, NAGASHIMA, Takeyuki, YOSHINARI, Tomohiro
Year of Publication 14.09.2023
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Year of Publication 14.09.2023
Patent