Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury
Koga, Keisuke, Kobayashi, Kenta, Tsuda, Makoto, Kubota, Kazufumi, Kitano, Yutaka, Furue, Hidemasa
Published in Frontiers in molecular neuroscience (23.03.2023)
Published in Frontiers in molecular neuroscience (23.03.2023)
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Infantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese Families
Okuda, Hiroko, Noguchi, Atsuko, Kobayashi, Hatasu, Kondo, Daiki, Harada, Kouji H, Youssefian, Shohab, Shioi, Hirotomo, Kabata, Risako, Domon, Yuki, Kubota, Kazufumi, Kitano, Yutaka, Takayama, Yasunori, Hitomi, Toshiaki, Ohno, Kousaku, Saito, Yoshiaki, Asano, Takeshi, Tominaga, Makoto, Takahashi, Tsutomu, Koizumi, Akio
Published in PloS one (25.05.2016)
Published in PloS one (25.05.2016)
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Discovery of a Novel Class of State-Dependent NaV1.7 Inhibitors for the Treatment of Neuropathic Pain
Tanaka, Kyosuke, Kobayashi, Hiroyuki, Suzuki, Sayaka, Shibuya, Satoshi, Kimoto, Hiroko, Domon, Yuki, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Shinozuka, Tsuyoshi
Published in Chemical & pharmaceutical bulletin (01.07.2020)
Published in Chemical & pharmaceutical bulletin (01.07.2020)
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Discovery of a Novel Class of State-Dependent Na(V)1.7 Inhibitors for the Treatment of Neuropathic Pain
Tanaka, Kyosuke, Kobayashi, Hiroyuki, Suzuki, Sayaka, Shibuya, Satoshi, Kimoto, Hiroko, Domon, Yuki, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Shinozuka, Tsuyoshi
Published in Chemical & pharmaceutical bulletin (01.07.2020)
Published in Chemical & pharmaceutical bulletin (01.07.2020)
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Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain
Ghilardi, Joseph R, Rohrich, Heidi, Lindsay, Theodore H, Sevcik, Molly A, Schwei, Matthew J, Kubota, Kazufumi, Halvorson, Kyle G, Poblete, Jeannie, Chaplan, Sandra R, Dubin, Adrienne E, Carruthers, Nicholas I, Swanson, Devin, Kuskowski, Michael, Flores, Christopher M, Julius, David, Mantyh, Patrick W
Published in The Journal of neuroscience (23.03.2005)
Published in The Journal of neuroscience (23.03.2005)
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Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models
Shimada, Kohei, Tengeiji, Atsushi, Kiho, Toshihiro, Sugimoto, Kotaro, Kubota, Kazufumi, Kuwabara, Harumi, Sugita, Ryusuke, Kawakami, Katsuhiro
Published in Mediators of inflammation (2016)
Published in Mediators of inflammation (2016)
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Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization
Sevcik, Molly A., Ghilardi, Joseph R., Peters, Christopher M., Lindsay, Theodore H., Halvorson, Kyle G., Jonas, Beth M., Kubota, Kazufumi, Kuskowski, Michael A., Boustany, Leila, Shelton, David L., Mantyh, Patrick W.
Published in Pain (Amsterdam) (01.05.2005)
Published in Pain (Amsterdam) (01.05.2005)
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A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone
HALVORSON, Kyle G, KUBOTA, Kazufumi, SEVCIK, Molly A, LINDSAY, Theodore H, SOTILLO, Julio E, GHILARDI, Joseph R, ROSOL, Thomas J, BOUSTANY, Leila, SHELTON, David L, MANTYH, Patrick W
Published in Cancer research (Chicago, Ill.) (15.10.2005)
Published in Cancer research (Chicago, Ill.) (15.10.2005)
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A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models
Sugita, Ryusuke, Kubota, Kazufumi, Sugimoto, Kotaro, Tachida, Yuki, Shibayama, Takahiro, Kiho, Toshihiro, Kawakami, Katsuhiro, Shimada, Kohei
Published in Journal of pharmacological sciences (01.02.2016)
Published in Journal of pharmacological sciences (01.02.2016)
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A Novel Selective Prostaglandin E2 Synthesis Inhibitor Relieves Pyrexia and Chronic Inflammation in Rats
Sugita, Ryusuke, Kuwabara, Harumi, Sugimoto, Kotaro, Kubota, Kazufumi, Imamura, Yuichiro, Kiho, Toshihiro, Tengeiji, Atsushi, Kawakami, Katsuhiro, Shimada, Kohei
Published in Inflammation (01.04.2016)
Published in Inflammation (01.04.2016)
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Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain
Peters, Christopher M., Ghilardi, Joseph R., Keyser, Cathy P., Kubota, Kazufumi, Lindsay, Theodore H., Luger, Nancy M., Mach, David B., Schwei, Matthew J., Sevcik, Molly A., Mantyh, Patrick W.
Published in Experimental neurology (01.05.2005)
Published in Experimental neurology (01.05.2005)
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Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors
Suzuki, Sayaka, Kuroda, Takeshi, Kimoto, Hiroko, Domon, Yuki, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Shimizugawa, Akiko, Sugita, Ryusuke, Koishi, Ryuta, Asano, Daigo, Tamaki, Kazuhiko, Shinozuka, Tsuyoshi, Kobayashi, Hiroyuki
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model
Sevcik, Molly A, Ghilardi, Joseph R, Halvorson, Kyle G, Lindsay, Theodore H, Kubota, Kazufumi, Mantyh, Patrick W
Published in The journal of pain (01.11.2005)
Published in The journal of pain (01.11.2005)
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The Novel Gabapentinoid Mirogabalin Prevents Upregulation of α2δ-1 Subunit of Voltage-Gated Calcium Channels in Spinal Dorsal Horn in a Rat Model of Spinal Nerve Ligation
Domon, Yuki, Kobayashi, Naoko, Kubota, Kazufumi, Kitano, Yutaka, Ueki, Hideaki, Shimojo, Yumiko, Ishikawa, Kayoko, Ofune, Yuka
Published in Drug research (01.01.2023)
Published in Drug research (01.01.2023)
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Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity
Arita, Tsuyoshi, Asano, Masayoshi, Kubota, Kazufumi, Domon, Yuki, Machinaga, Nobuo, Shimada, Kousei
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
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Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity
Arita, Tsuyoshi, Asano, Masayoshi, Kubota, Kazufumi, Domon, Yuki, Machinaga, Nobuo, Shimada, Kousei
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
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Journal Article
Voltage-gated calcium channel subunit α 2 δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury
Koga, Keisuke, Kobayashi, Kenta, Tsuda, Makoto, Kubota, Kazufumi, Kitano, Yutaka, Furue, Hidemasa
Published in Frontiers in molecular neuroscience (2023)
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Published in Frontiers in molecular neuroscience (2023)
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Anxiolytic-like effects of mirogabalin, a novel ligand for α2δ ligand of voltage-gated calcium channels, in rats repeatedly injected with acidic saline intramuscularly, as an experimental model of fibromyalgia
Murasawa, Hiroyasu, Kobayashi, Hiroyuki, Yasuda, Shun-ichi, Saeki, Kensuke, Domon, Yuki, Arakawa, Naohisa, Kubota, Kazufumi, Kitano, Yutaka
Published in Pharmacological reports (01.06.2020)
Published in Pharmacological reports (01.06.2020)
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A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity
Noguchi, Tetsuji, Umezaki, Yuma, Takano, Rieko, Fujimoto, Teppei, Domon, Yuki, Kubota, Kazufumi, Ueda, Kenjiro, Kawase, Yumi, Yabe, Koichi, Yokoyama, Miki, Shimada, Kousei
Published in Bioorganic & medicinal chemistry letters (15.03.2021)
Published in Bioorganic & medicinal chemistry letters (15.03.2021)
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