Structural basis for isoform-specific inhibition of human CTPS1
Lynch, Eric M., DiMattia, Michael A., Albanese, Steven, van Zundert, Gydo C. P., Hansen, Jesse M., Quispe, Joel D., Kennedy, Madison A., Verras, Andreas, Borrelli, Kenneth, Toms, Angela V., Kaila, Neelu, Kreutter, Kevin D., McElwee, Joshua J., Kollman, Justin M.
Published in Proceedings of the National Academy of Sciences - PNAS (05.10.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (05.10.2021)
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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease
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Published in Journal of medicinal chemistry (26.03.2020)
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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt
Kummer, David A., Cummings, Maxwell D., Abad, Marta, Barbay, Joseph, Castro, Glenda, Wolin, Ronald, Kreutter, Kevin D., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
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Journal Article
6-Substituted quinolines as RORγt inverse agonists
Barbay, J. Kent, Cummings, Maxwell D., Abad, Marta, Castro, Glenda, Kreutter, Kevin D., Kummer, David A., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Tanis, Virginia M., Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Wolin, Ronald, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article
Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity
Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors
Lee, Lily, Kreutter, Kevin D., Pan, Wenxi, Crysler, Carl, Spurlino, John, Player, Mark R., Tomczuk, Bruce, Lu, Tianbao
Published in Bioorganic & medicinal chemistry (15.11.2007)
Published in Bioorganic & medicinal chemistry (15.11.2007)
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Journal Article
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif
Kreutter, Kevin D., Lu, Tianbao, Lee, Lily, Giardino, Edward C., Patel, Sharmila, Huang, Hui, Xu, Guozhang, Fitzgerald, Mark, Haertlein, Barbara J., Mohan, Venkatraman, Crysler, Carl, Eisennagel, Stephen, Dasgupta, Malini, McMillan, Martin, Spurlino, John C., Huebert, Norman D., Maryanoff, Bruce E., Tomczuk, Bruce E., Damiano, Bruce P., Player, Mark R.
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
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KEAP1-Nrf2 INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION
HIRST GAVIN C, MCCLURE KELLY J, KREUTTER KEVIN D, VENKATESAN HARIHARAN, CHAI WENYING, VENABLE JENNIFER D, NISHIMURA RACHEL T, SHIH AMY Y, BARBAY J. KENT, WEI JIANMEI, KUMMER DAVID A
Year of Publication 18.10.2023
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Year of Publication 18.10.2023
Patent
NF-kB 유도 키나아제의 소분자 억제제
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Year of Publication 08.03.2022
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Year of Publication 08.03.2022
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JAK 패밀리의 키나제의 소분자 억제제
LEONARD KRISTI, KREUTTER KEVIN D, KOUDRIAKOVA TATIANA, TICHENOR MARK S, RIZZOLIO MICHELE C, WANG AIHUA, SMITH RUSSELL C
Year of Publication 23.07.2019
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Year of Publication 23.07.2019
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KEAP1-Nrf2 단백질간 상호작용 억제제
HIRST GAVIN C, MCCLURE KELLY J, KREUTTER KEVIN D, VENKATESAN HARIHARAN, CHAI WENYING, VENABLE JENNIFER D, NISHIMURA RACHEL T, SHIH AMY Y, BARBAY J. KENT, WEI JIANMEI, KUMMER DAVID A
Year of Publication 30.04.2021
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Year of Publication 30.04.2021
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MALT1 억제제로서의 피라졸 유도체
KREUTTER KEVIN D, EDWARDS JAMES PATRICK, WU TONGFEI, DIELS GASTON STANISLAS MARCELLA, PHILIPPAR ULRIKE, SHEN FANG, CONNOLLY PETER J, BARBAY JOSEPH KENT, THURING JAN WILLEM, LU TIANBAO, CUMMINGS MAXWELL DAVID
Year of Publication 05.03.2021
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Year of Publication 05.03.2021
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MALT1 억제제로서의 피라졸 유도체
KREUTTER KEVIN D, EDWARDS JAMES PATRICK, BERTHELOT DIDIER JEAN CLAUDE, SHEN FANG, ALLISON BRETT DOUGLAS, THURING JOHANNES WILHELMUS JOHN FITZGERALD, WU TONGFEI, PHILIPPAR ULRIKE, BARBAY JOSEPH KENT, CONNOLLY PETER J, DIELS GASTON, LU TIANBAO, CUMMINGS MAXWELL DAVID
Year of Publication 09.08.2019
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Year of Publication 09.08.2019
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JAK 패밀리의 키나제의 억제제로서의 이미다조피롤로피리딘
LEONARD KRISTI, KREUTTER KEVIN D, CHAI WENYING, SEIERSTAD MARK, BACANI GENESIS M, KOUDRIAKOVA TATIANA, TICHENOR MARK S, VENABLE JENNIFER D, RIZZOLIO MICHELE C, SMITH RUSSEL C, KRAWCZUK PAUL J, WANG AIHUA
Year of Publication 07.08.2019
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Year of Publication 07.08.2019
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HETEROARYL LINKED QUINOLINYL MODULATORS OF RORΓT
KREUTTER KEVIN D, VENKATESAN HARIHARAN, LEONARD KRISTI A, NISHIMURA RACHEL, BARBAY KENT, WOODS CRAIG R, EDWARDS JAMES P, XUE XIAOHUA, FOURIE ANNE, CUMMINGS MAXWELL D, URBANSKI MAUD, MAHAROOF UMAR, WANG AIHUA, KUMMER DAVID A, WOLIN RONALD L
Year of Publication 20.06.2016
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Year of Publication 20.06.2016
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ALKYL LINKED QUINOLINYL MODULATORS OF RORYT
KREUTTER KEVIN D, VENKATESAN HARIHARAN, LEONARD KRISTI A, NISHIMURA RACHEL, BARBAY KENT, WOODS CRAIG R, EDWARDS JAMES P, XUE XIAOHUA, FOURIE ANNE, CUMMINGS MAXWELL D, URBANSKI MAUD, MAHAROOF UMAR, WANG AIHUA, KUMMER DAVID A, WOLIN RONALD L
Year of Publication 17.06.2016
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Year of Publication 17.06.2016
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QUINOLINYL MODULATORS OF RORYT
MCCLURE KELLY, KREUTTER KEVIN D, VENKATESAN HARIHARAN, LEONARD KRISTI A, NISHIMURA RACHEL, BARBAY KENT, WOODS CRAIG R, EDWARDS JAMES P, XUE XIAOHUA, FOURIE ANNE, TANIS VIRGINIA, CUMMINGS MAXWELL D, URBANSKI MAUD, MAHAROOF UMAR, WANG AIHUA, KUMMER DAVID A, WOLIN RONALD L
Year of Publication 15.06.2016
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Year of Publication 15.06.2016
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PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T
KREUTTER KEVIN D, VENKATESAN HARIHARAN, LEONARD KRISTI A, NISHIMURA RACHEL, BARBAY KENT, WOODS CRAIG R, EDWARDS JAMES P, XUE XIAOHUA, FOURIE ANNE, CUMMINGS MAXWELL D, URBANSKI MAUD, MAHAROOF UMAR, WANG AIHUA, KUMMER DAVID A, WOLIN RONALD L
Year of Publication 15.06.2016
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Year of Publication 15.06.2016
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SECONDARY ALCOHOL QUINOLINYL MODULATORS OF RORYT
KREUTTER KEVIN D, VENKATESAN HARIHARAN, LEONARD KRISTI A, NISHIMURA RACHEL, BARBAY KENT, WOODS CRAIG R, EDWARDS JAMES P, XUE XIAOHUA, FOURIE ANNE, CUMMINGS MAXWELL D, URBANSKI MAUD, MAHAROOF UMAR, WANG AIHUA, KUMMER DAVID A, WOLIN RONALD L
Year of Publication 15.06.2016
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Year of Publication 15.06.2016
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