Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
Drost, Jarno, van Boxtel, Ruben, Blokzijl, Francis, Mizutani, Tomohiro, Sasaki, Nobuo, Sasselli, Valentina, de Ligt, Joep, Behjati, Sam, Grolleman, Judith E., van Wezel, Tom, Nik-Zainal, Serena, Kuiper, Roland P., Cuppen, Edwin, Clevers, Hans
Published in Science (American Association for the Advancement of Science) (13.10.2017)
Published in Science (American Association for the Advancement of Science) (13.10.2017)
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A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer
Weren, Robbert D A, Ligtenberg, Marjolijn J L, Kets, C Marleen, de Voer, Richarda M, Verwiel, Eugène T P, Spruijt, Liesbeth, van Zelst-Stams, Wendy A G, Jongmans, Marjolijn C, Gilissen, Christian, Hehir-Kwa, Jayne Y, Hoischen, Alexander, Shendure, Jay, Boyle, Evan A, Kamping, Eveline J, Nagtegaal, Iris D, Tops, Bastiaan B J, Nagengast, Fokko M, Geurts van Kessel, Ad, van Krieken, J Han J M, Kuiper, Roland P, Hoogerbrugge, Nicoline
Published in Nature genetics (01.06.2015)
Published in Nature genetics (01.06.2015)
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Journal Article
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
Jansen, Joop H, Nikoloski, Gorica, Langemeijer, Saskia M C, Kuiper, Roland P, Knops, Ruth, Massop, Marion, Tönnissen, Evelyn R L T M, van der Heijden, Adrian, Scheele, Theresia N, Vandenberghe, Peter, de Witte, Theo, van der Reijden, Bert A
Published in Nature genetics (01.08.2010)
Published in Nature genetics (01.08.2010)
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Journal Article
Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood
Achatz, Maria Isabel, Porter, Christopher C, Brugières, Laurence, Druker, Harriet, Frebourg, Thierry, Foulkes, William D, Kratz, Christian P, Kuiper, Roland P, Hansford, Jordan R, Hernandez, Hector Salvador, Nathanson, Katherine L, Kohlmann, Wendy K, Doros, Leslie, Onel, Kenan, Schneider, Kami Wolfe, Scollon, Sarah R, Tabori, Uri, Tomlinson, Gail E, Evans, D Gareth R, Plon, Sharon E
Published in Clinical cancer research (01.07.2017)
Published in Clinical cancer research (01.07.2017)
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Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia
Irving, Julie A.E., Enshaei, Amir, Parker, Catriona A., Sutton, Rosemary, Kuiper, Roland P., Erhorn, Amy, Minto, Lynne, Venn, Nicola C., Law, Tamara, Yu, Jiangyan, Schwab, Claire, Davies, Rosanna, Matheson, Elizabeth, Davies, Alysia, Sonneveld, Edwin, den Boer, Monique L., Love, Sharon B., Harrison, Christine J., Hoogerbrugge, Peter M., Revesz, Tamas, Saha, Vaskar, Moorman, Anthony V.
Published in Blood (18.08.2016)
Published in Blood (18.08.2016)
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Journal Article
Acquired mutations in TET2 are common in myelodysplastic syndromes
Jansen, Joop H, Langemeijer, Saskia M C, Kuiper, Roland P, Berends, Marieke, Knops, Ruth, Aslanyan, Mariam G, Massop, Marion, Stevens-Linders, Ellen, van Hoogen, Patricia, van Kessel, Ad Geurts, Raymakers, Reinier A P, Kamping, Eveline J, Verhoef, Gregor E, Verburgh, Estelle, Hagemeijer, Anne, Vandenberghe, Peter, de Witte, Theo, van der Reijden, Bert A
Published in Nature genetics (01.07.2009)
Published in Nature genetics (01.07.2009)
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Journal Article
TRIM28 haploinsufficiency predisposes to Wilms tumor
Diets, Illja J., Hoyer, Juliane, Ekici, Arif B., Popp, Bernt, Hoogerbrugge, Nicoline, Reijmersdal, Simon V., Bhaskaran, Rajith, Hadjihannas, Michel, Vasileiou, Georgia, Thiel, Christian T., Seven, Didem, Uebe, Steffen, Ilencikova, Denisa, Waanders, Esmé, Mavinkurve‐Groothuis, Annelies M.C., Roeleveld, Nel, Krijger, Ronald R., Wegert, Jenny, Graf, Norbert, Vokuhl, Christian, Agaimy, Abbas, Gessler, Manfred, Reis, André, Kuiper, Roland P., Jongmans, Marjolijn C.J., Metzler, Markus
Published in International journal of cancer (15.08.2019)
Published in International journal of cancer (15.08.2019)
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Journal Article
Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival
Katerndahl, Casey D S, Heltemes-Harris, Lynn M, Willette, Mark J L, Henzler, Christine M, Frietze, Seth, Yang, Rendong, Schjerven, Hilde, Silverstein, Kevin A T, Ramsey, Laura B, Hubbard, Gregory, Wells, Andrew D, Kuiper, Roland P, Scheijen, Blanca, van Leeuwen, Frank N, Müschen, Markus, Kornblau, Steven M, Farrar, Michael A
Published in Nature immunology (01.06.2017)
Published in Nature immunology (01.06.2017)
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IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study
Li, Yunlei, Buijs-Gladdines, Jessica G C A M, Canté-Barrett, Kirsten, Stubbs, Andrew P, Vroegindeweij, Eric M, Smits, Willem K, van Marion, Ronald, Dinjens, Winand N M, Horstmann, Martin, Kuiper, Roland P, Buijsman, Rogier C, Zaman, Guido J R, van der Spek, Peter J, Pieters, Rob, Meijerink, Jules P P
Published in PLoS medicine (20.12.2016)
Published in PLoS medicine (20.12.2016)
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Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations
Antić, Željko, Yu, Jiangyan, Van Reijmersdal, Simon V, Van Dijk, Anke, Dekker, Linde, Segerink, Wouter H, Sonneveld, Edwin, Fiocco, Marta, Pieters, Rob, Hoogerbrugge, Peter M, Van Leeuwen, Frank N, Van Kessel, Ad Geurts, Waanders, Esme, Kuiper, Roland P
Published in Haematologica (Roma) (01.12.2021)
Published in Haematologica (Roma) (01.12.2021)
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Journal Article
Histone deacetylase inhibition sensitizes p53-deficient B-cell precursor acute lymphoblastic leukemia to chemotherapy
Cox, Willem P J, Evander, Nils, Van Ingen Schenau, Dorette S, Stoll, Gawin R, Anderson, Nadia, De Groot, Lieke, Grünewald, Kari J T, Hagelaar, Rico, Butler, Miriam, Kuiper, Roland P, Van der Meer, Laurens T, Van Leeuwen, Frank N
Published in Haematologica (Roma) (01.06.2024)
Published in Haematologica (Roma) (01.06.2024)
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Clinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome
Pastorczak, Agata, Szmyd, Bartosz, Braun, Marcin, Madzio, Joanna, Wypyszczak, Kamila, Sztromwasser, Pawel, Fendler, Wojciech, Wojtaszewska, Marzena, Chrzanowski, Jedrzej, Grajkowska, Wieslawa, Gregorek, Hanna, Wakulinska, Anna, Kazanowska, Bernarda, Krenova, Zdenka, Weijers, Dilys D, Kuiper, Roland P, Mlynarski, Wojciech
Published in Haematologica (Roma) (01.10.2023)
Published in Haematologica (Roma) (01.10.2023)
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Journal Article
Somatic reversion events point towards RPL4 as a novel disease gene in a condition resembling Diamond-Blackfan Anemia
Jongmans, Marjolijn C J, Diets, Illja J, Quarello, Paola, Garelli, Emanuela, Kuiper, Roland P, Pfundt, Rolph
Published in Haematologica (Roma) (01.12.2018)
Published in Haematologica (Roma) (01.12.2018)
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Journal Article
High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas
Yusenko, Maria V, Kuiper, Roland P, Boethe, Tamas, Ljungberg, Börje, van Kessel, Ad Geurts, Kovacs, Gyula
Published in BMC cancer (18.05.2009)
Published in BMC cancer (18.05.2009)
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Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade
Woess, Katharina, Macho-Maschler, Sabine, Van Ingen Schenau, Dorette S, Butler, Miriam, Lassnig, Caroline, Valcanover, Daniel, Poelzl, Andrea, Meissl, Katrin, Maurer, Barbara, Brandstoetter, Tania, Vogl, Claus, Koren, Anna, Kubicek, Stefan, Orlova, Anna, Moriggl, Richard, Strobl, Birgit, Sexl, Veronika, Van Leeuwen, Frank N, Kuiper, Roland P, Mueller, Mathias
Published in Haematologica (Roma) (01.04.2023)
Published in Haematologica (Roma) (01.04.2023)
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Journal Article
Revertant Somatic Mosaicism by Mitotic Recombination in Dyskeratosis Congenita
Jongmans, Marjolijn C.J., Verwiel, Eugene T.P., Heijdra, Yvonne, Vulliamy, Tom, Kamping, Eveline J., Hehir-Kwa, Jayne Y., Bongers, Ernie M.H.F., Pfundt, Rolph, van Emst, Liesbeth, van Leeuwen, Frank N., van Gassen, Koen L.I., Geurts van Kessel, Ad, Dokal, Inderjeet, Hoogerbrugge, Nicoline, Ligtenberg, Marjolijn J.L., Kuiper, Roland P.
Published in American journal of human genetics (09.03.2012)
Published in American journal of human genetics (09.03.2012)
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Journal Article
Deleterious Germline BLM Mutations and the Risk for Early-onset Colorectal Cancer
de Voer, Richarda M., Hahn, Marc-Manuel, Mensenkamp, Arjen R., Hoischen, Alexander, Gilissen, Christian, Henkes, Arjen, Spruijt, Liesbeth, van Zelst-Stams, Wendy A., Marleen Kets, C., Verwiel, Eugene T., Nagtegaal, Iris D., Schackert, Hans K., van Kessel, Ad Geurts, Hoogerbrugge, Nicoline, Ligtenberg, Marjolijn J.L., Kuiper, Roland P.
Published in Scientific reports (11.09.2015)
Published in Scientific reports (11.09.2015)
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The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution
Waanders, Esmé, Scheijen, Blanca, van der Meer, Laurens T, van Reijmersdal, Simon V, van Emst, Liesbeth, Kroeze, Yvet, Sonneveld, Edwin, Hoogerbrugge, Peter M, van Kessel, Ad Geurts, van Leeuwen, Frank N, Kuiper, Roland P
Published in PLoS genetics (01.02.2012)
Published in PLoS genetics (01.02.2012)
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Journal Article
Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility
de Voer, Richarda M, Hahn, Marc-Manuel, Weren, Robbert D A, Mensenkamp, Arjen R, Gilissen, Christian, van Zelst-Stams, Wendy A, Spruijt, Liesbeth, Kets, C Marleen, Zhang, Junxiao, Venselaar, Hanka, Vreede, Lilian, Schubert, Nil, Tychon, Marloes, Derks, Ronny, Schackert, Hans K, Geurts van Kessel, Ad, Hoogerbrugge, Nicoline, Ligtenberg, Marjolijn J L, Kuiper, Roland P
Published in PLoS genetics (22.02.2016)
Published in PLoS genetics (22.02.2016)
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