Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
Worthmann, Anna, John, Clara, Rühlemann, Malte C, Baguhl, Miriam, Heinsen, Femke-Anouska, Schaltenberg, Nicola, Heine, Markus, Schlein, Christian, Evangelakos, Ioannis, Mineo, Chieko, Fischer, Markus, Dandri, Maura, Kremoser, Claus, Scheja, Ludger, Franke, Andre, Shaul, Philip W, Heeren, Joerg
Published in Nature medicine (01.07.2017)
Published in Nature medicine (01.07.2017)
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Journal Article
FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model
Deuschle, Ulrich, Schüler, Julia, Schulz, Andreas, Schlüter, Thomas, Kinzel, Olaf, Abel, Ulrich, Kremoser, Claus
Published in PloS one (09.10.2012)
Published in PloS one (09.10.2012)
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Journal Article
Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice
Hambruch, Eva, Miyazaki-Anzai, Shinobu, Hahn, Ulrike, Matysik, Silke, Boettcher, Alfred, Perović-Ottstadt, Sanja, Schlüter, Thomas, Kinzel, Olaf, Krol, Helen Desiree, Deuschle, Ulrich, Burnet, Michael, Levi, Moshe, Schmitz, Gerd, Miyazaki, Makoto, Kremoser, Claus
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2012)
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Journal Article
The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model
Schwabl, Philipp, Hambruch, Eva, Budas, Grant R, Supper, Paul, Burnet, Michael, Liles, John T, Birkel, Manfred, Brusilovskaya, Ksenia, Königshofer, Philipp, Peck-Radosavljevic, Markus, Watkins, William J, Trauner, Michael, Breckenridge, David G, Kremoser, Claus, Reiberger, Thomas
Published in Biomedicines (09.01.2021)
Published in Biomedicines (09.01.2021)
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Journal Article
Free Deoxycholic Acid Exacerbates Vascular Calcification in CKD through ER Stress-Mediated ATF4 Activation
Miyazaki-Anzai, Shinobu, Masuda, Masashi, Shiozaki, Yuji, Keenan, Audrey L, Chonchol, Michel, Kremoser, Claus, Miyazaki, Makoto
Published in Kidney360 (01.05.2021)
Published in Kidney360 (01.05.2021)
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Journal Article
The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine‐rich glycoprotein
Deuschle, Ulrich, Birkel, Manfred, Hambruch, Eva, Hornberger, Martin, Kinzel, Olaf, Perović‐Ottstadt, Sanja, Schulz, Andreas, Hahn, Ulrike, Burnet, Michael, Kremoser, Claus
Published in International journal of cancer (01.06.2015)
Published in International journal of cancer (01.06.2015)
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Journal Article
In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases
Drescher, Uwe, Kremoser, Claus, Handwerker, Claudia, Löschinger, Jürgen, Noda, Masaharu, Bonhoeffer, Friedrich
Published in Cell (11.08.1995)
Published in Cell (11.08.1995)
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Journal Article
Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol
Otte, Kerstin, Kranz, Harald, Kober, Ingo, Thompson, Paul, Hoefer, Michael, Haubold, Bernhard, Remmel, Bettina, Voss, Hartmut, Kaiser, Carmen, Albers, Michael, Cheruvallath, Zaccharias, Jackson, David, Casari, Georg, Koegl, Manfred, Pääbo, Svante, Mous, Jan, Kremoser, Claus, Deuschle, Ulrich
Published in Molecular and Cellular Biology (01.02.2003)
Published in Molecular and Cellular Biology (01.02.2003)
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Journal Article
Nonsteroidal FXR Ligands: Current Status and Clinical Applications
Gege, Christian, Hambruch, Eva, Hambruch, Nina, Kinzel, Olaf, Kremoser, Claus
Published in Handbook of experimental pharmacology (01.01.2019)
Published in Handbook of experimental pharmacology (01.01.2019)
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Journal Article
A Novel Principle for Partial Agonism of Liver X Receptor Ligands
Albers, Michael, Blume, Beatrix, Schlueter, Thomas, Wright, Matthew B., Kober, Ingo, Kremoser, Claus, Deuschle, Ulrich, Koegl, Manfred
Published in The Journal of biological chemistry (24.02.2006)
Published in The Journal of biological chemistry (24.02.2006)
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Journal Article
Knocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities
Gege, Christian, Kinzel, Olaf, Steeneck, Christoph, Schulz, Andreas, Kremoser, Claus
Published in Current topics in medicinal chemistry (2014)
Published in Current topics in medicinal chemistry (2014)
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Journal Article
The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction
Schwabl, Philipp, Hambruch, Eva, Seeland, Berit A, Hayden, Hubert, Wagner, Michael, Garnys, Lukas, Strobel, Bastian, Schubert, Tim-Lukas, Riedl, Florian, Mitteregger, Dieter, Burnet, Michael, Starlinger, Patrick, Oberhuber, Georg, Deuschle, Ulrich, Rohr-Udilova, Nataliya, Podesser, Bruno K, Peck-Radosavljevic, Markus, Reiberger, Thomas, Kremoser, Claus, Trauner, Michael
Published in Journal of hepatology (01.04.2017)
Published in Journal of hepatology (01.04.2017)
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Journal Article
Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice
de Boer, Jan Freark, Schonewille, Marleen, Boesjes, Marije, Wolters, Henk, Bloks, Vincent W, Bos, Trijnie, van Dijk, Theo H, Jurdzinski, Angelika, Boverhof, Renze, Wolters, Justina C, Kuivenhoven, Jan A, van Deursen, Jan M, Oude Elferink, Ronald P.J, Moschetta, Antonio, Kremoser, Claus, Verkade, Henkjan J, Kuipers, Folkert, Groen, Albert K
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
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Journal Article
PS-133-LXR inverse agonists reduce steatosis and fibrosis in the STAM mouse model but also improve insulin sensitivity in a high fat diet mouse clamp study
Hambruch, Eva, Gege, Christian, Kinzel, Olaf, Hauser, Katharina, Birkel, Manfred, Deuschle, Ulrich, Kremoser, Claus
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
Development of Cilofexor, an intestinally-biased Farnesoid X Receptor agonist, for the treatment of fatty liver disease
Hollenback, David, Hambruch, Eva, Fink, Gero, Birkel, Manfred, Schulz, Andreas, Hornberger, Martin, Liu, Kathy, Staiger, Kelly MacLennan, Krol, Helen Desiree, Deuschle, Ulrich, Steeneck, Christoph, Kinzel, Olaf, Liles, John T, Budas, Grant, Watkins, William J, Kremoser, Claus
Published in The Journal of pharmacology and experimental therapeutics (26.02.2024)
Published in The Journal of pharmacology and experimental therapeutics (26.02.2024)
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Journal Article
Dietary α-tocopherol and atorvastatin reduce high-fat-induced lipid accumulation and down-regulate CD36 protein in the liver of guinea pigs
Podszun, Maren C., Grebenstein, Nadine, Spruss, Astrid, Schlueter, Thomas, Kremoser, Claus, Bergheim, Ina, Frank, Jan
Published in The Journal of nutritional biochemistry (01.05.2014)
Published in The Journal of nutritional biochemistry (01.05.2014)
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Journal Article
Abstract 1210: Targeting the IDO1-Kynurenine-AhR pathway for cancer immunotherapy
Pinto, Sheena, Steeneck, Christoph, Albers, Michael, Anderhub, Simon, Birkel, Manfred, Buselic-Wölfel, Larisa, Eisenhardt, Gisela, Kremoser, Claus, Hoffmann, Thomas, Deuschle, Ulrich
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
FRI-303-How to develop a differentiated FXR agonist: GS-9674 shows a reduced side effect profile in mice, monkeys amd human phase 1 studies compared to its predecessor Px-102
Hambruch, Eva, Hollenback, David, Liles, John, Kinzel, Olaf, Birkel, Manfred, Fink, Gero, French, Dorothy, Gege, Christian, Hornberger, Martin, Watkins, William, Kremoser, Claus
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
Abstract 3588: Identification of a potent, orally bioavailable and selective MCT4 Inhibitor for the treatment of solid Warburg tumors
Hambruch, Nina, Herkert, Barbara, Gege, Christian, Mallinger, Aurelie, Fabian, Johannes, Kinzel, Olaf, Wang, Yansong, Fink, Gero, Albers, Michael, Funk, Anette, Bittman-Waetzig, Annika, Fleckenstein, Tilly, Braun, Floriane, Kremoser, Claus
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article