CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models
Drake, Penelope M, Carlson, Adam, McFarland, Jesse M, Bañas, Stefanie, Barfield, Robyn M, Zmolek, Wesley, Kim, Yun Cheol, Huang, Betty C B, Kudirka, Romas, Rabuka, David
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Site-Specific Tandem Knoevenagel Condensation–Michael Addition To Generate Antibody–Drug Conjugates
Kudirka, Romas A, Barfield, Robyn M, McFarland, Jesse M, Drake, Penelope M, Carlson, Adam, Bañas, Stefanie, Zmolek, Wes, Garofalo, Albert W, Rabuka, David
Published in ACS medicinal chemistry letters (10.11.2016)
Published in ACS medicinal chemistry letters (10.11.2016)
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Journal Article
1147-D Preclinical characterization of a novel claudin 18.2 targeting-ISAC with robust potency and acceptable safety profile
Kim, Han K, Monnier, Justin, Fu, Chi-Ling, Zhou, Matthew, Melrose, Jennifer E, Dao, Hung, Ponath, Paul D, McEachin, Katelynn A, Omstead, David T, Kreder, Cindy, Chun, Stefan, Lee, Ying Yueh, Grgich, Rachel, Lin, Tracey J, Walker, Joshua A, Henning, Karla A, Kudirka, Romas, Ackerman, Shelley E, Carrera, Diane, Chapin, Steven J, Mallet, William, Jackson, Dowdy, Gao, Changshou, Alonso, Michael N
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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784 BDC-2034: discovery of a CEA-targeting immune-stimulating antibody conjugate (ISAC) for solid tumors
Mallet, William, Gadkari, Rishali, Pearson, Cecelia, Torrez Dulgeroff, Laughing Bear, Luo, Angela, Luo, AAngela Luondrew, Melrose, Jennifer, Nolin, Jess, Lee, Arthur, Zhou, Matthew, Anand, Puneet, Sarma, Ganapathy, Henning, Karla, Blum, Lisa, Chapin, Steven, Bogaert, Liz, Ackerman, Shelley, Kudirka, Romas, Shen, Yuyi, Husain, Amreen, Perez, Edith, Kowanetz, Marcin, Alonso, Michael, Safina, Brian, Dornan, David
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes
Drake, Penelope M, Albers, Aaron E, Baker, Jeanne, Banas, Stefanie, Barfield, Robyn M, Bhat, Abhijit S, de Hart, Gregory W, Garofalo, Albert W, Holder, Patrick, Jones, Lesley C, Kudirka, Romas, McFarland, Jesse, Zmolek, Wes, Rabuka, David
Published in Bioconjugate chemistry (16.07.2014)
Published in Bioconjugate chemistry (16.07.2014)
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Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates
Agarwal, Paresh, Kudirka, Romas, Albers, Aaron E, Barfield, Robyn M, de Hart, Gregory W, Drake, Penelope M, Jones, Lesley C, Rabuka, David
Published in Bioconjugate chemistry (19.06.2013)
Published in Bioconjugate chemistry (19.06.2013)
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Journal Article
Shaken, Not Stirred: Collapsing a Peptoid Monolayer To Produce Free-Floating, Stable Nanosheets
Sanii, Babak, Kudirka, Romas, Cho, Andrew, Venkateswaran, Neeraja, Olivier, Gloria K, Olson, Alexander M, Tran, Helen, Harada, R. Marika, Tan, Li, Zuckermann, Ronald N
Published in Journal of the American Chemical Society (28.12.2011)
Published in Journal of the American Chemical Society (28.12.2011)
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항체-접합된 8-설포닐-벤자제핀 화합물 및 이의 용도
SAFINA BRIAN, ALONSO MICHAEL N, ACKERMAN SHELLEY ERIN, KUDIRKA ROMAS, SARMA GANAPATHY
Year of Publication 20.09.2024
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Year of Publication 20.09.2024
Patent
Exploring the effects of linker composition on site-specifically modified antibody–drug conjugates
Albers, Aaron E., Garofalo, Albert W., Drake, Penelope M., Kudirka, Romas, de Hart, Gregory W., Barfield, Robyn M., Baker, Jeanne, Banas, Stefanie, Rabuka, David
Published in European journal of medicinal chemistry (17.12.2014)
Published in European journal of medicinal chemistry (17.12.2014)
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Journal Article
Folding of a single-chain, information-rich polypeptoid sequence into a highly ordered nanosheet
Kudirka, Romas, Tran, Helen, Sanii, Babak, Nam, Ki Tae, Choi, Philip H., Venkateswaran, Neeraja, Chen, Ritchie, Whitelam, Stephen, Zuckermann, Ronald N.
Published in Biopolymers (2011)
Published in Biopolymers (2011)
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암 치료에 유용한 하나 이상의 8-HET-2-아미노벤자제핀유도체에 대한 접합에 의해 연결된 항-CEA 항체를 포함하는 면역접합체
SAFINA BRIAN, LEE ARTHUR, ALONSO MICHAEL N, ACKERMAN SHELLEY ERIN, KOWANETZ MARCIN, MALLET WILLIAM, KUDIRKA ROMAS, DORNAN DAVID, ZHOU MATTHEW
Year of Publication 10.08.2023
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Year of Publication 10.08.2023
Patent