Oral levosimendan in amyotrophic lateral sclerosis: a phase II multicentre, randomised, double-blind, placebo-controlled trial
Al-Chalabi, Ammar, Shaw, Pamela, Leigh, P Nigel, van den Berg, Leonard, Hardiman, Orla, Ludolph, Albert, Aho, Valtteri V, Sarapohja, Toni, Kuoppamäki, Mikko
Published in Journal of neurology, neurosurgery and psychiatry (01.10.2019)
Published in Journal of neurology, neurosurgery and psychiatry (01.10.2019)
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Journal Article
Effect of Carbidopa Dose on Levodopa Pharmacokinetics With and Without Catechol-O-Methyltransferase Inhibition in Healthy Subjects
Tuunainen, Johanna, Sjöstedt, Noora, Vahteristo, Mikko, Ellmén, Juha, Kuoppamäki, Mikko, Rouru, Juha, Yliperttula, Marjo
Published in European journal of drug metabolism and pharmacokinetics (2023)
Published in European journal of drug metabolism and pharmacokinetics (2023)
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Journal Article
Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial
Cudkowicz, Merit, Maragakis, Nicholas, Petri, Susanne, van den Berg, Leonard, Aho, Valtteri V, Sarapohja, Toni, Kuoppamäki, Mikko, Garratt, Chris, Al-Chalabi, Ammar, Kiernan, Matthew, Mathers, Susan, Henderson, Robert, Needham, Merrilee, Schultz, David, Löscher, Wolfgang, Mitrovic, Nenad, Rath, Jakob, Damme, Philip Van, De Bleecker, Jan L., Delstanche, Stéphanie, Johnston, Wendy, Zinman, Lorne, O'Connell, Colleen, Matte, Genevieve, Dionne, Annie, Korngut, Lawrence, Turnbull, John, Laaksovirta, Hannu, Jokela, Manu, Tapiola, Tero, Soriani, Marie-Hélène, Couratier, Philippe, Camu, William, Corcia, Philippe, Ludolph, Albert, Großkreutz, Julian, Meyer, Thomas, Boentert, Matthias, Prudlo, Johannes, Untucht, Robert, Hardiman, Orla, Siciliano, Gabriele, Chio', Adriano, Mazzini, Letizia, Inghilleri, Maurizio, Caponnetto, Claudia, Mora, Gabriele, Mora Pardina, Jesús S, Farrero Munoz, Eva, Vázquez Costa, Juan F, Aguera Morales, Eduardo, Varona, Luis, Andersen, Peter, Ingre, Caroline, Johansson, Rune, Radunovic, Aleksandar, Young, Carolyn, Babu, Suma, Shaibani, Aziz, Staff, Nathan, Vu, Tuan, Rivner, Michael, Scelsa, Stephen, Sivakumar, Kumaraswamy, Waheed, Waqar, Heitzman, Daragh, Rana, Sandeep, Pattee, Gary, Bayat, Elham, Kasarskis, Edward, Lange, Dale J, Elliott, Michael, Harris, Brent, Felice, Kevin, Pulley, Michael T, Kwan, Justin, Brown, Martin, Ravits, John, Burford, Matthew, Karam, Chafic, Miller, Timothy, Andrews, Jinsy, Levine, Todd, Locatelli, Eduardo, Wymer, James, Bedlack, Richard, Fee, Dominic, Goyal, Namita, Oskarsson, Bjorn, McCluskey, Leo, Caress, James, Weiss, Michael, Quick, Adam, Bromberg, Mark, Lacomis, David, Goutman, Stephen, Rezania, Kourosh, Guliani, Gaurav, Goslin, Kimberly, Katz, Jonathan S
Published in Lancet neurology (01.10.2021)
Published in Lancet neurology (01.10.2021)
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Journal Article
The effect of different dosing regimens of levodopa/carbidopa/entacapone on plasma levodopa concentrations
Ingman, Kimmo, Naukkarinen, Tarja, Vahteristo, Mikko, Korpela, Irja, Kuoppamäki, Mikko, Ellmén, Juha
Published in European journal of clinical pharmacology (01.03.2012)
Published in European journal of clinical pharmacology (01.03.2012)
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Journal Article
Entacapone and Prostate Cancer Risk in Patients With Parkinson's Disease
Korhonen, Pasi, Kuoppamäki, Mikko, Prami, Tuire, Hoti, Fabian, Christopher, Solomon, Ellmén, Juha, Aho, Valtteri, Vahteristo, Mikko, Pukkala, Eero, Haukka, Jari
Published in Movement disorders (15.04.2015)
Published in Movement disorders (15.04.2015)
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Journal Article
Levosimendan alone and in combination with valsartan prevents stroke in Dahl salt-sensitive rats
Levijoki, Jouko, Kivikko, Matti, Pollesello, Piero, Sallinen, Jukka, Hyttilä-Hopponen, Minja, Kuoppamäki, Mikko, Haasio, Kristiina, Gröhn, Olli, Miettinen, Riitta, Puoliväli, Jukka, Tähtivaara, Leena, Yrjänheikki, Juha, Haapalinna, Antti
Published in European journal of pharmacology (05.03.2015)
Published in European journal of pharmacology (05.03.2015)
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Journal Article
Comparison of pharmacokinetic profile of levodopa throughout the day between levodopa/carbidopa/entacapone and levodopa/carbidopa when administered four or five times daily
Kuoppamäki, Mikko, Korpela, Kirsi, Marttila, Reijo, Kaasinen, Valtteri, Hartikainen, Päivi, Lyytinen, Jukka, Kaakkola, Seppo, Hänninen, Jutta, Löyttyniemi, Eliisa, Kailajärvi, Marita, Ruokoniemi, Päivi, Ellmén, Juha
Published in European journal of clinical pharmacology (01.05.2009)
Published in European journal of clinical pharmacology (01.05.2009)
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3,4-Methylenedioxymethamphetamine (Ecstasy) Inhibits Dyskinesia Expression and Normalizes Motor Activity in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Primates
Iravani, Mahmoud M, Jackson, Michael J, Kuoppamaki, Mikko, Smith, Lance A, Jenner, Peter
Published in The Journal of neuroscience (08.10.2003)
Published in The Journal of neuroscience (08.10.2003)
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Journal Article
Multiple small doses of levodopa plus entacapone produce continuous dopaminergic stimulation and reduce dyskinesia induction in MPTP-treated drug-naïve primates
Smith, Lance A., Jackson, Michael J., Al-Barghouthy, Ghassan, Rose, Sarah, Kuoppamaki, Mikko, Olanow, Warren, Jenner, Peter
Published in Movement disorders (01.03.2005)
Published in Movement disorders (01.03.2005)
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Journal Article
"Progressive delayed-onset postanoxic dystonia" diagnosed with PANK2 mutations 26 years after onset-An update
Kojovic, Maja, Kuoppamäki, Mikko, Quinn, Niall, Bhatia, Kailash P.
Published in Movement disorders (15.12.2010)
Published in Movement disorders (15.12.2010)
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Journal Article
Direct switch from levodopa/benserazide or levodopa/carbidopa to levodopa/carbidopa/entacapone in Parkinson’s disease patients with wearing-off: efficacy, safety and feasibility—an open-label, 6-week study
Eggert, Karla, Skogar, Örjan, Amar, Khaled, Luotonen, Liisa, Kuoppamäki, Mikko, Leinonen, Mika, Nissinen, Helena, Oertel, Wolfgang
Published in Journal of Neural Transmission (01.03.2010)
Published in Journal of Neural Transmission (01.03.2010)
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Journal Article
Switching from levodopa to the long-acting dopamine D2/D3 agonist piribedil reduces the expression of dyskinesia while maintaining effective motor activity in MPTP-treated primates
Smith, Lance A, Jackson, Michael J, Johnston, Louisa, Kuoppamaki, Mikko, Rose, Sarah, Al-Barghouthy, Ghassan, Del Signore, Susanna, Jenner, Peter
Published in Clinical neuropharmacology (01.05.2006)
Published in Clinical neuropharmacology (01.05.2006)
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Journal Article
Oral Levosimendan Increases Cerebral Blood Flow Velocities in Patients with a History of Stroke or Transient Ischemic Attack: A Pilot Safety Study
Kivikko, Matti, MD, PhD, Kuoppamäki, Mikko, MD, PhD, Soinne, Lauri, MD, PhD, Sundberg, Stig, PhD, Pohjanjousi, Pasi, MSc, Ellmen, Juha, PhD, Roine, Risto O., MD, PhD
Published in Current therapeutic research (01.12.2015)
Published in Current therapeutic research (01.12.2015)
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Journal Article
Feasibility and patient acceptability of a commercially available wearable and a smart phone application in identification of motor states in parkinson's disease
Liikkanen, Sammeli, Sinkkonen, Janne, Suorsa, Joni, Kaasinen, Valtteri, Pekkonen, Eero, Kärppä, Mikko, Scheperjans, Filip, Huttunen, Teppo, Sarapohja, Toni, Pesonen, Ullamari, Kuoppamäki, Mikko, Keränen, Tapani
Published in PLOS digital health (01.04.2023)
Published in PLOS digital health (01.04.2023)
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