A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia
Evans, Mark J, Mahaney, Paige E, Borges-Marcucci, Lisa, Lai, KehDih, Wang, Shuguang, Krueger, Julie A, Gardell, Stephen J, Huard, Christine, Martinez, Robert, Vlasuk, George P, Harnish, Douglas C
Published in American journal of physiology: Gastrointestinal and liver physiology (01.03.2009)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.03.2009)
Get full text
Journal Article
The Gap Junction Modifier, GAP-134 [(2S,4R)-1-(2-Aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic Acid], Improves Conduction and Reduces Atrial Fibrillation/Flutter in the Canine Sterile Pericarditis Model
Rossman, Eric I, Liu, Kun, Morgan, Gwen A, Swillo, Robert E, Krueger, Julie A, Gardell, Stephen J, Butera, John, Gruver, Matthew, Kantrowitz, Joel, Feldman, Hal S, Petersen, Jørgen S, Haugan, Ketil, Hennan, James K
Published in The Journal of pharmacology and experimental therapeutics (01.06.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2009)
Get full text
Journal Article
Neutralization of Plasminogen Activator Inhibitor I (PAI-1) by the Synthetic Antagonist PAI-749 via a Dual Mechanism of Action
Gardell, Stephen J, Krueger, Julie A, Antrilli, Thomas A, Elokdah, Hassan, Mayer, Scott, Orcutt, Steven J, Crandall, David L, Vlasuk, George P
Published in Molecular pharmacology (01.10.2007)
Published in Molecular pharmacology (01.10.2007)
Get full text
Journal Article
A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site
Hardwicke, Mary Ann, Rendina, Alan R, Williams, Shawn P, Moore, Michael L, Wang, Liping, Krueger, Julie A, Plant, Ramona N, Totoritis, Rachel D, Zhang, Guofeng, Briand, Jacques, Burkhart, William A, Brown, Kristin K, Parrish, Cynthia A
Published in Nature chemical biology (01.09.2014)
Published in Nature chemical biology (01.09.2014)
Get full text
Journal Article
Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines
Burgey, Christopher S, Robinson, Kyle A, Lyle, Terry A, Sanderson, Philip E. J, Lewis, S. Dale, Lucas, Bobby J, Krueger, Julie A, Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B, Wong, Bradley, Lyle, Elizabeth A, Williams, Peter D, Coburn, Craig A, Dorsey, Bruce D, Barrow, James C, Stranieri, Maria T, Holahan, Marie A, Sitko, Gary R, Cook, Jacquelynn J, McMasters, Daniel R, McDonough, Colleen M, Sanders, William M, Wallace, Audrey A, Clayton, Franklin C, Bohn, Dennis, Leonard, Yvonne M, Detwiler, Theodore J, Lynch, Joseph J, Yan, Youwei, Chen, Zhongguo, Kuo, Lawrence, Gardell, Stephen J, Shafer, Jules A, Vacca, Joseph P
Published in Journal of medicinal chemistry (13.02.2003)
Published in Journal of medicinal chemistry (13.02.2003)
Get full text
Journal Article
Cyclopropylamino Acid Amide as a Pharmacophoric Replacement for 2,3-Diaminopyridine. Application to the Design of Novel Bradykinin B1 Receptor Antagonists
Wood, Michael R, Schirripa, Kathy M, Kim, June J, Wan, Bang-Lin, Murphy, Kathy L, Ransom, Richard W, Chang, Raymond S. L, Tang, Cuyue, Prueksaritanont, Thomayant, Detwiler, Theodore J, Hettrick, Lisa A, Landis, Elizabeth R, Leonard, Yvonne M, Krueger, Julie A, Lewis, Sidney D, Pettibone, Douglas J, Freidinger, Roger M, Bock, Mark G
Published in Journal of medicinal chemistry (23.02.2006)
Published in Journal of medicinal chemistry (23.02.2006)
Get full text
Journal Article
Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors
Isaacs, Richard C.A., Newton, Christina L., Cutrona, Kellie J., Mercer, Swati P., Payne, Linda S., Stauffer, Kenneth J., Williams, Peter D., Cook, Jacquelynn J., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., McMasters, Daniel R., Naylor-Olsen, Adel M., Michener, Maria T., Wallace, Audrey A.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Get full text
Journal Article
Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization
Deng, James Z., McMasters, Daniel R., Rabbat, Philippe M.A., Williams, Peter D., Coburn, Craig A., Yan, Youwei, Kuo, Lawrence C., Lewis, S. Dale, Lucas, Bobby J., Krueger, Julie A., Strulovici, Berta, Vacca, Joseph P., Lyle, Terry A., Burgey, Christopher S.
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
Get full text
Journal Article
P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position
Isaacs, Richard C.A., Newton, Christina L., Cutrona, Kellie J., Mercer, Swati P., Dorsey, Bruce D., McDonough, Colleen M., Cook, Jacquelynn J., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Miller-Stein, Cynthia, Michener, Maria T., Wallace, Audrey A., White, Rebecca B., Wong, Bradley K.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Get full text
Journal Article
Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability
Staas, Donnette D., Savage, Kelly L., Sherman, Vanessa L., Shimp, Heidi L., Lyle, Terry A., Tran, Lekhanh O., Wiscount, Catherine M., McMasters, Daniel R., Sanderson, Philip E.J., Williams, Peter D., Lucas, Bobby J., Krueger, Julie A., Dale Lewis, S., White, Rebecca B., Yu, Sean, Wong, Bradley K., Kochansky, Christopher J., Reza Anari, M., Yan, Youwei, Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry (15.10.2006)
Published in Bioorganic & medicinal chemistry (15.10.2006)
Get full text
Journal Article
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles
Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., McMasters, Daniel R., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Kuo, Lawrence C., Yan, Youwei, Lynch, J.J., Lyle, E.A.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
Get full text
Journal Article
9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors
Stauffer, Kenneth J, Williams, Peter D, Selnick, Harold G, Nantermet, Philippe G, Newton, Christina L, Homnick, Carl F, Zrada, Matthew M, Lewis, S. Dale, Lucas, Bobby J, Krueger, Julie A, Pietrak, Beth L, Lyle, Elizabeth A, Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B, Wong, Bradley, Wallace, Audrey A, Sitko, Gary R, Cook, Jacquelyn J, Holahan, Marie A, Stranieri-Michener, Maria, Leonard, Yvonne M, Lynch, Joseph J, McMasters, Daniel R, Yan, Youwei
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
Get full text
Journal Article
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles
Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Get full text
Journal Article
Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. implementation of P3 pyridine N-Oxides to deliver an orally bioavailable series containing P1 N-Benzylamides
Burgey, Christopher S., Robinson, Kyle A., Lyle, Terry A., Nantermet, Philippe G., Selnick, Harold G., Isaacs, Richard C.A., Lewis, S.Dale, Lucas, Bobby J., Krueger, Julie A., Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B., Wong, Bradley, Lyle, Elizabeth A., Stranieri, Maria T., Cook, Jacquelynn J., McMasters, Daniel R., Pellicore, Janetta M., Pal, Swati, Wallace, Audrey A., Clayton, Franklin C., Bohn, Dennis, Welsh, Denise C., Lynch, Joseph J., Yan, Youwei, Chen, Zhongguo, Kuo, Lawrence, Gardell, Stephen J., Shafer, Jules A., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Get full text
Journal Article
Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the ‘Distal binding pocket’
Sanderson, Philip E.J., Cutrona, Kellie J., Dyer, Dona L., Krueger, Julie A., Kuo, Lawrence C., Lewis, S.Dale, Lucas, Bobby J., Yan, Youwei
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
Get full text
Journal Article
P2 pyridine N-oxide thrombin inhibitors : a novel peptidomimetic scaffold
NANTERMET, Philippe G, BURGEY, Christopher S, MILLER-STEIN, Cynthia, WHITE, Rebecca B, WONG, Bradley, MCMASTERS, Daniel R, WALLACE, Audrey A, LYNCH, Joseph J, YOUWEI YAN, ZHONGGUO CHEN, KUO, Lawrence, GARDELL, Stephen J, ROBINSON, Kyle A, SHAFER, Jules A, VACCA, Joseph P, LYLE, Terry A, PELLICORE, Janetta M, NEWTON, Christina L, DENG, James Z, SELNICK, Harold G, LEWIS, S. Dale, LUCAS, Bobby J, KRUEGER, Julie A
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Get full text
Journal Article
Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position
RITTLE, Kenneth E, BARROW, James C, NANTERMET, Philippe G, NEWTON, Christina L, SANDERS, William M, YOUWEI YAN, VACCA, Joseph P, SELNICK, Harold G, CUTRONA, Kellie J, GLASS, Kristen L, KRUEGER, Julie A, KUO, Lawrence C, LEWIS, S. Dale, LUCAS, Bobby J, MCMASTERS, Daniel R, MORRISSETTE, Matthew M
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Get full text
Journal Article
Azaindoles: moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors
Sanderson, Philip E.J., Stanton, Matthew G., Dorsey, Bruce D., Lyle, Terry A., McDonough, Colleen, Sanders, William M., Savage, Kelly L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S.Dale, Lucas, Bobby J., Lynch, Joseph J., Yan, Youwei
Published in Bioorganic & medicinal chemistry letters (10.03.2003)
Published in Bioorganic & medicinal chemistry letters (10.03.2003)
Get full text
Journal Article