Structural basis for isoform-specific inhibition of human CTPS1
Lynch, Eric M., DiMattia, Michael A., Albanese, Steven, van Zundert, Gydo C. P., Hansen, Jesse M., Quispe, Joel D., Kennedy, Madison A., Verras, Andreas, Borrelli, Kenneth, Toms, Angela V., Kaila, Neelu, Kreutter, Kevin D., McElwee, Joshua J., Kollman, Justin M.
Published in Proceedings of the National Academy of Sciences - PNAS (05.10.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (05.10.2021)
Get full text
Journal Article
Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease
Leonard, Kristi A, Madge, Lisa A, Krawczuk, Paul J, Wang, Aihua, Kreutter, Kevin D, Bacani, Genesis M, Chai, Wenying, Smith, Russell C, Tichenor, Mark S, Harris, Michael C, Malaviya, Ravi, Seierstad, Mark, Johnson, Marguerite E, Venable, Jennifer D, Kim, Suzie, Hirst, Gavin C, Mathur, Ashok S, Rao, Tadimeti S, Edwards, James P, Rizzolio, Michele C, Koudriakova, Tatiana
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
Get full text
Journal Article
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
Get full text
Journal Article
Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt
Kummer, David A., Cummings, Maxwell D., Abad, Marta, Barbay, Joseph, Castro, Glenda, Wolin, Ronald, Kreutter, Kevin D., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
Get full text
Journal Article
6-Substituted quinolines as RORγt inverse agonists
Barbay, J. Kent, Cummings, Maxwell D., Abad, Marta, Castro, Glenda, Kreutter, Kevin D., Kummer, David A., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Tanis, Virginia M., Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Wolin, Ronald, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Get full text
Journal Article
Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity
Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
Get full text
Journal Article
2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors
Lee, Lily, Kreutter, Kevin D., Pan, Wenxi, Crysler, Carl, Spurlino, John, Player, Mark R., Tomczuk, Bruce, Lu, Tianbao
Published in Bioorganic & medicinal chemistry (15.11.2007)
Published in Bioorganic & medicinal chemistry (15.11.2007)
Get full text
Journal Article
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif
Kreutter, Kevin D., Lu, Tianbao, Lee, Lily, Giardino, Edward C., Patel, Sharmila, Huang, Hui, Xu, Guozhang, Fitzgerald, Mark, Haertlein, Barbara J., Mohan, Venkatraman, Crysler, Carl, Eisennagel, Stephen, Dasgupta, Malini, McMillan, Martin, Spurlino, John C., Huebert, Norman D., Maryanoff, Bruce E., Tomczuk, Bruce E., Damiano, Bruce P., Player, Mark R.
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
Get full text
Journal Article
Discovery and characterization of novel inhibitors of CTP synthase 1 (CTPS1) for the treatment of autoimmune and inflammatory disease
McElwee, Joshua J, Kaila, Neelu, Carreiro, Samantha, Kumar, Sheetal, Toms, Angela V, Phadke, Avinash, Jacques, Suzanne, Caravella, Justin A, Kreutter, Kevin, Campos, Sebastien, Verras, Andreas, Albanese, Steven K, Demarco, Kevin R, DiMattia, Michael A, Lynch, Eric, Kollman, Justin, Tummino, Peter
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
Get full text
Journal Article
KEAP1-Nrf2 INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION
HIRST GAVIN C, MCCLURE KELLY J, KREUTTER KEVIN D, VENKATESAN HARIHARAN, CHAI WENYING, VENABLE JENNIFER D, NISHIMURA RACHEL T, SHIH AMY Y, BARBAY J. KENT, WEI JIANMEI, KUMMER DAVID A
Year of Publication 18.10.2023
Get full text
Year of Publication 18.10.2023
Patent
A novel reagent combination for the oxidation of highly electron deficient pyridines to N-oxides: trifluoromethanesulfonic anhydride/sodium percarbonate
Zhu, Xizhen, Kreutter, Kevin D., Hu, Huaping, Player, Mark R., Gaul, Micheal D.
Published in Tetrahedron letters (28.01.2008)
Published in Tetrahedron letters (28.01.2008)
Get full text
Journal Article
NF-kB 유도 키나아제의 소분자 억제제
KREUTTER KEVIN D, CHAI WENYING, LEBSACK ALEC D, PIPPEL DANIEL J, HERRMANN AARON T, ROVIRA ALEXANDER R, HACK MICHAEL D, BARBAY J. KENT, ECCLES WENDY, JONES WILLIAM M, KRAWCZUK PAUL J, WOLIN RONALD L
Year of Publication 08.03.2022
Get full text
Year of Publication 08.03.2022
Patent
Stereochemical Dependence of Base-Catalyzed Cleavage of Cyclic Peroxy Ketals
Snider, Barry B, Shi, Zhongping, O'Neil, Steven V, Kreutter, Kevin D, Arakaki, Tracy L
Published in Journal of organic chemistry (01.04.1994)
Published in Journal of organic chemistry (01.04.1994)
Get full text
Journal Article
JAK 패밀리의 키나제의 소분자 억제제
LEONARD KRISTI, KREUTTER KEVIN D, KOUDRIAKOVA TATIANA, TICHENOR MARK S, RIZZOLIO MICHELE C, WANG AIHUA, SMITH RUSSELL C
Year of Publication 23.07.2019
Get full text
Year of Publication 23.07.2019
Patent
KEAP1-Nrf2 단백질간 상호작용 억제제
HIRST GAVIN C, MCCLURE KELLY J, KREUTTER KEVIN D, VENKATESAN HARIHARAN, CHAI WENYING, VENABLE JENNIFER D, NISHIMURA RACHEL T, SHIH AMY Y, BARBAY J. KENT, WEI JIANMEI, KUMMER DAVID A
Year of Publication 30.04.2021
Get full text
Year of Publication 30.04.2021
Patent
MALT1 억제제로서의 피라졸 유도체
KREUTTER KEVIN D, EDWARDS JAMES PATRICK, WU TONGFEI, DIELS GASTON STANISLAS MARCELLA, PHILIPPAR ULRIKE, SHEN FANG, CONNOLLY PETER J, BARBAY JOSEPH KENT, THURING JAN WILLEM, LU TIANBAO, CUMMINGS MAXWELL DAVID
Year of Publication 05.03.2021
Get full text
Year of Publication 05.03.2021
Patent
MALT1 억제제로서의 피라졸 유도체
KREUTTER KEVIN D, EDWARDS JAMES PATRICK, BERTHELOT DIDIER JEAN CLAUDE, SHEN FANG, ALLISON BRETT DOUGLAS, THURING JOHANNES WILHELMUS JOHN FITZGERALD, WU TONGFEI, PHILIPPAR ULRIKE, BARBAY JOSEPH KENT, CONNOLLY PETER J, DIELS GASTON, LU TIANBAO, CUMMINGS MAXWELL DAVID
Year of Publication 09.08.2019
Get full text
Year of Publication 09.08.2019
Patent
JAK 패밀리의 키나제의 억제제로서의 이미다조피롤로피리딘
LEONARD KRISTI, KREUTTER KEVIN D, CHAI WENYING, SEIERSTAD MARK, BACANI GENESIS M, KOUDRIAKOVA TATIANA, TICHENOR MARK S, VENABLE JENNIFER D, RIZZOLIO MICHELE C, SMITH RUSSEL C, KRAWCZUK PAUL J, WANG AIHUA
Year of Publication 07.08.2019
Get full text
Year of Publication 07.08.2019
Patent
브루톤 티로신 키나제 억제제 및 이의 사용 방법
CHEN WEI, XIAO KUN, TICHENOR MARK S, ARORA NIDHI, ZHANG FEIHUANG, WEI JIANMEI, KREUTTER KEVIN, WIENER JOHN J. M, EDWARDS JAMES P, ZHANG ZHENG, BACANI GENESIS M, CAI MIN, DECKHUT CHARLOTTE POOLEY, VENABLE JENNIFER D, ZHU YAOPING, BEMBENEK SCOTT D, GHOSH BRAHMANANDA, WU YAO, BARBAY JOSEPH KENT, LI GANG, HAO BAOYU
Year of Publication 23.08.2018
Get full text
Year of Publication 23.08.2018
Patent
브루톤 티로신 키나제의 억제제로서의 폴리사이클릭 화합물
CHEN WEI, XIAO KUN, TICHENOR MARK S, ARORA NIDHI, ZHANG FEIHUANG, WEI JIANMEI, KREUTTER KEVIN, WIENER JOHN J. M, EDWARDS JAMES P, BACANI GENESIS M, CAI MIN, DECKHUT CHARLOTTE POOLEY, VENABLE JENNIFER D, ZHU YAOPING, BEMBENEK SCOTT D, GHOSH BRAHMANANDA, WU YAO, BARBAY JOSEPH KENT, LI GANG
Year of Publication 22.08.2018
Get full text
Year of Publication 22.08.2018
Patent