Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides
Kasuya, Takeshi, Hori, Shin-ichiro, Watanabe, Ayahisa, Nakajima, Mado, Gahara, Yoshinari, Rokushima, Masatomo, Yanagimoto, Toru, Kugimiya, Akira
Published in Scientific reports (27.07.2016)
Published in Scientific reports (27.07.2016)
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RNA Reduction and Hepatotoxic Potential Caused by Non-Gapmer Antisense Oligonucleotides
Hori, Shin-Ichiro, Mitsuoka, Yasunori, Kugimiya, Akira
Published in Nucleic acid therapeutics (01.02.2019)
Published in Nucleic acid therapeutics (01.02.2019)
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S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes
Nakagawa, Takayuki, Tanino, Tetsuya, Onishi, Motoyasu, Tofukuji, Soichi, Kanazawa, Takayuki, Ishioka, Yukichi, Itoh, Takeshi, Kugimiya, Akira, Katayama, Kazufumi, Yamamoto, Takuya, Nagira, Morio, Ishii, Ken J
Published in Frontiers in immunology (23.12.2021)
Published in Frontiers in immunology (23.12.2021)
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Gene Silencing Activity and Hepatic Accumulation of Antisense Oligonucleotides Bearing Cholesterol-Conjugated Thiono Triester at the Gap Region
Nakajima, Mado, Kasuya, Takeshi, Yokota, Shinnichi, Onishi, Reina, Ikehara, Tatsuya, Kugimiya, Akira, Watanabe, Ayahisa
Published in Nucleic acid therapeutics (01.08.2017)
Published in Nucleic acid therapeutics (01.08.2017)
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Journal Article
Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency
Mitsuoka, Yasunori, Yamamoto, Tsuyoshi, Kugimiya, Akira, Waki, Reiko, Wada, Fumito, Tahara, Saori, Sawamura, Motoki, Noda, Mio, Fujimura, Yuko, Kato, Yuki, Hari, Yoshiyuki, Obika, Satoshi
Published in Journal of organic chemistry (06.01.2017)
Published in Journal of organic chemistry (06.01.2017)
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Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma
Takahashi, Go, Asanuma, Fujio, Suzuki, Noriko, Hattori, Maki, Sakamoto, Shingo, Kugimiya, Akira, Tomita, Yasuhiko, Kuwajima, Goro, Abraham, William M., Deguchi, Masashi, Arimura, Akinori, Shichijo, Michitaka
Published in European journal of pharmacology (15.10.2015)
Published in European journal of pharmacology (15.10.2015)
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Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure
Mitsuoka, Yasunori, Aoyama, Hiroshi, Kugimiya, Akira, Fujimura, Yuko, Yamamoto, Tsuyoshi, Waki, Reiko, Wada, Fumito, Tahara, Saori, Sawamura, Motoki, Noda, Mio, Hari, Yoshiyuki, Obika, Satoshi
Published in Organic & biomolecular chemistry (01.01.2016)
Published in Organic & biomolecular chemistry (01.01.2016)
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Surface Plasmon Resonance Assay of Binding Properties of Antisense Oligonucleotides to Serum Albumins and Lipoproteins
ONISHI, Reina, WATANABE, Ayahisa, NAKAJIMA, Mado, SEKIGUCHI, Mitsuaki, KUGIMIYA, Akira, KINOUCHI, Hiroki, NIHASHI, Yoichiro, KAMIMORI, Hiroshi
Published in Analytical Sciences (2015)
Published in Analytical Sciences (2015)
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Abstract 1916: Lymph node targeting double stranded CpG act effective adjuvant in cancer peptide vaccine
Nakagawa, Takayuki, Onishi, Motoyasu, Tofukuji, Soichi, Omoto, Shinya, Katayama, Kazufumi, Kugimiya, Akira, Nagira, Morio, Ishii, Ken J.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant
Kawada, Kenji, Arimura, Akinori, Tsuri, Tatsuo, Fuji, Masahiro, Komurasaki, Tadafumi, Yonezawa, Shuji, Kugimiya, Akira, Haga, Nobuhiro, Mitsumori, Susumu, Inagaki, Masanao, Nakatani, Takuji, Tamura, Yoshinori, Takechi, Shozo, Taishi, Teruhiko, Kishino, Junji, Ohtani, Mitsuaki
Published in Angewandte Chemie (International ed.) (20.04.1998)
Published in Angewandte Chemie (International ed.) (20.04.1998)
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Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands Targeting Apolipoprotein B
Watanabe, Ayahisa, Nakajima, Mado, Kasuya, Takeshi, Onishi, Reina, Kitade, Naohisa, Mayumi, Kei, Ikehara, Tatsuya, Kugimiya, Akira
Published in The Journal of pharmacology and experimental therapeutics (01.05.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2016)
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CATIONIC LIPID
TANINO Tetsuya, HAYATA Atsushi, KITAHATA Shun, KUGIMIYA Akira, NAKAMURA Jun, MORITA Ippei, KURODA Norikazu
Year of Publication 11.08.2022
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Year of Publication 11.08.2022
Patent
Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structureElectronic supplementary information (ESI) available. CCDC 1415387. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ob01051b
Mitsuoka, Yasunori, Aoyama, Hiroshi, Kugimiya, Akira, Fujimura, Yuko, Yamamoto, Tsuyoshi, Waki, Reiko, Wada, Fumito, Tahara, Saori, Sawamura, Motoki, Noda, Mio, Hari, Yoshiyuki, Obika, Satoshi
Year of Publication 06.07.2016
Year of Publication 06.07.2016
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Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins
Kamisuki, Shinji, Shirakawa, Takashi, Kugimiya, Akira, Abu-Elheiga, Lutfi, Park Choo, Hea-Young, Yamada, Kohei, Shimogawa, Hiroki, Wakil, Salih J, Uesugi, Motonari
Published in Journal of medicinal chemistry (14.07.2011)
Published in Journal of medicinal chemistry (14.07.2011)
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