Inactivation of Caspase‐1 in Rodent Brain: A Novel Anticonvulsive Strategy
Ravizza, Teresa, Lucas, Sian‐Marie, Balosso, Silvia, Bernardino, Liliana, Ku, George, Noé, Francesco, Malva, Joao, Randle, John C. R., Allan, Stuart, Vezzani, Annamaria
Published in Epilepsia (Copenhagen) (01.07.2006)
Published in Epilepsia (Copenhagen) (01.07.2006)
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Journal Article
RelB Modulation of IκBα Stability as a Mechanism of Transcription Suppression of Interleukin-1α (IL-1α), IL-1β, and Tumor Necrosis Factor Alpha in Fibroblasts
Xia, Yiyang, Chen, Shizhong, Wang, Yibin, Mackman, Nigel, Ku, George, Lo, David, Feng, Lili
Published in Molecular and Cellular Biology (01.11.1999)
Published in Molecular and Cellular Biology (01.11.1999)
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Journal Article
( S )-1-(( S )-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2 R ,3 S )-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18
Wannamaker, Woods, Davies, Robert, Namchuk, Mark, Pollard, John, Ford, Pamella, Ku, George, Decker, Caroline, Charifson, Paul, Weber, Peter, Germann, Ursula A., Kuida, Keisuke, Randle, John C. R.
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
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Journal Article
Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X₇ receptor-mediated IL-1β release
Bernardino, Liliana, Balosso, Silvia, Ravizza, Teresa, Marchi, Nicola, Ku, George, Randle, John C, Malva, João O, Vezzani, Annamaria
Published in Journal of neurochemistry (01.07.2008)
Published in Journal of neurochemistry (01.07.2008)
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Journal Article
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
Gu, Yong, Kuida, Keisuke, Tsutsui, Hiroko, Ku, George, Hsiao, Kathy, Fleming, Mark A., Hayashi, Nobuki, Higashino, Kazuya, Okamura, Haruki, Nakanishi, Kenji, Kurimoto, Masashi, Tanimoto, Tadao, Flavell, Richard A., Sato, Vicki, Harding, Matthew W., Livingston, David J., Michael S.-S. Su
Published in Science (American Association for the Advancement of Science) (10.01.1997)
Published in Science (American Association for the Advancement of Science) (10.01.1997)
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Journal Article
Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
Kuida, Keisuke, Lippke, Judith A., Ku, George, Harding, Matthew W., Livingston, David J., Michael S.-S. Su, Flavell, Richard A.
Published in Science (American Association for the Advancement of Science) (31.03.1995)
Published in Science (American Association for the Advancement of Science) (31.03.1995)
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Journal Article
Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7 receptor-mediated IL-1[beta] release
Bernardino, Liliana, Balosso, Silvia, Ravizza, Teresa, Marchi, Nicola, Ku, George, Randle, John C, Malva, João O, Vezzani, Annamaria
Published in Journal of neurochemistry (01.07.2008)
Published in Journal of neurochemistry (01.07.2008)
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Journal Article
Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X 7 receptor‐mediated IL‐1β release
Bernardino, Liliana, Balosso, Silvia, Ravizza, Teresa, Marchi, Nicola, Ku, George, Randle, John C., Malva, João O., Vezzani, Annamaria
Published in Journal of neurochemistry (01.07.2008)
Published in Journal of neurochemistry (01.07.2008)
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Journal Article
Response to local inflammation of IL-1 beta-converting enzyme- deficient mice
Fantuzzi, G, Ku, G, Harding, MW, Livingston, DJ, Sipe, JD, Kuida, K, Flavell, RA, Dinarello, CA
Published in The Journal of immunology (1950) (15.02.1997)
Published in The Journal of immunology (1950) (15.02.1997)
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Journal Article
Coadministration of interleukin-18 and interleukin-12 induces a fatal inflammatory response in mice: critical role of natural killer cell interferon-γ production and STAT-mediated signal transduction
Carson, William E., Dierksheide, Julie E., Jabbour, Saad, Anghelina, Mirela, Bouchard, Page, Ku, George, Yu, Haixin, Baumann, Heinz, Shah, Manisha H., Cooper, Megan A., Durbin, Joan, Caligiuri, Michael A.
Published in Blood (15.08.2000)
Published in Blood (15.08.2000)
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Journal Article
ICE/Caspase-1 inhibitors as novel anti-inflammatory drugs
Randle, J C, Harding, M W, Ku, G, Schönharting, M, Kurrle, R
Published in Expert opinion on investigational drugs (01.07.2001)
Published in Expert opinion on investigational drugs (01.07.2001)
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Journal Article
(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18
Woods Wannamaker, Robert Davies, Mark Namchuk, John Pollard, Pamella Ford, George Ku, Caroline Decker, Paul Charifson, Peter Weber, Ursula A. Germann, Keisuke Kuida, John C. R. Randle
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
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Journal Article
A Fatal Cytokine-Induced Systemic Inflammatory Response Reveals a Critical Role for NK Cells
Carson, William E, Yu, Haixin, Dierksheide, Julie, Pfeffer, Klaus, Bouchard, Page, Clark, Reed, Durbin, Joan, Baldwin, Albert S, Peschon, Jacques, Johnson, Philip R, Ku, George, Baumann, Heinz, Caligiuri, Michael A
Published in The Journal of immunology (1950) (15.04.1999)
Published in The Journal of immunology (1950) (15.04.1999)
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Journal Article
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18
Wannamaker, Woods, Davies, Robert, Namchuk, Mark, Pollard, John, Ford, Pamella, Ku, George, Decker, Caroline, Charifson, Paul, Weber, Peter, Germann, Ursula A, Kuida, Keisuke, Randle, John C R
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
Journal Article
IL-18 translational inhibition restricts IFN- expression in crescentic glomerulonephritis
Garcia, Gabriela E, Xia, Yiyang, Ku, George, Johnson, Richard J, Wilson, Curtis B, Feng, Lili
Published in Kidney international (01.07.2003)
Published in Kidney international (01.07.2003)
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Journal Article
IL-18 translational inhibition restricts IFN-γ expression in crescentic glomerulonephritis
Garcia, Gabriela E., Xia, Yiyang, Ku, George, Johnson, Richard J., Wilson, Curtis B., Feng, Lili
Published in Kidney international (01.07.2003)
Published in Kidney international (01.07.2003)
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Journal Article
A novel ultrasound imaging mobile connectivity app
Ku, George, Livingston, Jared, Blankenburg, Jeffrey
Published in 2014 4th International Conference on Wireless Mobile Communication and Healthcare - Transforming Healthcare Through Innovations in Mobile and Wireless Technologies (MOBIHEALTH) (01.11.2014)
Published in 2014 4th International Conference on Wireless Mobile Communication and Healthcare - Transforming Healthcare Through Innovations in Mobile and Wireless Technologies (MOBIHEALTH) (01.11.2014)
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