Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors
den Boon, Femke S, Chameau, Pascal, Schaafsma-Zhao, Qiluan, van Aken, Willem, Bari, Monica, Oddi, Sergio, Kruse, Chris G, Maccarrone, Mauro, Wadman, Wytse J, Werkman, Taco R
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2012)
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Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease
Bossers, Koen, Wirz, Kerstin T.S., Meerhoff, Gideon F., Essing, Anke H.W., van Dongen, Jeroen W., Houba, Pieter, Kruse, Chris G., Verhaagen, Joost, Swaab, Dick F.
Published in Brain (London, England : 1878) (01.12.2010)
Published in Brain (London, England : 1878) (01.12.2010)
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Analysis of Gene Expression in Parkinson's Disease: Possible Involvement of Neurotrophic Support and Axon Guidance in Dopaminergic Cell Death
Bossers, Koen, Meerhoff, Gideon, Balesar, Rawien, Van Dongen, Jeroen W., Kruse, Chris G., Swaab, Dick F., Verhaagen, Joost
Published in Brain pathology (Zurich, Switzerland) (01.01.2009)
Published in Brain pathology (Zurich, Switzerland) (01.01.2009)
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Activation of type-1 cannabinoid receptor shifts the balance between excitation and inhibition towards excitation in layer II/III pyramidal neurons of the rat prelimbic cortex
den Boon, Femke S., Werkman, Taco R., Schaafsma-Zhao, Qiluan, Houthuijs, Kas, Vitalis, Tania, Kruse, Chris G., Wadman, Wytse J., Chameau, Pascal
Published in Pflügers Archiv (01.07.2015)
Published in Pflügers Archiv (01.07.2015)
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Microwave-enhanced Goldberg reaction: a novel route to N-arylpiperazinones and N-arylpiperazinediones
Lange, Jos H.M, Hofmeyer, Lovina J.F, Hout, Floris A.S, Osnabrug, Stefan J.M, Verveer, Peter C, Kruse, Chris G, Feenstra, Rolf W
Published in Tetrahedron letters (04.02.2002)
Published in Tetrahedron letters (04.02.2002)
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Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation
Gelens, E, De Kanter, F J J, Schmitz, R F, Sliedregt, L A J M, Van Steen, B J, Kruse, Chris G, Leurs, R, Groen, M B, Orru, R V A
Published in Molecular diversity (01.02.2006)
Published in Molecular diversity (01.02.2006)
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Assessment of Scaffold Hopping Efficiency by Use of Molecular Interaction Fingerprints
Venhorst, Jennifer, Núñez, Sara, Terpstra, Jan Willem, Kruse, Chris G
Published in Journal of medicinal chemistry (12.06.2008)
Published in Journal of medicinal chemistry (12.06.2008)
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Journal Article
Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons
Baggelaar, Marc P, Chameau, Pascal J. P, Kantae, Vasudev, Hummel, Jessica, Hsu, Ku-Lung, Janssen, Freek, van der Wel, Tom, Soethoudt, Marjolein, Deng, Hui, den Dulk, Hans, Allarà, Marco, Florea, Bogdan I, Di Marzo, Vincenzo, Wadman, Wytse J, Kruse, Chris G, Overkleeft, Herman S, Hankemeier, Thomas, Werkman, Taco R, Cravatt, Benjamin F, van der Stelt, Mario
Published in Journal of the American Chemical Society (15.07.2015)
Published in Journal of the American Chemical Society (15.07.2015)
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Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure–activity relationships, physicochemical properties and biological activity
Blaazer, Antoni R., Lange, Jos H.M., van der Neut, Martina A.W., Mulder, Arie, den Boon, Femke S., Werkman, Taco R., Kruse, Chris G., Wadman, Wytse J.
Published in European journal of medicinal chemistry (01.10.2011)
Published in European journal of medicinal chemistry (01.10.2011)
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Journal Article
Allosteric Inhibition of the Neuropeptidase Neurolysin
Hines, Christina S., Ray, Kallol, Schmidt, Jack J., Xiong, Fei, Feenstra, Rolf W., Pras-Raves, Mia, de Moes, Jan Peter, Lange, Jos H.M., Melikishvili, Manana, Fried, Michael G., Mortenson, Paul, Charlton, Michael, Patel, Yogendra, Courtney, Stephen M., Kruse, Chris G., Rodgers, David W.
Published in The Journal of biological chemistry (19.12.2014)
Published in The Journal of biological chemistry (19.12.2014)
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Endocannabinoids produced upon action potential firing evoke a Cl− current via type-2 cannabinoid receptors in the medial prefrontal cortex
den Boon, Femke S., Chameau, Pascal, Houthuijs, Kas, Bolijn, Simone, Mastrangelo, Nicolina, Kruse, Chris G., Maccarrone, Mauro, Wadman, Wytse J., Werkman, Taco R.
Published in Pflügers Archiv (01.12.2014)
Published in Pflügers Archiv (01.12.2014)
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Spiro-1-benzofuranpiperidinylalkanoic acids as a novel and selective sphingosine S1P5 receptor agonist chemotype
Stoit, Axel R., Lange, Jos H.M., Coolen, Hein K.A.C., Rensink, Annemieke, van den Hoogenband, Adri, den Hartog, Arnold P., van Schaik, Sjoerd, Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
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Assessment of a Novel Scoring Method Based on Solvent Accessible Surface Area Descriptors
Núñez, Sara, Venhorst, Jennifer, Kruse, Chris G
Published in Journal of chemical information and modeling (26.04.2010)
Published in Journal of chemical information and modeling (26.04.2010)
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Journal Article
Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism
Lange, Jos H. M, Coolen, Hein K. A. C, van der Neut, Martina A. W, Borst, Alice J. M, Stork, Bob, Verveer, Peter C, Kruse, Chris G
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB1 Cannabinoid Receptor Antagonists
Lange, Jos H. M, van Stuivenberg, Herman H, Coolen, Hein K. A. C, Adolfs, Tiny J. P, McCreary, Andrew C, Keizer, Hiskias G, Wals, Henri C, Veerman, Willem, Borst, Alice J. M, de Looff, Wouter, Verveer, Peter C, Kruse, Chris G
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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N′-(Arylsulfonyl)pyrazoline-1-carboxamidines as Novel, Neutral 5-Hydroxytryptamine 6 Receptor (5-HT6R) Antagonists with Unique Structural Features
van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I, de Korte, Cor G, de Looff, Wouter, Verhoog, Stefan, van Wees, Jan-Willem, van Hoeve, Martijn, van de Woestijne, Rob P, van der Neut, Martina A. W, Borst, Alice J. M, van Dongen, Maria J. P, de Bruin, Natasja M. W. J, Keizer, Hiskias G, Kruse, Chris G
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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