Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation
Schlegelmilch, Karin, Mohseni, Morvarid, Kirak, Oktay, Pruszak, Jan, Rodriguez, J. Renato, Zhou, Dawang, Kreger, Bridget T., Vasioukhin, Valera, Avruch, Joseph, Brummelkamp, Thijn R., Camargo, Fernando D.
Published in Cell (04.03.2011)
Published in Cell (04.03.2011)
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Journal Article
α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1
Silvis, Mark R, Kreger, Bridget T, Lien, Wen-Hui, Klezovitch, Olga, Rudakova, G Marianna, Camargo, Fernando D, Lantz, Dan M, Seykora, John T, Vasioukhin, Valeri
Published in Science signaling (24.05.2011)
Published in Science signaling (24.05.2011)
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Journal Article
Micro RNA responses to chronic or acute exposures to low dose ionizing radiation
Chaudhry, M. Ahmad, Omaruddin, Romaica A., Kreger, Bridget, de Toledo, Sonia M., Azzam, Edouard I.
Published in Molecular biology reports (01.07.2012)
Published in Molecular biology reports (01.07.2012)
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Journal Article
Abstract 1658: CFT1946, a potent, selective BRAF V600X mutant-specific degrader demonstrates superior activity as a single agent to clinically approved BRAF inhibitors and standard of care combinations in preclinical models of BRAF V600X melanoma, CRC, NSCLC, and brain metastasis
Kreger, Bridget, Stephenson, Jacob R., Sowa, Mathew E., Perino, Samantha A., Poling, Laura L., Hurh, Eunju, Thomenius, Michael J., Liang, Yanke, Fisher, Stewart L., Pollock, Roy M.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract ND05: The discovery and characterization of CFT1946: A potent, selective, and orally bioavailable degrader of mutant BRAF for the treatment of BRAF-driven cancers
Liang, Yanke, Sowa, Mathew E., Jackson, Katrina L., Simard, Jeffrey R., Kreger, Bridget, Li, Ping, Poling, Laura, Baddour, Joelle, Good, Andrew, Huang, Hongwei, Eron, Scott, Nasveschuk, Christopher G., Yu, Robert, Fitzgerald, Mark, Garza, Victoria, O’Shea, Morgan W., Veits, Gesine, Yap, Jeremy L., Moustakim, Moses, Hart, Ashley, Agafonov, Roman V., Sarkissian, Grace, Patel, Joe S., Deibler, Richard, Cole, Kyle S., Cocozziello, David, Rahman, Fazlur, Phillips, Andrew J., Norton, Elizabeth, Crystal, Adam S., Pollock, Roy M., Fisher, Stewart L.
Published in Cancer research (Chicago, Ill.) (29.05.2023)
Published in Cancer research (Chicago, Ill.) (29.05.2023)
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Abstract 3425: The discovery and characterization of CFT1946: A potent, selective, and orally bioavailable degrader of mutant BRAF for the treatment of BRAF-driven cancers
Liang, Yanke, Sowa, Mathew E., Jackson, Katrina L., Simard, Jeffrey R., Kreger, Bridget, Li, Ping, Poling, Laura, Baddour, Joelle, Good, Andrew, Huang, Hongwei, Eron, Scott, Nasveschuk, Christopher G., Yu, Robert, Fitzgerald, Mark, Garza, Victoria, O’Shea, Morgan W., Veits, Gesine, Yap, Jeremy Y., Moustakim, Moses, Hart, Ashley, Agafonov, Roman V., Sarkissian, Grace, Patel, Joe S., Deibler, Richard, Cole, Kyle S., Cocozziello, David, Rahman, Fazlur, Phillips, Andrew J., Norton, Elizabeth, Crystal, Adam S., Pollock, Roy M., Fisher, Stewart L.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 2158: Preclinical evaluation of CFT1946 as a selective degrader of mutant BRAF for the treatment of BRAF driven cancers
Sowa, Mathew E., Kreger, Bridget, Baddour, Joelle, Liang, Yanke, Simard, Jeffrey R., Poling, Laura, Li, Ping, Yu, Robert, Hart, Ashley, Agafonov, Roman V., Sarkissian, Grace, Patel, Joe Sahil, Deibler, Richard, Cole, Kyle S., Eron, Scott, Cocozziello, David, Rahman, Fazlur, Moustakim, Moses, Nasveschuk, Christopher G., Jackson, Katrina L., Fitzgerald, Mark, Garza, Victoria, O’Shea, Morgan, Veits, Gesine, Yap, Jeremy L., Phillips, Andrew J., Norton, Elizabeth, Crystal, Adam S., Fisher, Stewart L., Pollock, Roy M.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
MORPHIC FORMS OF A MUTANT BRAF DEGRADER AND METHODS OF MANUFACTURE THEREOF
KREGER, Bridget, LI, Meiqi, SCHNADERBECK, Matthew, HE, Minsheng, JIANG, Siyi, LU, Jiannan, POLLOCK, Roy, CHEN, Bolu, YU, Robert
Year of Publication 04.07.2024
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Year of Publication 04.07.2024
Patent
MORPHIC FORMS OF A MUTANT BRAF DEGRADER AND METHODS OF MANUFACTURE THEREOF
KREGER, Bridget, LI, Meiqi, SCHNADERBECK, Matthew, HE, Minsheng, JIANG, Siyi, LU, Jiannan, POLLOCK, Roy, CHEN, Bolu, YU, Robert
Year of Publication 06.06.2024
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Year of Publication 06.06.2024
Patent