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Published in Bioorganic & medicinal chemistry letters (15.03.2014)
Published in Bioorganic & medicinal chemistry letters (15.03.2014)
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Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467
Brady, Patrick B., Sorensen, Bryan K., Risi, Roberto M., Curtin, Michael L., Mantei, Robert A., Florjancic, Alan S., Mastracchio, Anthony, Ji, Cheng, Kunzer, Aaron R., Lai, Chunqiu, Storer, Gregory E., Chan, Vincent S., Henry, Rodger F., Souers, Andrew J., Michaelides, Michael R., Judd, Andrew S., Hansen, T. Matthew
Published in Journal of organic chemistry (17.11.2023)
Published in Journal of organic chemistry (17.11.2023)
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Fesik, Stephen W, Rosenberg, Saul H, Oltersdorf, Tilman, Elmore, Steven W, Shoemaker, Alexander R, Armstrong, Robert C, Augeri, David J, Belli, Barbara A, Bruncko, Milan, Deckwerth, Thomas L, Dinges, Jurgen, Hajduk, Philip J, Joseph, Mary K, Kitada, Shinichi, Korsmeyer, Stanley J, Kunzer, Aaron R, Letai, Anthony, Li, Chi, Mitten, Michael J, Nettesheim, David G, Ng, ShiChung, Nimmer, Paul M, O'Connor, Jacqueline M, Oleksijew, Anatol, Petros, Andrew M, Reed, John C, Shen, Wang, Tahir, Stephen K, Thompson, Craig B, Tomaselli, Kevin J, Wang, Baole, Wendt, Michael D, Zhang, Haichao
Published in Nature (02.06.2005)
Published in Nature (02.06.2005)
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Discovery of A‑1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL‑XL Inhibitor
Wang, Le, Doherty, George A, Judd, Andrew S, Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R, Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R, Wang, Xilu, Wendt, Michael D, Flygare, John A, Catron, Nathaniel D, Judge, Russell A, Park, Chang H, Shekhar, Shashank, Phillips, Darren C, Nimmer, Paul, Smith, Morey L, Tahir, Stephen K, Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N, Mitten, Michael J, Boghaert, Erwin R, Gao, Wenqing, Kovar, Peter, Choo, Edna F, Diaz, Dolores, Fairbrother, Wayne J, Elmore, Steven W, Sampath, Deepak, Leverson, Joel D, Souers, Andrew James
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Discovery and Design of Novel HSP90 Inhibitors Using Multiple Fragment-based Design Strategies
Huth, Jeffrey R., Park, Chang, Petros, Andrew M., Kunzer, Aaron R., Wendt, Michael D., Wang, Xilu, Lynch, Christopher L., Mack, Jamey C., Swift, Kerry M., Judge, Russell A., Chen, Jun, Richardson, Paul L., Jin, Sha, Tahir, Stephen K., Matayoshi, Edward D., Dorwin, Sarah A., Ladror, Uri S., Severin, Jean M., Walter, Karl A., Bartley, Diane M., Fesik, Stephen W., Elmore, Steven W., Hajduk, Philip J.
Published in Chemical biology & drug design (01.07.2007)
Published in Chemical biology & drug design (01.07.2007)
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Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WANG GARY T, HASVOLD LISA, HANSEN TODD M, WANG LE, SONG XIAOHONG, DOHERTY GEORGE, MANTEI ROBERT, BRUNCKO MILAN, SULLIVAN GERARD, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, ELMORE STEVEN, WENDT MICHAEL, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 05.09.2023
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Year of Publication 05.09.2023
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Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WANG GARY T, HASVOLD LISA, HANSEN TODD M, WANG LE, SONG XIAOHONG, DOHERTY GEORGE, MANTEI ROBERT, BRUNCKO MILAN, SULLIVAN GERARD, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, ELMORE STEVEN, WENDT MICHAEL, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 22.11.2019
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Year of Publication 22.11.2019
Patent
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WANG GARY T, HASVOLD LISA, HANSEN TODD M, WANG LE, SONG XIAOHONG, DOHERTY GEORGE, MANTEI ROBERT, BRUNCKO MILAN, SULLIVAN GERARD, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, ELMORE STEVEN, WENDT MICHAEL, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 22.07.2019
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Year of Publication 22.07.2019
Patent
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WANG GARY T, HASVOLD LISA, HANSEN TODD M, WANG LE, SONG XIAOHONG, DOHERTY GEORGE, MANTEI ROBERT, BRUNCKO MILAN, SULLIVAN GERARD, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, ELMORE STEVEN, WENDT MICHAEL, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 20.11.2018
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Year of Publication 20.11.2018
Patent
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X-L Inhibitor
Wang, Le, Doherty, George A., Judd, Andrew S., Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R., Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R., Wang, Xilu, Wendt, Michael D., Flygare, John A., Catron, Nathaniel D., Judge, Russell A., Park, Chang H., Shekhar, Shashank, Phillips, Darren C., Nimmer, Paul, Smith, Morey L., Tahir, Stephen K., Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N., Mitten, Michael J., Boghaert, Erwin R., Gao, Wenqing, Kovar, Peter, Choo, Edna F., Diaz, Dolores, Fairbrother, Wayne J., Elmore, Steven W., Sampath, Deepak, Leverson, Joel D., Souers, Andrew James
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WANG GARY T, HASVOLD LISA, HANSEN TODD M, WANG LE, SONG XIAOHONG, DOHERTY GEORGE, MANTEI ROBERT, BRUNCKO MILAN, SULLIVAN GERARD, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, ELMORE STEVEN, WENDT MICHAEL, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 10.05.2018
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Year of Publication 10.05.2018
Patent
BCL XL BCL XL INHIBITORY COMPOUNDS HAVING LOW CELL PERMEABILITY AND ANTIBODY DRUG CONJUGATES INCLUDING THE SAME
CULLEN STEVE C, WELCH DENNIE S, SONG XIAOHONG, BENNETT NATHAN B, DOHERTY GEORGE, BOGHAERT ERWIN R, SULLIVAN GERARD M, MARIN VIOLETA L, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, SHEN XIAOQIANG, WENDT MICHAEL D, HAIGHT ANTHONY R, KUNZER AARON R, FREY ROBIN R, ACKLER SCOTT L, JUDD ANDREW S
Year of Publication 16.08.2017
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Year of Publication 16.08.2017
Patent
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WANG GARY T, HASVOLD LISA, HANSEN TODD M, WANG LE, SONG XIAOHONG, DOHERTY GEORGE, MANTEI ROBERT, BRUNCKO MILAN, SULLIVAN GERARD, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, ELMORE STEVEN, WENDT MICHAEL, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 04.04.2017
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Year of Publication 04.04.2017
Patent
Sulfonamide derivatives as Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
MANTEI ROBERT A, WANG GARY T, PARK CHANG H, HASVOLD LISA, PARK, CHEOL MIN, WANG LE, SONG XIAOHONG, ELMORE STEVEN W, BRUNCKO MILAN, SULLIVAN GERARD M, SOUERS ANDREW J, WANG XILU, MCCLELLAN WILLIAM J, TAO ZHI FU, PETROS ANDREW M, WENDT MICHAEL D, DOHERTY GEORGE A, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 18.01.2017
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Year of Publication 18.01.2017
Patent
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
MANTEI ROBERT A, WANG GARY T, PARK CHANG H, HASVOLD LISA, PARK, CHEOL MIN, WANG LE, DAI YUJIA, SONG XIAOHONG, ELMORE STEVEN W, BRUNCKO MILAN, SULLIVAN GERARD M, SOUERS ANDREW J, WANG XILU, MCCLELLAN WILLIAM J, TAO ZHI FU, PETROS ANDREW M, WENDT MICHAEL D, DOHERTY GEORGE A, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 07.12.2016
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Year of Publication 07.12.2016
Patent
APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
PARK CHEOL MIN, SULLIVAN GERARD, SOUERS ANDREW J, ELMORE STEVEN, WENDT MICHAEL, DING HONG, HEXAMER LAURA, KUNZER AARON R
Year of Publication 24.04.2013
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Year of Publication 24.04.2013
Patent