Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)
Trani, Giancarlo, Barker, John J., Bromidge, Steven M., Brookfield, Frederick A., Burch, Jason D., Chen, Yuan, Eigenbrot, Charles, Heifetz, Alexander, Ismaili, M. Hicham A., Johnson, Adam, Krulle, Thomas M., MacKinnon, Colin H., Maghames, Rosemary, McEwan, Paul A., Montalbetti, Christian A. G. N., Ortwine, Daniel F., Perez-Fuertes, Yolanda, Vaidya, Darshan G., Wang, Xiaolu, Zarrin, Ali A., Pei, Zhonghua
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
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Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)
MacKinnon, Colin H., Lau, Kevin, Burch, Jason D., Chen, Yuan, Dines, Jonathon, Ding, Xiao, Eigenbrot, Charles, Heifetz, Alexander, Jaochico, Allan, Johnson, Adam, Kraemer, Joachim, Kruger, Susanne, Krülle, Thomas M., Liimatta, Marya, Ly, Justin, Maghames, Rosemary, Montalbetti, Christian A.G.N., Ortwine, Daniel F., Pérez-Fuertes, Yolanda, Shia, Steven, Stein, Daniel B., Trani, Giancarlo, Vaidya, Darshan G., Wang, Xiaolu, Bromidge, Steven M., Wu, Lawren C., Pei, Zhonghua
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
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Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa
Ryan, M. Dominic, Parkes, Alastair L, Corbett, David, Dickie, Anthony P, Southey, Michelle, Andersen, Ole A, Stein, Daniel B, Barbeau, Olivier R, Sanzone, Angelo, Thommes, Pia, Barker, John, Cain, Ricky, Compper, Christel, Dejob, Magali, Dorali, Alain, Etheridge, Donnya, Evans, Sian, Faulkner, Adele, Gadouleau, Elise, Gorman, Timothy, Haase, Denes, Holbrow-Wilshaw, Maisie, Krulle, Thomas, Li, Xianfu, Lumley, Christopher, Mertins, Barbara, Napier, Spencer, Odedra, Rajesh, Papadopoulos, Kostas, Roumpelakis, Vasileios, Spear, Kate, Trimby, Emily, Williams, Jennifer, Zahn, Michael, Keefe, Anthony D, Zhang, Ying, Soutter, Holly T, Centrella, Paolo A, Clark, Matthew A, Cuozzo, John W, Dumelin, Christoph E, Deng, Boer, Hunt, Avery, Sigel, Eric A, Troast, Dawn M, DeJonge, Boudewijn L. M
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
Liu, Longbin, Prime, Michael E, Lee, Matt R, Khetarpal, Vinod, Brown, Christopher J, Johnson, Peter D, Miranda-Azpiazu, Patricia, Chen, Xuemei, Clark-Frew, Daniel, Coe, Samuel, Davis, Randall, Dickie, Anthony, Ebneth, Andreas, Esposito, Simone, Gadouleau, Elise, Gai, Xinjie, Galan, Sebastien, Green, Samantha, Greenaway, Catherine, Giles, Paul, Halldin, Christer, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, Heßmann, Manuela, Jia, Zhisheng, Kiselyov, Alexander, Kotey, Adrian, Krulle, Thomas, Mangette, John E, Marston, Richard W, Menta, Sergio, Mills, Matthew R, Monteagudo, Edith, Nag, Sangram, Nibbio, Martina, Orsatti, Laura, Schaertl, Sabine, Scheich, Christoph, Sproston, Joanne, Stepanov, Vladimir, Svedberg, Marie, Takano, Akihiro, Taylor, Malcolm, Thomas, Wayne, Toth, Miklós, Vaidya, Darshan, Vanräs, Katarina, Weddell, Derek, Wigginton, Ian, Wityak, John, Mrzljak, Ladislav, Munoz-Sanjuan, Ignacio, Bard, Jonathan A, Dominguez, Celia
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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5‐HT1A Activation Counteracts Cardiovascular But Not Hypophagic Effects of Sibutramine in Rats
Thomas, Gerard H., Babbs, Adam J., Chatfield, Rosemary E., Krülle, Thomas M., Widdowson, Peter S., Provost, Daniel, McCormack, James G.
Published in Obesity (Silver Spring, Md.) (01.03.2009)
Published in Obesity (Silver Spring, Md.) (01.03.2009)
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Looking glass inhibitors: efficient synthesis and biological evaluation of d-deoxyfuconojirimycin
Blériot, Yves, Gretzke, Dirk, Krülle, Thomas M., Butters, Terry D., Dwek, Raymond A., Nash, Robert J., Asano, Naoki, Fleet, George W.J.
Published in Carbohydrate research (30.12.2005)
Published in Carbohydrate research (30.12.2005)
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5-HT(1A) Activation Counteracts Cardiovascular But Not Hypophagic Effects of Sibutramine in Rats
Thomas, Gerard H, Babbs, Adam J, Chatfield, Rosemary E, Krulle, Thomas M, Widdowson, Peter S, Provost, Daniel, McCormack, James G
Published in Obesity (Silver Spring, Md.) (01.03.2009)
Published in Obesity (Silver Spring, Md.) (01.03.2009)
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PROBES FOR IMAGING HUNTINGTIN PROTEIN
CLARK FREW DANIEL, COE SAMUEL, GILES PAUL RICHARD, KISELYOV ALEX, PRIME MICHAEL EDWARD, WITYAK JOHN, JOHNSON PETER DAVID, BROWN CHRISTOPHER JOHN, GALAN SEBASTIEN RENE GABRIEL, HAYES SARAH, GADOULEAU ELISE LUCIENNEN PAULETTE, DOMINGUEZ CELIA, BARD JONATHAN, KRULLE THOMAS MARTIN
Year of Publication 04.11.2022
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Year of Publication 04.11.2022
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A simple route to 6- and 7-fluoro-substituted naphthalene-1-carboxylic acids
Krülle, Thomas M., Barba, Oscar, Davis, Susan H., Dawson, Graham, Procter, Martin J., Staroske, Thomas, Thomas, Gerard H.
Published in Tetrahedron letters (26.02.2007)
Published in Tetrahedron letters (26.02.2007)
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PAD4의 아자-벤즈이미다졸 억제제
KOTEY ADRIAN, GLEAVE LAURA, WIGGINTON IAN, KUMARAVEL GNANASAMBANDAM, LECCI CRISTINA, DEVRAJ RAJESH, TYE HEATHER, KRULLE THOMAS
Year of Publication 04.09.2018
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Year of Publication 04.09.2018
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PROBES FOR IMAGING HUNTINGTIN PROTEIN
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Year of Publication 04.05.2017
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Year of Publication 04.05.2017
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PARROTT SHELLEY, BROMBRIDGE STEVE, LECCI CRISTINA, LOKE PUI, COOPER SOPHIE, DEVRAJ RAJESH, BOWLES LEE, NORTH CARL, MENICONI MIRCO, PALFREY JORDAN, MONCK NAT, PARKER MICHAEL F, BEAUMONT EDWARD, GADOULEAU ELISE, KOTEY ADRIAN, GLEAVE LAURA, RIDGILL MARK, KUMARAVEL GNANASAMBANDAM, TYE HEATHER, KRULLE THOMAS, KERRY PHILIP
Year of Publication 04.09.2018
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Year of Publication 04.09.2018
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PROBES FOR IMAGING HUNTINGTIN PROTEIN
CLARK FREW DANIEL, COE SAMUEL, GILES PAUL RICHARD, KISELYOV ALEX, PRIME MICHAEL EDWARD, WITYAK JOHN, JOHNSON PETER DAVID, BROWN CHRISTOPHER JOHN, GALAN SEBASTIEN RENE GABRIEL, HAYES SARAH, GADOULEAU ELISE LUCIENNEN PAULETTE, DOMINGUEZ CELIA, BARD JONATHAN, KRULLE THOMAS MARTIN
Year of Publication 28.04.2017
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Year of Publication 28.04.2017
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PROBES FOR IMAGING HUNTINGTIN PROTEIN
CLARK FREW DANIEL, WALTER DARYL SIMON, GILES PAUL RICHARD, PRIME MICHAEL EDWARD, WITYAK JOHN, JOHNSON PETER DAVID, BROWN CHRISTOPHER JOHN, WEDDELL DEREK ALEXANDER, WIGGINTON IAN JAMES, GALAN SEBASTIEN RENE GABRIEL, MORAO INAKI, DOMINGUEZ CELIA, BARD JONATHAN, TAYLOR MALCOLM GEORGE, KRULLE THOMAS MARTIN
Year of Publication 04.05.2017
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Year of Publication 04.05.2017
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Stereospecific synthesis of spirohydantoins of beta-glucopyranose: Inhibitors of glycogen phosphorylase
Krulle, TM, delaFuente, C, Watson, KA, Gregoriou, M, Johnson, LN, Tsitsanou, KE, Zographos, SE, Oikonomakos, NG, Fleet, GWJ
Published in Synlett (01.02.1997)
Published in Synlett (01.02.1997)
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The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 Å resolution and 100 K: The role of the water structure and its contribution to binding
Gregoriou, Mary, Noble, Martin E. M., Watson, Kimberly A., Garman, Elspeth F., Johnson, Louise N., Krulle, Thomas M., Fuetene, Carmen De La, Fleet, George W.J., Oikonomakos, Nikos G.
Published in Protein science (01.04.1998)
Published in Protein science (01.04.1998)
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PIPERIDINYL GPCR AGONISTS
FYFE MATTHEW COLIN THOR, RASAMISON CHRYSTELLE MARIE, KEILY JOHN, JEEVARATNAM REVATHY PERPETUA, SAMBROOK SMITH COLIN PETER, SWAIN SIMON ANDREW, BERTRAM LISA SARAH, KRULLE THOMAS MARTIN
Year of Publication 07.04.2011
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Year of Publication 07.04.2011
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