Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors
Ho, Koc-Kan, Parnell, K. Mark, Yuan, Yi, Xu, Yong, Kultgen, Steven G, Hamblin, Steven, Hendrickson, Thomas F, Luo, Bai, Foulks, Jason M, McCullar, Michael V, Kanner, Steven B
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
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Journal Article
Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836
Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Ardzinski, Andrzej, Stever, Kim, Dorsey, Bruce D., Mesaros, Eugen F., Thi, Emily P., Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lee, Amy C. H., Olland, Andrea, Suto, Robert K., Sofia, Michael J.
Published in Journal of medicinal chemistry (04.09.2024)
Published in Journal of medicinal chemistry (04.09.2024)
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Journal Article
Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA
Liu, Fei, Lee, Amy C. H, Guo, Fang, Kondratowicz, Andrew S, Micolochick Steuer, Holly M, Miller, Angela, Bailey, Lauren D, Wang, Xiaohe, Chen, Shuai, Kultgen, Steven G, Cuconati, Andrea, Cole, Andrew G, Gotchev, Dimitar, Dorsey, Bruce D, Rijnbrand, Rene, Lam, Angela M, Sofia, Michael J, Gao, Min
Published in Journal of virology (25.08.2021)
Published in Journal of virology (25.08.2021)
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Journal Article
Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506
Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Quintero, Jorge G., Yi Fan, Kristi, Ardzinski, Andrzej, Stever, Kim, Dorsey, Bruce D., Phelps, Janet R., Lee, Amy C.H., Thi, Emily P., Chiu, Tim, Tang, Sunny, Horanyi, Peter S., Mayclin, Stephen J., Harasym, Troy O., Sofia, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.10.2023)
Published in Bioorganic & medicinal chemistry letters (01.10.2023)
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Journal Article
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein
Mani, Nagraj, Cole, Andrew G., Phelps, Janet R., Ardzinski, Andrzej, Burns, Robbin, Chiu, Tim, Cuconati, Andrea, Dorsey, Bruce D., Evangelista, Ellen, Fan, Kristi, Guo, Fang, Harasym, Troy O., Kadhim, Salam, Kowalski, Roseann, Kultgen, Steven G., Lee, Amy C.H., Li, Alice H., Majeski, Sara A., Miller, Angela, Pasetka, Chris, Reid, Stephen P., Rijnbrand, Rene, Micolochick Steuer, Holly M., Stever, Kim, Tang, Sunny, Teng, Xiaowei, Wang, Xiaohe, Sofia, Michael J.
Published in Antiviral research (01.01.2022)
Published in Antiviral research (01.01.2022)
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Journal Article
Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators
Mesaros, Eugen F., Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Dugan, Benjamin J., Ardzinski, Andrzej, Stever, Kim, Micolochick Steuer, Holly M., Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lam, Angela M., Thi, Emily P., Dorsey, Bruce D., Sofia, Michael J.
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
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Journal Article
The identification of highly efficacious functionalised tetrahydrocyclopenta[]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly
Cole, Andrew G, Kultgen, Steven G, Mani, Nagraj, Ardzinski, Andrzej, Fan, Kristi Yi, Thi, Emily P, Dorsey, Bruce D, Stever, Kim, Chiu, Tim, Tang, Sunny, Daly, Owen, Phelps, Janet R, Harasym, Troy, Olland, Andrea, Suto, Robert K, Sofia, Michael J
Published in MedChemComm (23.03.2022)
Published in MedChemComm (23.03.2022)
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Journal Article
Synthesis and Biological Evaluation of Pyrazolo[1,5‑a]pyrimidine Compounds as Potent and Selective Pim‑1 Inhibitors
Xu, Yong, Brenning, Benjamin G, Kultgen, Steven G, Foulks, Jason M, Clifford, Adrianne, Lai, Shuping, Chan, Ashley, Merx, Shannon, McCullar, Michael V, Kanner, Steven B, Ho, Koc-Kan
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Journal Article
Discovery of C‑Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV‑2
Mesaros, Eugen F., Dugan, Benjamin J., Gao, Min, Sheraz, Muhammad, McGovern-Gooch, Kayleigh, Xu, Fran, Fan, Kristi Yi, Nguyen, Duyan, Kultgen, Steven G., Lindstrom, Aaron, Stever, Kim, Tercero, Breanna, Binder, Randall J., Liu, Fei, Micolochick Steuer, Holly M., Mani, Nagraj, Harasym, Troy O., Thi, Emily P., Cuconati, Andrea, Dorsey, Bruce D., Cole, Andrew G., Lam, Angela M., Sofia, Michael J.
Published in ACS infectious diseases (10.05.2024)
Published in ACS infectious diseases (10.05.2024)
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Journal Article
Discovery of novel quinolinone adenosine A2B antagonists
MCGUINNESS, Brian F, HO, Koc-Kan, ROGERS, W. Lynn, WEBB, Maria, JUXING YIN, YAN JIANG, TAILONG LI, HAO YAN, KONGHUA JING, SHENGTING ZHANG, KANAK KANTI MAJUMDAR, SRIVASTAVA, Vikash, STAUFFER, Tara M, SAHA, Samiran, ROKOSZ, Laura L, MANNAVA, Neelima, KULTGEN, Steven G, SAIONZ, Kurt, KLON, Anthony, WEIQING CHEN, DESAI, Hema
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Journal Article
Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model
Ho, Koc-Kan, Beasley, James R., Belanger, Laura, Black, Darcey, Chan, Jui-Hsiang, Dunn, David, Hu, Bing, Klon, Anthony, Kultgen, Steven G., Ohlmeyer, Michael, Parlato, Susan M., Ray, Peter C., Pham, Quynhchi, Rong, Yajing, Roughton, Andrew L., Walker, Tiffany L., Wright, Jane, Xu, Kai, Xu, Yan, Zhang, Limei, Webb, Maria
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
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Journal Article
Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist
Brown, Angus R., Bosies, Michael, Cameron, Helen, Clark, John, Cowley, Angela, Craighead, Mark, Elmore, Moira A., Firth, Alistair, Goodwin, Richard, Goutcher, Susan, Grant, Emma, Grassie, Morag, Grove, Simon J.A., Hamilton, Niall M., Hampson, Hannah, Hillier, Alison, Ho, Koc-Kan, Kiczun, Michael, Kingsbury, Celia, Kultgen, Steven G., Littlewood, Peter T.A., Lusher, Scott J., MacDonald, Susan, McIntosh, Lorraine, McIntyre, Theresa, Mistry, Ashvin, Morphy, J. Richard, Nimz, Olaf, Ohlmeyer, Michael, Pick, Jack, Rankovic, Zoran, Sherborne, Brad, Smith, Alasdair, Speake, Michael, Spinks, Gayle, Thomson, Fiona, Watson, Lynn, Weston, Mark
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
치환된 1-아릴-1'-헤테로아릴 화합물, 치환된 1,1'-비헤테로아릴 화합물 및 이를 사용하는 방법
KAKARLA RAMESH, AHUJA VIJAY, OZTURK SEYMA, KULTGEN STEVEN G, HEFFERNAN GAVIN D, DORSEY BRUCE D, QUINTERO JORGE, NGUYEN DUYAN, COLE ANDREW G, FAN YI, SOFIA MICHAEL J
Year of Publication 26.02.2024
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Year of Publication 26.02.2024
Patent
치환된 트리사이클릭 아미드, 이의 유사체, 및 이를 사용하는 방법
DUGAN BENJAMIN J, MESAROS EUGEN F, KULTGEN STEVEN G, DORSEY BRUCE D, COLE ANDREW G, FAN YI, SOFIA MICHAEL J
Year of Publication 25.01.2023
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Year of Publication 25.01.2023
Patent
Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists
Ho, Koc-Kan, Auld, Douglas S., Bohnstedt, Adolph C., Conti, Paolo, Dokter, Wim, Erickson, Shawn, Feng, Daming, Inglese, Jim, Kingsbury, Celia, Kultgen, Steven G., Liu, Rong-Qiang, Masterson, Christopher M., Ohlmeyer, Michael, Rong, Yajing, Rooseboom, Martijn, Roughton, Andrew, Samama, Philippe, Smit, Martin-Jan, Son, Ellen, van der Louw, Jaap, Vogel, Gerard, Webb, Maria, Wijkmans, Jac, You, Ming
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
Published in Bioorganic & medicinal chemistry letters (15.05.2006)
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Journal Article
Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis
Guo, Tao, Adang, Anton E.P., Dong, Guizhen, Fitzpatrick, Dan, Geng, Peng, Ho, Koc-Kan, Jibilian, Charles H., Kultgen, Steven G., Liu, Ruiyan, McDonald, Edward, Saionz, Kurt W., Valenzano, Kenneth J., van Straten, Nicole C.R., Xie, Dan, Webb, Maria L.
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
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Journal Article
Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis
Guo, Tao, Adang, Anton E.P., Dolle, Roland E., Dong, Guizhen, Fitzpatrick, Dan, Geng, Peng, Ho, Koc-Kan, Kultgen, Steven G., Liu, Ruiyan, McDonald, Edward, McGuinness, Brian F., Saionz, Kurt W., Valenzano, Kenneth J., van Straten, Nicole C.R., Xie, Dan, Webb, Maria L.
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
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Journal Article
2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors
Ho, Koc-Kan, Appell, Kenneth C., Baldwin, John J., Bohnstedt, Adolph C., Dong, Guizhen, Guo, Tao, Horlick, Robert, Islam, Khondaker R., Kultgen, Steven G., Masterson, Christopher M., McDonald, Edward, McMillan, Kirk, Morphy, J.Richard, Rankovic, Zoran, Sundaram, Hardy, Webb, Maria
Published in Bioorganic & medicinal chemistry letters (19.01.2004)
Published in Bioorganic & medicinal chemistry letters (19.01.2004)
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Journal Article
Preclinical and Clinical Antiviral Characterization of AB-836, a Potent Capsid Assembly Modulator Against Hepatitis B Virus
Lam, Angela M., Mani, Nagraj, Ardzinski, Andrzej, Stever, Kim, Cuconati, Andrea, Micolochick Steuer, Holly, Thi, Emily P., Graves, Ingrid E., Espiritu, Christine L., Mesaros, Eugen, Kultgen, Steven G., Fan, Kristi, Cole, Andrew G., Harasym, Troy O., Rijnbrand, Rene, Brown, Joanne, Eley, Timothy, Varughese, Tilly, Gane, Edward, Picchio, Gaston, Sims, Karen D., Sofia, Michael J.
Published in Antiviral research (01.09.2024)
Published in Antiviral research (01.09.2024)
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Journal Article
Preclinical anti-tumor activity of small-molecule oral PD-L1 checkpoint inhibitors
Thi, Emily P., Cole, Andrew G., Heffernan, Gavin, Iott, Christina L., Ozturk, Seyma, Ganchua, Sharie C., Nguyen, Dan, Graves, Ingrid, Quintero, Jorge G., Stever, Kim, Fan, Kristi, Ahuja, Vijay, Kultgen, Steven G., Shubina, Maria, Liu, Boya, Tang, Sunny, Harasym, Troy, Lam, Angela M., Sofia, Michael J.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article