Workflow Comparison for Label-Free, Quantitative Secretome Proteomics for Cancer Biomarker Discovery: Method Evaluation, Differential Analysis, and Verification in Serum
Piersma, Sander R, Fiedler, Ulrike, Span, Simone, Lingnau, Andreas, Pham, Thang V, Hoffmann, Steffen, Kubbutat, Michael H. G, Jiménez, Connie R
Published in Journal of proteome research (05.04.2010)
Published in Journal of proteome research (05.04.2010)
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Cytotoxic effects of the anthraquinone derivatives 1′-deoxyrhodoptilometrin and (S)-(−)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp
Wätjen, Wim, Ebada, Sherif S., Bergermann, Anja, Chovolou, Yvonni, Totzke, Frank, Kubbutat, Michael H. G., Lin, Wenhan, Proksch, Peter
Published in Archives of toxicology (01.03.2017)
Published in Archives of toxicology (01.03.2017)
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Arthrinins A–D: Novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp
Ebada, Sherif S., Schulz, Barbara, Wray, Victor, Totzke, Frank, Kubbutat, Michael H.G., Müller, Werner E.G., Hamacher, Alexandra, Kassack, Matthias U., Lin, Wenhan, Proksch, Peter
Published in Bioorganic & medicinal chemistry (01.08.2011)
Published in Bioorganic & medicinal chemistry (01.08.2011)
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Meriolins, a new class of cell death -Inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases
BETTAYEB, Karima, TIRADE, Oscar M, LIGER, Francois, MARQUET, Bernard, JOSEPH, Benoit, ECHALIER, Aude, ENDICOTT, Jane A, NOTARIO, Vicente, MEIJER, Laurent, MARIONNEAU-LAMBOT, Séverine, FERANDIN, Yoan, LOZACH, Olivier, MORRIS, Jonathan C, MATEO-LOZANO, Silvia, DRUECKES, Peter, SCHÄCHTELE, Christoph, KUBBUTAT, Michael H. G
Published in Cancer research (Chicago, Ill.) (01.09.2007)
Published in Cancer research (Chicago, Ill.) (01.09.2007)
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Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa
Shi, Cui, Xu, Min-Juan, Bayer, Mirko, Deng, Zhi-Wei, Kubbutat, Michael H.G., Waejen, Wim, Proksch, Peter, Lin, Wen-Han
Published in Phytochemistry (Oxford) (01.03.2010)
Published in Phytochemistry (Oxford) (01.03.2010)
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Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization
Tasler, Stefan, Müller, Oliver, Wieber, Tanja, Herz, Thomas, Pegoraro, Stefano, Saeb, Wael, Lang, Martin, Krauss, Rolf, Totzke, Frank, Zirrgiebel, Ute, Ehlert, Jan E., Kubbutat, Michael H.G., Schächtele, Christoph
Published in Bioorganic & medicinal chemistry (15.09.2009)
Published in Bioorganic & medicinal chemistry (15.09.2009)
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7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors
Karatas, Mehmet, Chaikuad, Apirat, Berger, Bianca, Kubbutat, Michael H G, Totzke, Frank, Knapp, Stefan, Kunick, Conrad
Published in Molecules (Basel, Switzerland) (14.03.2021)
Published in Molecules (Basel, Switzerland) (14.03.2021)
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Identification of a cryptic nucleolar-localization signal in MDM2
Vousden, Karen H, Lohrum, Marion A. E, Ashcroft, Margaret, Kubbutat, Michael H. G
Published in Nature cell biology (01.03.2000)
Published in Nature cell biology (01.03.2000)
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Journal Article
Cytotoxic Metabolites from the Fungal Endophyte Alternaria sp. and Their Subsequent Detection in Its Host Plant Polygonum senegalense
Aly, Amal H, Edrada-Ebel, RuAngelie, Indriani, Ine Dewi, Wray, Victor, Müller, Werner E. G, Totzke, Frank, Zirrgiebel, Ute, Schächtele, Christoph, Kubbutat, Michael H. G, Lin, W. H, Proksch, Peter, Ebel, Rainer
Published in Journal of natural products (Washington, D.C.) (01.06.2008)
Published in Journal of natural products (Washington, D.C.) (01.06.2008)
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Journal Article
Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases
Thaher, Bassam Abu, Arnsmann, Martina, Totzke, Frank, Ehlert, Jan E, Kubbutat, Michael H. G, Schächtele, Christoph, Zimmermann, Markus O, Koch, Pierre, Boeckler, Frank M, Laufer, Stefan A
Published in Journal of medicinal chemistry (26.01.2012)
Published in Journal of medicinal chemistry (26.01.2012)
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Targeting hormone refractory prostate cancer by in vivo selected DNA libraries in an orthotopic xenograft mouse model
Civit, Laia, Theodorou, Ioanna, Frey, Franziska, Weber, Holger, Lingnau, Andreas, Gröber, Carsten, Blank, Michael, Dambrune, Chloé, Stunden, James, Beyer, Marc, Schultze, Joachim, Latz, Eicke, Ducongé, Frédéric, Kubbutat, Michael H. G., Mayer, Günter
Published in Scientific reports (21.03.2019)
Published in Scientific reports (21.03.2019)
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Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum Isolated from Mentha pulegium
Debbab, Abdessamad, Aly, Amal H, Edrada-Ebel, RuAngelie, Wray, Victor, Müller, Werner E. G, Totzke, Frank, Zirrgiebel, Ute, Schächtele, Christoph, Kubbutat, Michael H. G, Lin, Wen Han, Mosaddak, Mahjouba, Hakiki, Abdelhak, Proksch, Peter, Ebel, Rainer
Published in Journal of natural products (Washington, D.C.) (24.04.2009)
Published in Journal of natural products (Washington, D.C.) (24.04.2009)
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2-Anilino-4-(benzimidazol-2-yl)pyrimidines – A multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines
Determann, Renate, Dreher, Jan, Baumann, Knut, Preu, Lutz, Jones, Peter G., Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael H.G., Kunick, Conrad
Published in European journal of medicinal chemistry (01.07.2012)
Published in European journal of medicinal chemistry (01.07.2012)
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Journal Article
Identification of 2-Anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as Dual PLK1/VEGF-R2 Kinase Inhibitor Chemotypes by Structure-Based Lead Generation
Egert-Schmidt, Anne-Marie, Dreher, Jan, Dunkel, Ute, Kohfeld, Simone, Preu, Lutz, Weber, Holger, Ehlert, Jan E, Mutschler, Bettina, Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael H. G, Baumann, Knut, Kunick, Conrad
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Assessing the Target Differentiation Potential of Imidazole-Based Protein Kinase Inhibitors
Dimova, Dilyana, Iyer, Preeti, Vogt, Martin, Totzke, Frank, Kubbutat, Michael H. G, Schächtele, Christoph, Laufer, Stefan, Bajorath, Jürgen
Published in Journal of medicinal chemistry (27.12.2012)
Published in Journal of medicinal chemistry (27.12.2012)
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Journal Article
Regulation of p53 stability by Mdm2
Kubbutat, Michael H. G, Jones, Stephen N, Vousden, Karen H
Published in Nature (London) (15.05.1997)
Published in Nature (London) (15.05.1997)
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Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1 H-indol-3-yl)-2-oxoacetohydrazide structure
Schmidt, Stefanie, Preu, Lutz, Lemcke, Thomas, Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael H.G., Kunick, Conrad
Published in European journal of medicinal chemistry (01.07.2011)
Published in European journal of medicinal chemistry (01.07.2011)
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A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries
Oehmig, Angelika, Klotzbücher, Andrea, Thomas, Maria, Weise, Frank, Hagner, Ursula, Brundiers, Ralf, Waldherr, Dirk, Lingnau, Andreas, Knappik, Achim, Kubbutat, Michael H G, Joos, Thomas O, Volkmer, Hansjürgen
Published in BMC genomics (24.09.2008)
Published in BMC genomics (24.09.2008)
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Search for Inhibitors of Bacterial and Human Protein Kinases among Derivatives of Diazepines[1,4] Annelated with Maleimide and Indole Cycles
Danilenko, Valery N, Simonov, Alexander Y, Lakatosh, Sergey A, Kubbutat, Michael H. G, Totzke, Frank, Schächtele, Christoph, Elizarov, Sergey M, Bekker, Olga B, Printsevskaya, Svetlana S, Luzikov, Yuryi N, Reznikova, Marina I, Shtil, Alexander A, Preobrazhenskaya, Maria N
Published in Journal of medicinal chemistry (25.12.2008)
Published in Journal of medicinal chemistry (25.12.2008)
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Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors
Barbosa, Maria Letícia de Castro, Lima, Lídia Moreira, Tesch, Roberta, Sant'Anna, Carlos Mauricio R., Totzke, Frank, Kubbutat, Michael H.G., Schächtele, Christoph, Laufer, Stefan A., Barreiro, Eliezer J.
Published in European journal of medicinal chemistry (01.01.2014)
Published in European journal of medicinal chemistry (01.01.2014)
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