The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models
Lemos, Clara, Schulze, Volker K., Baumgart, Simon J., Nevedomskaya, Ekaterina, Heinrich, Tobias, Lefranc, Julien, Bader, Benjamin, Christ, Clara D., Briem, Hans, Kuhnke, Lara P., Holton, Simon J., Bömer, Ulf, Lienau, Philip, von Nussbaum, Franz, Nising, Carl F., Bauser, Marcus, Hägebarth, Andrea, Mumberg, Dominik, Haendler, Bernard
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Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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Published in Cell chemical biology (18.07.2024)
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Ahlberg, Ernst, Amberg, Alexander, Beilke, Lisa D., Bower, David, Cross, Kevin P., Custer, Laura, Ford, Kevin A., Van Gompel, Jacky, Harvey, James, Honma, Masamitsu, Jolly, Robert, Joossens, Elisabeth, Kemper, Raymond A., Kenyon, Michelle, Kruhlak, Naomi, Kuhnke, Lara, Leavitt, Penny, Naven, Russell, Neilan, Claire, Quigley, Donald P., Shuey, Dana, Spirkl, Hans-Peter, Stavitskaya, Lidiya, Teasdale, Andrew, White, Angela, Wichard, Joerg, Zwickl, Craig, Myatt, Glenn J.
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Abstract 4584: Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I and Rho-GTPase signaling
Graham, Keith, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Naujoks, Jan, Lesche, Ralf, Nicke, Barbara, Bone, Wilhelm, Golfier, Sven, Brzezinka, Krzysztof, Kaulfuss, Stefan, Kopitz, Charlotte, Steuber, Holger, Braeuer, Nico, Nowak-Reppel, Katrin, Stresemann, Carlo, Steigemann, Patrick, Kuehnlenz, Julia, Potze, Lisette, Zanconato, Francesca, Montebaur, Anna, Pilari, Sabine, Hayat, Sikander, Kamburov, Atanas, Steffen, Andreas, Schlicker, Andreas, Buchgraber, Philipp, Font, Nuria Aiguabella, Heinrich, Tobias, Kuhnke, Lara, Walter, Annette O., Blotta, Simona, Ocker, Matthias, Lakner, Ashley, Mumberg, Dominik, Eis, Knut, Piccolo, Stefano, Lange, Martin
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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MAP4K1 INHIBITORS
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Year of Publication 30.05.2024
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Year of Publication 30.05.2024
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MAP4K1 INHIBITORS
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Year of Publication 13.12.2023
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Year of Publication 13.12.2023
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MAP4K1 INHIBITORS
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Year of Publication 11.08.2022
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Year of Publication 11.08.2022
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Year of Publication 12.03.2020
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4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS
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4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS
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Year of Publication 12.03.2020
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Year of Publication 12.03.2020
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Year of Publication 12.03.2020
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COMPUESTOS DE 3,9-DIAZAESPIRO[5.5]UNDECANO COMO INHIBIDORES DE GGTasa I Y SU USO PARA EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS
LIENAU, PHILIP, KOPITZ, CHARLOTTE CHRISTINE, PRECHTL, STEFAN, POTZE, LISETTE, KIRK, RALPH STEVEN, BRUER, NICO, NOWAK-REPPEL, KATRIN, KUHNKE, LARA PATRICIA, WITTROCK, SVEN, LANGE, MARTIN, GRAHAM, KEITH, BADER, BENJAMIN, HEINRICH, TOBIAS, AIGUABELLA FONT, NURIA, BUCHGRABER, PHILIPP, STEUBER, HOLGER, HARVEY, REBECCA ANN
Year of Publication 25.03.2021
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Year of Publication 25.03.2021
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3,9-diazaspiro[5.5]undecane compounds
LIENAU, PHILIP, KOPITZ, CHARLOTTE CHRISTINE, PRECHTL, STEFAN, POTZE, LISETTE, KIRK, RALPH STEVEN, NOWAK-REPPEL, KATRIN, KUHNKE, LARA PATRICIA, WITTROCK, SVEN, GRAHAM, KEITH, LANGE, MARTIN, BADER, BENJAMIN, HEINRICH, TOBIAS, BUCHGRABER, PHILIPP, AIGUABELLA FONT, NURIA, BRAUER, NICO, STEUBER, HOLGER, HARVEY, REBECCA ANN
Year of Publication 01.07.2020
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Year of Publication 01.07.2020
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