A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors
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Published in Journal of medicinal chemistry (15.03.2001)
Published in Journal of medicinal chemistry (15.03.2001)
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An MTP Inhibitor that Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits
Wetterau, John R., Gregg, Richard E., Harrity, Thomas W., Arbeeny, Cynthia, Cap, Michael, Connolly, Fergal, Chu, Ching-Hsuen, George, Rocco J., Gordon, David A., Jamil, Haris, Jolibois, Kern G., Kunselman, Lori K., Lan, Shih-Jung, Maccagnan, Thomas J., Ricci, Beverly, Yan, Mujing, Young, Douglas, Chen, Ying, Fryszman, Olga M., Janette V. H. Logan, Musial, Christa L., Poss, Michael A., Robl, Jeffrey A., Simpkins, Ligaya M., Slusarchyk, William A., Sulsky, Richard, Taunk, Prakash, Magnin, David R., Tino, Joseph A., Lawrence, R. Michael, Dickson, John K., Biller, Scott A.
Published in Science (American Association for the Advancement of Science) (23.10.1998)
Published in Science (American Association for the Advancement of Science) (23.10.1998)
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Amphotericin B lipid complex therapy of experimental fungal infections in mice
CLARK, J. M, WHITNEY, R. R, OLSEN, S. J, GEORGE, R. J, SWERDEL, M. R, KUNSELMAN, L, BONNER, D. P
Published in Antimicrobial Agents and Chemotherapy (01.04.1991)
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Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo
Ciosek, C P, Magnin, D R, Harrity, T W, Logan, J V, Dickson, J K, Gordon, E M, Hamilton, K A, Jolibois, K G, Kunselman, L K, Lawrence, R M
Published in The Journal of biological chemistry (25.11.1993)
Published in The Journal of biological chemistry (25.11.1993)
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α-Phosphonosulfonic Acids: Potent and Selective Inhibitors of Squalene Synthase
Magnin, David R, Biller, Scott A, Chen, Ying, Dickson, John K, Fryszman, Olga M, Lawrence, R. Michael, Logan, Janette V. H, Sieber-McMaster, Ellen S, Sulsky, Richard B, Traeger, Sarah C, Hsieh, Dolly C, Lan, Shih-Jung, Rinehart, J. Kent, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A, Ciosek, Carl P
Published in Journal of medicinal chemistry (02.02.1996)
Published in Journal of medicinal chemistry (02.02.1996)
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Orally Active Squalene Synthase Inhibitors: Bis((acyloxy)alkyl) Prodrugs of the α-Phosphonosulfonic Acid Moiety
Dickson, John K, Biller, Scott A, Magnin, David R, Petrillo, Edward W, Hillyer, John W, Hsieh, Dolly C, Lan, Shih-Jung, Rinehart, J. Kent, Gregg, Richard E, Harrity, Thomas W, Jolibois, Kern G, Kalinowski, Stephen S, Kunselman, Lori K, Mookhtiar, Kasim A, Ciosek, Carl P
Published in Journal of medicinal chemistry (02.02.1996)
Published in Journal of medicinal chemistry (02.02.1996)
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1,1-Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate
Magnin, David R, Dickson, John K, Logan, Janette V, Lawrence, R. Michael, Chen, Ying, Sulsky, Richard B, Ciosek, Carl P, Biller, Scott A, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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Muraglitazar, a Novel Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves β-Cell Function in db/db Mice
HARRITY, Thomas, FARRELLY, Dennis, WEI WANG, HAO ZHANG, FENDERSON, William, CHEN, Sean, DEVASTHALE, Pratik, JEON, Yoon, SEETHALA, Ramakrishna, YANG, Wen-Pin, REN, Jimmy, MIN ZHOU, TIEMAN, Aaron, RYONO, Denis, BILLER, Scott, MOOKHTIAR, Kasim A, WETTERAU, John, GREGG, Richard, CHENG, Peter T, HARIHARAN, Narayanan, CUIXIA CHU, KUNSELMAN, Lori, LIQUN GU, PONTICIELLO, Randolph, CAP, Michael, FUCHENG QU, CHUNNING SHAO
Published in Diabetes (New York, N.Y.) (01.01.2006)
Published in Diabetes (New York, N.Y.) (01.01.2006)
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5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP
Sulsky, Richard, Robl, Jeffrey A., Biller, Scott A., Harrity, Thomas W., Wetterau, John, Connolly, Fergal, Jolibois, Kern, Kunselman, Lori
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
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Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists
Wang, Wei, Devasthale, Pratik, Farrelly, Dennis, Gu, Liqun, Harrity, Thomas, Cap, Michael, Chu, Cuixia, Kunselman, Lori, Morgan, Nathan, Ponticiello, Randy, Zebo, Rachel, Zhang, Litao, Locke, Kenneth, Lippy, Jonathan, O'Malley, Kevin, Hosagrahara, Vinayak, Zhang, Lisa, Kadiyala, Pathanjali, Chang, Chiehying, Muckelbauer, Jodi, Doweyko, Arthur M, Zahler, Robert, Ryono, Denis, Hariharan, Narayanan, Cheng, Peter T W
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents
Magnin, David R, Biller, Scott A, Wetterau, John, Robl, Jeffrey A, Dickson, John K, Taunk, Prakash, Harrity, Thomas W, Lawrence, R.Michael, Sun, C.-Q, Wang, Tammy, Logan, Janette, Fryszman, Olga, Connolly, Fergal, Jolibois, Kern, Kunselman, Lori
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
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Enantioselective Synthesis of α-Phosphono Sulfonate Squalene Synthase Inhibitors: Chiral Recognition in the Interactions of an α-Phosphono Sulfonate Inhibitor with Squalene Synthase
Lawrence, R. Michael, Biller, Scott A, Dickson, John K, Logan, Janette V. H, Magnin, David R, Sulsky, Richard B, DiMarco, John D, Gougoutas, Jack Z, Beyer, Barbara D, Taylor, Susan C, Lan, Shih-Jung, Ciosek, Carl P, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Slusarchyk, Dorothy A
Published in Journal of the American Chemical Society (20.11.1996)
Published in Journal of the American Chemical Society (20.11.1996)
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