Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies
Kroth, Heiko, Oden, Felix, Molette, Jerome, Schieferstein, Hanno, Capotosti, Francesca, Mueller, Andre, Berndt, Mathias, Schmitt-Willich, Heribert, Darmency, Vincent, Gabellieri, Emanuele, Boudou, Cédric, Juergens, Tanja, Varisco, Yvan, Vokali, Efthymia, Hickman, David T., Tamagnan, Gilles, Pfeifer, Andrea, Dinkelborg, Ludger, Muhs, Andreas, Stephens, Andrew
Published in European journal of nuclear medicine and molecular imaging (01.09.2019)
Published in European journal of nuclear medicine and molecular imaging (01.09.2019)
Get full text
Journal Article
PRECLINICAL CHARACTERIZATION OF PI-2620, A NOVEL TAU PET TRACER FOR DETECTION OF TAU IN AD AND OTHER TAUOPATHIES
Mueller, Andre, Kroth, Heiko, Schieferstein, Hanno, Berndt, Mathias, Oden, Felix, Capotosti, Francesca, Molette, Jerome, Juergens, Tanja, Darmency, Vincent, Schmitt-Willich, Heribert, Hickman, David, Tamagnan, Gilles, Pfeifer, Andrea, Dinkelborg, Ludger, Muhs, Andreas, Stephens, Andrew
Published in Alzheimer's & dementia (01.07.2017)
Published in Alzheimer's & dementia (01.07.2017)
Get full text
Journal Article
Target-Induced Formation of Neuraminidase Inhibitors from in vitro Virtual Combinatorial Libraries
Hochgürtel, Matthias, Kroth, Heiko, Piecha, Dorothea, Hofmann, Michael W., Nicolau, Claude, Krause, Sonja, Schaaf, Otmar, Sonnenmoser, Gabriele, Eliseev, Alexey V.
Published in Proceedings of the National Academy of Sciences - PNAS (19.03.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (19.03.2002)
Get full text
Journal Article
Ketones as Building Blocks for Dynamic Combinatorial Libraries: Highly Active Neuraminidase Inhibitors Generated via Selection Pressure of the Biological Target
Hochgürtel, Matthias, Biesinger, Ralf, Kroth, Heiko, Piecha, Dorothea, Hofmann, Michael W, Krause, Sonja, Schaaf, Otmar, Nicolau, Claude, Eliseev, Alexey V
Published in Journal of medicinal chemistry (30.01.2003)
Published in Journal of medicinal chemistry (30.01.2003)
Get full text
Journal Article
Efficiency and Accuracy of SOS-induced DNA Polymerases Replicating Benzo[a]pyrene-7,8-diol 9,10-Epoxide A and G Adducts
Shen, Xuan, Sayer, Jane M, Kroth, Heiko, Ponten, Ingrid, O'Donnell, Mike, Woodgate, Roger, Jerina, Donald M, Goodman, Myron F
Published in The Journal of biological chemistry (15.02.2002)
Published in The Journal of biological chemistry (15.02.2002)
Get full text
Journal Article
Trapping HIV-1 Reverse Transcriptase Before and After Translocation on DNA
Sarafianos, Stefan G., Clark, Arthur D., Tuske, Steve, Squire, Christopher J., Das, Kalyan, Sheng, Dequan, Ilankumaran, Palanichamy, Ramesha, Andagar R., Kroth, Heiko, Sayer, Jane M., Jerina, Donald M., Boyer, Paul L., Hughes, Stephen H., Arnold, Eddy
Published in The Journal of biological chemistry (02.05.2003)
Published in The Journal of biological chemistry (02.05.2003)
Get full text
Journal Article
Position-Specific Trapping of Topoisomerase II by Benzo[a]pyrene Diol Epoxide Adducts: Implications for Interactions with Intercalating Anticancer Agents
Khan, Qasim A., Kohlhagen, Glenda, Marshall, Richard, Austin, Caroline A., Kalena, Govind P., Kroth, Heiko, Sayer, Jane M., Jerina, Donald M., Pommier, Yves
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2003)
Get full text
Journal Article
Benzo[a]pyrene Diol Epoxide Adducts in DNA Are Potent Suppressors of a Normal Topoisomerase I Cleavage Site and Powerful Inducers of other Topoisomerase I Cleavages
Pommier, Yves, Kohlhagen, Glenda, Pourquier, Philippe, Sayer, Jane M., Kroth, Heiko, Jerina, Donald M.
Published in Proceedings of the National Academy of Sciences - PNAS (29.02.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (29.02.2000)
Get full text
Journal Article
Position-Specific Trapping of Topoisomerase I-DNA Cleavage Complexes by Intercalated Benzo[a]-Pyrene Diol Epoxide Adducts at the 6-Amino Group of Adenine
Pommier, Yves, Laco, Gary S., Kohlhagen, Glenda, Sayer, Jane M., Kroth, Heiko, Jerina, Donald M.
Published in Proceedings of the National Academy of Sciences - PNAS (26.09.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (26.09.2000)
Get full text
Journal Article
Different Effects on Human Topoisomerase I by Minor Groove and Intercalated Deoxyguanosine Adducts Derived from Two Polycyclic Aromatic Hydrocarbon Diol Epoxides at or Near a Normal Cleavage Site
Pommier, Yves, Kohlhagen, Glenda, Laco, Gary S., Kroth, Heiko, Sayer, Jane M., Jerina, Donald M.
Published in The Journal of biological chemistry (19.04.2002)
Published in The Journal of biological chemistry (19.04.2002)
Get full text
Journal Article
Benzo[a]pyrene-dG Adduct Interference Illuminates the Interface of Vaccinia Topoisomerase with the DNA Minor Groove
Tian, Ligeng, Sayer, Jane M, Kroth, Heiko, Kalena, Govind, Jerina, Donald M, Shuman, Stewart
Published in The Journal of biological chemistry (14.03.2003)
Published in The Journal of biological chemistry (14.03.2003)
Get full text
Journal Article
Inhibition of Werner Syndrome Helicase Activity by Benzo[c]phenanthrene Diol Epoxide dA Adducts in DNA Is Both Strand-and Stereoisomer-dependent
Driscoll, Henry C., Matson, Steven W., Sayer, Jane M., Kroth, Heiko, Jerina, Donald M., Brosh, Robert M.
Published in The Journal of biological chemistry (17.10.2003)
Published in The Journal of biological chemistry (17.10.2003)
Get full text
Journal Article
Site-specific DNA Transesterification by Vaccinia Topoisomerase
Yakovleva, Lyudmila, Tian, Ligeng, Sayer, Jane M., Kalena, Govind P., Kroth, Heiko, Jerina, Donald M., Shuman, Stewart
Published in The Journal of biological chemistry (24.10.2003)
Published in The Journal of biological chemistry (24.10.2003)
Get full text
Journal Article
Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core
Kroth, Heiko, Oden, Felix, Serra, Andreia Monica, Molette, Jerome, Mueller, Andre, Berndt, Mathias, Capotosti, Francesca, Gabellieri, Emanuele, Schmitt-Willich, Heribert, Hickman, David, Pfeifer, Andrea, Dinkelborg, Ludger, Stephens, Andrew
Published in Bioorganic & medicinal chemistry (15.12.2021)
Published in Bioorganic & medicinal chemistry (15.12.2021)
Get full text
Journal Article
Cross-Linking of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Template-Primer
Peletskaya, E N, Boyer, P L, Kogon, A A, Clark, P, Kroth, H, Sayer, J M, Jerina, D M, Hughes, S H
Published in Journal of Virology (01.10.2001)
Published in Journal of Virology (01.10.2001)
Get full text
Journal Article
PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer’s Disease and Other Tauopathies
Kroth, Heiko, Oden, Felix, Molette, Jerome, Schieferstein, Hanno, Gabellieri, Emanuele, Mueller, Andre, Berndt, Mathias, Sreenivasachary, Nampally, Serra, Andreia Monica, Capotosti, Francesca, Schmitt-Willich, Heribert, Hickman, David, Pfeifer, Andrea, Dinkelborg, Ludger, Stephens, Andrew
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
Get full text
Journal Article
Discovery and optimization of the first‐in‐class TDP‐43 PET tracer
Seredenina, Tamara, Vokali, Efthymia, Dreyfus, Nicolas, Chevallier, Elodie, Afroz, Tariq, Jaquier, Thomas, Serra, Andreia Monica, Clavel, Mathieu, Rathnam, Monisha, Melly, Tania, Kroth, Heiko, Pfeifer, Andrea, Kosco‐Vilbois, Marie
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
Get full text
Journal Article
A Short Synthesis of the 2‑Bromo‑N,9-dimethyl-6,7,8,9-tetrahydro‑5H‑pyrido[2,3‑b]indol-6-amine Building Block
Sreenivasachary, Nampally, Kroth, Heiko, Benderitter, Pascal, Barth, Wolfgang, Pfeifer, Andrea, Muhs, Andreas
Published in Organic process research & development (15.11.2019)
Published in Organic process research & development (15.11.2019)
Get full text
Journal Article
A Short Synthesis of the 2-Bromo- N ,9-dimethyl-6,7,8,9-tetrahydro-5 H -pyrido[2,3- b ]indol-6-amine Building Block
Sreenivasachary, Nampally, Kroth, Heiko, Benderitter, Pascal, Barth, Wolfgang, Pfeifer, Andrea, Muhs, Andreas
Published in Organic process research & development (15.11.2019)
Published in Organic process research & development (15.11.2019)
Get full text
Journal Article
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models
Baragi, Vijaykumar M., Becher, Gabriel, Bendele, Alison M., Biesinger, Ralf, Bluhm, Harald, Boer, Jürgen, Deng, Hongbo, Dodd, Rory, Essers, Michael, Feuerstein, Tim, Gallagher, Brian M., Gege, Christian, Hochgürtel, Matthias, Hofmann, Michael, Jaworski, Andreas, Jin, Lixia, Kiely, Andrew, Korniski, Brian, Kroth, Heiko, Nix, Darrell, Nolte, Bert, Piecha, Dorothea, Powers, Timothy S., Richter, Frank, Schneider, Matthias, Steeneck, Christoph, Sucholeiki, Irving, Taveras, Arthur, Timmermann, Andreas, Van Veldhuizen, Joshua, Weik, Juergen, Wu, Xinyuan, Xia, Bing
Published in Arthritis and rheumatism (01.07.2009)
Published in Arthritis and rheumatism (01.07.2009)
Get full text
Journal Article