In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives
Kudo, Kei, Hashimoto, Takuya, Hashimoto, Junko, Kozone, Ikuko, Kagaya, Noritaka, Ueoka, Reiko, Nishimura, Takehiro, Komatsu, Mamoru, Suenaga, Hikaru, Ikeda, Haruo, Shin-ya, Kazuo
Published in Nature communications (11.08.2020)
Published in Nature communications (11.08.2020)
Get full text
Journal Article
Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer
Kudo, Kei, Ozaki, Taro, Shin-ya, Kazuo, Nishiyama, Makoto, Kuzuyama, Tomohisa
Published in Journal of the American Chemical Society (24.05.2017)
Published in Journal of the American Chemical Society (24.05.2017)
Get full text
Journal Article
Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster
Nishimura, Takehiro, Kudo, Kei, Izumikawa, Miho, Kozone, Ikuko, Hashimoto, Junko, Kagaya, Noritaka, Suenaga, Hikaru, Takeuchi, Koh, Shin-ya, Kazuo
Published in Chemical & pharmaceutical bulletin (16.05.2024)
Published in Chemical & pharmaceutical bulletin (16.05.2024)
Get full text
Journal Article
Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase
Kudo, Kei, Nishimura, Takehiro, Kozone, Ikuko, Hashimoto, Junko, Kagaya, Noritaka, Suenaga, Hikaru, Ikeda, Haruo, Shin-ya, Kazuo
Published in Scientific reports (11.05.2021)
Published in Scientific reports (11.05.2021)
Get full text
Journal Article
An Atypical Arginine Dihydrolase Involved in the Biosynthesis of Cyclic Hexapeptide Longicatenamides
Liu, Chao, Hashimoto, Junko, Kudo, Kei, Shin‐ya, Kazuo, Kakeya, Hideaki
Published in Chemistry, an Asian journal (01.06.2021)
Published in Chemistry, an Asian journal (01.06.2021)
Get full text
Journal Article
Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds
Kudo, Kei, Nishimura, Takehiro, Izumikawa, Miho, Kozone, Ikuko, Hashimoto, Junko, Fujie, Manabu, Suenaga, Hikaru, Ikeda, Haruo, Satoh, Nori, Shin-ya, Kazuo
Published in Journal of antibiotics (01.05.2024)
Published in Journal of antibiotics (01.05.2024)
Get full text
Journal Article
Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma
Nomura, Miyuki, Ohuchi, Mai, Sakamoto, Yoshimi, Kudo, Kei, Yaku, Keisuke, Soga, Tomoyoshi, Sugiura, Yuki, Morita, Mami, Hayashi, Kayoko, Miyahara, Shuko, Sato, Taku, Yamashita, Yoji, Ito, Shigemi, Kikuchi, Naohiko, Sato, Ikuro, Saito, Rintaro, Yaegashi, Nobuo, Fukuhara, Tatsuro, Yamada, Hidekazu, Shima, Hiroshi, Nakayama, Keiichi I., Hirao, Atsushi, Kawasaki, Kenta, Arai, Yoichi, Akamatsu, Shusuke, Tanuma, Sei-ichi, Sato, Toshiro, Nakagawa, Takashi, Tanuma, Nobuhiro
Published in Nature communications (13.12.2023)
Published in Nature communications (13.12.2023)
Get full text
Journal Article
Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancer
Kudo, Kei, Nomura, Miyuki, Sakamoto, Yoshimi, Ito, Shigemi, Morita, Mami, Kawai, Masaaki, Yamashita, Yoji, Ito, Kiyoshi, Yamada, Hidekazu, Shima, Hiroshi, Yaegashi, Nobuo, Tanuma, Nobuhiro
Published in FEBS letters (01.05.2020)
Published in FEBS letters (01.05.2020)
Get full text
Journal Article
A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900
Ueoka, Reiko, Hashimoto, Junko, Kozone, Ikuko, Hashimoto, Takuya, Kudo, Kei, Kagaya, Noritaka, Suenaga, Hikaru, Ikeda, Haruo, Shin-ya, Kazuo
Published in Bioscience, biotechnology, and biochemistry (24.03.2021)
Published in Bioscience, biotechnology, and biochemistry (24.03.2021)
Get full text
Journal Article
Comprehensive Derivatization of Thioviridamides by Heterologous Expression
Kudo, Kei, Koiwai, Hanae, Kagaya, Noritaka, Nishiyama, Makoto, Kuzuyama, Tomohisa, Shin-ya, Kazuo, Ikeda, Haruo
Published in ACS chemical biology (21.06.2019)
Published in ACS chemical biology (21.06.2019)
Get full text
Journal Article
Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer
Hishinuma, Eiji, Shimada, Muneaki, Matsukawa, Naomi, Saigusa, Daisuke, Li, Bin, Kudo, Kei, Tsuji, Keita, Shigeta, Shogo, Tokunaga, Hideki, Kumada, Kazuki, Komine, Keigo, Shirota, Hidekazu, Aoki, Yuichi, Motoike, Ikuko N, Yasuda, Jun, Kinoshita, Kengo, Yamamoto, Masayuki, Koshiba, Seizo, Yaegashi, Nobuo
Published in Toxins (30.06.2021)
Published in Toxins (30.06.2021)
Get full text
Journal Article
New azodyrecins identified by a genome mining-directed reactivity-based screening
Choirunnisa, Atina Rizkiya, Arima, Kuga, Abe, Yo, Kagaya, Noritaka, Kudo, Kei, Suenaga, Hikaru, Hashimoto, Junko, Fujie, Manabu, Satoh, Noriyuki, Shin-ya, Kazuo, Matsuda, Kenichi, Wakimoto, Toshiyuki
Published in Beilstein journal of organic chemistry (10.08.2022)
Published in Beilstein journal of organic chemistry (10.08.2022)
Get full text
Journal Article
Endoscopic examination of labial fusion in a postmenopausal woman: a case report
Kumagai, Yusaku, Toyoshima, Masafumi, Kudo, Kei, Ohsawa, Minoru, Niikura, Hitoshi, Yaegashi, Nobuo
Published in Journal of medical case reports (02.02.2018)
Published in Journal of medical case reports (02.02.2018)
Get full text
Journal Article
Factors related to feelings of burden among caregivers looking after impaired elderly in Japan under the Long‐Term Care insurance system
ARAI, YUMIKO, KUMAMOTO, KEIGO, WASHIO, MASAKAZU, UEDA, TERUKO, MIURA, HIROKO, KUDO, KEI
Published in Psychiatry and clinical neurosciences (01.08.2004)
Published in Psychiatry and clinical neurosciences (01.08.2004)
Get full text
Journal Article
Reliability and validity of the Japanese version of the Zarit Caregiver Burden Interview
ARAI, YUMIKO, MD, KEI KUDO, HOSOKAWA, TORU, WASHIO, MASAKAZU, MIURA, HIROKO, HISAMICHI, SHIGERU
Published in Psychiatry and clinical neurosciences (01.10.1997)
Published in Psychiatry and clinical neurosciences (01.10.1997)
Get full text
Journal Article
Conference Proceeding
Caregiver depression predicts early discontinuation of care for disabled elderly at home
Arai, Yumiko, Sugiura, Midori, Washio, Masakazu, Miura, Hiroko, Kudo, Kei
Published in Psychiatry and clinical neurosciences (01.08.2001)
Published in Psychiatry and clinical neurosciences (01.08.2001)
Get full text
Journal Article