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Published in Journal of medicinal chemistry (14.06.2007)
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Published in Journal of medicinal chemistry (14.07.2005)
Published in Journal of medicinal chemistry (14.07.2005)
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5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors
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Published in Bioorganic & medicinal chemistry letters (01.09.2020)
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An efficient and scalable synthesis of (2R,αS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol: A potent CETP inhibitor
Wang, Aihua, Zhang, Yan, Lu, Songfeng, Murray, William V., Kuo, Gee-Hong
Published in Journal of heterocyclic chemistry (01.11.2010)
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Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents
Du, Fuyong, Hinke, Simon A., Cavanaugh, Cassandre, Polidori, David, Wallace, Nathanial, Kirchner, Thomas, Jennis, Matthew, Lang, Wensheng, Kuo, Gee-Hong, Gaul, Micheal D., Lenhard, James, Demarest, Keith, Ajami, Nadim J., Liang, Yin, Hornby, Pamela J.
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
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Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors
Kuo, Gee-Hong, Gaul, Micheal D., Liang, Yin, Xu, June Z., Du, Fuyong, Hornby, Pamela, Xu, Guozhang, Qi, Jenson, Wallace, Nathaniel, Lee, Seunghun, Grant, Eugene, Murray, William V., Demarest, Keith
Published in Bioorganic & medicinal chemistry letters (15.04.2018)
Published in Bioorganic & medicinal chemistry letters (15.04.2018)
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Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors
Xu, Guozhang, Gaul, Michael D., Kuo, Gee-Hong, Du, Fuyong, Xu, June Zhi, Wallace, Nathaniel, Hinke, Simon, Kirchner, Thomas, Silva, Jose, Huebert, Norman D., Lee, Seunghun, Murray, William, Liang, Yin, Demarest, Keith
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
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Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform
Rano, Thomas A., Sieber-McMaster, Ellen, Pelton, Patricia D., Yang, Maria, Demarest, Keith T., Kuo, Gee-Hong
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo
Qi, Jenson, Lang, Wensheng, Connelly, Margery A, Du, Fuyong, Liang, Yin, Caldwell, Gary W, Martin, Tonya, Hansen, Michael K, Kuo, Gee-Hong, Gaul, Michael D, Pocai, Alessandro, Lee, Seunghun
Published in Analytical biochemistry (01.05.2017)
Published in Analytical biochemistry (01.05.2017)
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Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors
Wang, Aihua, Prouty, Catherine P., Pelton, Patricia D., Yong, Maria, Demarest, Keith T., Murray, William V., Kuo, Gee-Hong
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
Published in Bioorganic & medicinal chemistry letters (15.02.2010)
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Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors
Zhang, Xuqing, Song, Fengbing, Kuo, Gee-Hong, Xiang, Amy, Gibbs, Alan C., Abad, Marta C., Sun, Weimei, Kuo, Lawrence C., Sui, Zhihua
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
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4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Part 2. Pyridazine-based analogs
Yang, Shyh-Ming, Tang, Yuting, Rano, Thomas, Lu, Huajun, Kuo, Gee-Hong, Gaul, Michael D., Li, Yaxin, Ho, George, Lang, Wensheng, Conway, James G., Liang, Yin, Lenhard, James M., Demarest, Keith T., Murray, William V.
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
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3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3
Zhang, Han-Cheng, Ye, Hong, Conway, Bruce R., Derian, Claudia K., Addo, Michael F., Kuo, Gee-Hong, Hecker, Leonard R., Croll, Diane R., Li, Jian, Westover, Lori, Xu, Jun Z., Look, Richard, Demarest, Keith T., Andrade-Gordon, Patricia, Damiano, Bruce P., Maryanoff, Bruce E.
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition
Connelly, Margery A, Parry, Tom J, Giardino, Edward C, Huang, Zhihong, Cheung, Wai-Man, Chen, Cailin, Cools, Frank, Van der Linde, Henk, Gallacher, David J, Kuo, Gee-Hong, Sarich, Troy C, Demarest, Keith T, Damiano, Bruce P
Published in Journal of cardiovascular pharmacology (01.05.2010)
Published in Journal of cardiovascular pharmacology (01.05.2010)
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Synthesis and Identification of [1,2,4]Thiadiazole Derivatives as a New Series of Potent and Orally Active Dual Agonists of Peroxisome Proliferator-Activated Receptors α and δ
Shen, Lan, Zhang, Yan, Wang, Aihua, Sieber-McMaster, Ellen, Chen, Xiaoli, Pelton, Patricia, Xu, Jun Z, Yang, Maria, Zhu, Peifang, Zhou, Lubing, Reuman, Michael, Hu, Zhiyong, Russell, Ronald, Gibbs, Alan C, Ross, Hamish, Demarest, Keith, Murray, William V, Kuo, Gee-Hong
Published in Journal of medicinal chemistry (09.08.2007)
Published in Journal of medicinal chemistry (09.08.2007)
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Synthesis and Discovery of Macrocyclic Polyoxygenated Bis-7-azaindolylmaleimides as a Novel Series of Potent and Highly Selective Glycogen Synthase Kinase-3β Inhibitors
Kuo, Gee-Hong, Prouty, Catherine, DeAngelis, Alan, Shen, Lan, O'Neill, David J, Shah, Chandra, Connolly, Peter J, Murray, William V, Conway, Bruce R, Cheung, Peter, Westover, Lori, Xu, Jun Z, Look, Richard A, Demarest, Keith T, Emanuel, Stuart, Middleton, Steven A, Jolliffe, Linda, Beavers, Mary Pat, Chen, Xin
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Novel LC/MS/MS and High-Throughput Mass Spectrometric Assays for Monoacylglycerol Acyltransferase Inhibitors
Qi, Jenson, Masucci, John A., Lang, Wensheng, Connelly, Margery A., Caldwell, Gary W., Petrounia, Ioanna, Kirkpatrick, Jennifer, Barnakov, Alexander N., Struble, Geoffrey, Miller, Robyn, Dzordzorine, Keli, Kuo, Gee-Hong, Gaul, Michael, Pocai, Alessandro, Lee, Seunghun
Published in SLAS discovery (01.04.2017)
Published in SLAS discovery (01.04.2017)
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Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARδ agonists
Zhang, Rui, DeAngelis, Alan, Wang, Aihua, Sieber-McMaster, Ellen, Li, Xun, Russell, Ronald, Pelton, Patricia, Xu, Jun, Zhu, Peifang, Zhou, Lubing, Demarest, Keith, Murray, William V., Kuo, Gee-Hong
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
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