Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation
Wlodarska, Marta, Luo, Chengwei, Kolde, Raivo, d’Hennezel, Eva, Annand, John W., Heim, Cortney E., Krastel, Philipp, Schmitt, Esther K., Omar, Abdifatah S., Creasey, Elizabeth A., Garner, Ashley L., Mohammadi, Sina, O’Connell, Daniel J., Abubucker, Sahar, Arthur, Timothy D., Franzosa, Eric A., Huttenhower, Curtis, Murphy, Leon O., Haiser, Henry J., Vlamakis, Hera, Porter, Jeffrey A., Xavier, Ramnik J.
Published in Cell host & microbe (12.07.2017)
Published in Cell host & microbe (12.07.2017)
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Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation
Carson, Cheryl, Raman, Pichai, Tullai, Jennifer, Xu, Lei, Henault, Martin, Thomas, Emily, Yeola, Sarita, Lao, Jianmin, McPate, Mark, Verkuyl, J Martin, Marsh, George, Sarber, Jason, Amaral, Adam, Bailey, Scott, Lubicka, Danuta, Pham, Helen, Miranda, Nicolette, Ding, Jian, Tang, Hai-Ming, Ju, Haisong, Tranter, Pamela, Ji, Nan, Krastel, Philipp, Jain, Rishi K, Schumacher, Andrew M, Loureiro, Joseph J, George, Elizabeth, Berellini, Giuliano, Ross, Nathan T, Bushell, Simon M, Erdemli, Gül, Solomon, Jonathan M
Published in PloS one (22.06.2015)
Published in PloS one (22.06.2015)
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The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease
Schmitt, Esther K., Riwanto, Meliana, Sambandamurthy, Vasan, Roggo, Silvio, Miault, Charlotte, Zwingelstein, Christian, Krastel, Philipp, Noble, Christian, Beer, David, Rao, Srinivasa P. S., Au, Melvin, Niyomrattanakit, Pornwaratt, Lim, Viviam, Zheng, Jun, Jeffery, Douglas, Pethe, Kevin, Camacho, Luis R.
Published in Angewandte Chemie (International ed.) (20.06.2011)
Published in Angewandte Chemie (International ed.) (20.06.2011)
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High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions
Hoepfner, Dominic, Helliwell, Stephen B., Sadlish, Heather, Schuierer, Sven, Filipuzzi, Ireos, Brachat, Sophie, Bhullar, Bhupinder, Plikat, Uwe, Abraham, Yann, Altorfer, Marc, Aust, Thomas, Baeriswyl, Lukas, Cerino, Raffaele, Chang, Lena, Estoppey, David, Eichenberger, Juerg, Frederiksen, Mathias, Hartmann, Nicole, Hohendahl, Annika, Knapp, Britta, Krastel, Philipp, Melin, Nicolas, Nigsch, Florian, Oakeley, Edward J., Petitjean, Virginie, Petersen, Frank, Riedl, Ralph, Schmitt, Esther K., Staedtler, Frank, Studer, Christian, Tallarico, John A., Wetzel, Stefan, Fishman, Mark C., Porter, Jeffrey A., Movva, N. Rao
Published in Microbiological research (01.02.2014)
Published in Microbiological research (01.02.2014)
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Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu
Morris, Rowan P, Leeds, Jennifer A, Naegeli, Hans Ulrich, Oberer, Lukas, Memmert, Klaus, Weber, Eric, LaMarche, Matthew J, Parker, Christian N, Burrer, Nathalie, Esterow, Stacey, Hein, Andreas E, Schmitt, Esther K, Krastel, Philipp
Published in Journal of the American Chemical Society (29.04.2009)
Published in Journal of the American Chemical Society (29.04.2009)
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Journal Article
Natural products as catalysts for innovation: a pharmaceutical industry perspective
Schmitt, Esther K, Moore, Charles M, Krastel, Philipp, Petersen, Frank
Published in Current opinion in chemical biology (01.08.2011)
Published in Current opinion in chemical biology (01.08.2011)
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Journal Article
Deliberations on Natural Products and Future Directions in the Pharmaceutical Industry
Buntin, Kathrin, Ertl, Peter, Hoepfner, Dominic, Krastel, Philipp, Oakeley, Edward J., Pistorius, Dominik, Schuhmann, Tim, Wong, Joanne, Petersen, Frank
Published in Chimia (25.08.2021)
Published in Chimia (25.08.2021)
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Antibacterial and Solubility Optimization of Thiomuracin A
LaMarche, Matthew J, Leeds, Jennifer A, Brewer, Jason, Dean, Karl, Ding, Jian, Dzink-Fox, Joanne, Gamber, Gabe, Jain, Akash, Kerrigan, Ryan, Krastel, Philipp, Lee, Kwangho, Lombardo, Franco, McKenney, David, Neckermann, Georg, Osborne, Colin, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Robinson, Zachary, Schmitt, Esther, Stams, Travis, Tiamfook, Stacey, Yu, Donghui, Whitehead, Lewis
Published in Journal of medicinal chemistry (28.07.2016)
Published in Journal of medicinal chemistry (28.07.2016)
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Identification of elongation factor G as the conserved cellular target of argyrin B
Nyfeler, Beat, Hoepfner, Dominic, Palestrant, Deborah, Kirby, Christina A, Whitehead, Lewis, Yu, Robert, Deng, Gejing, Caughlan, Ruth E, Woods, Angela L, Jones, Adriana K, Barnes, S Whitney, Walker, John R, Gaulis, Swann, Hauy, Ervan, Brachmann, Saskia M, Krastel, Philipp, Studer, Christian, Riedl, Ralph, Estoppey, David, Aust, Thomas, Movva, N Rao, Wang, Zuncai, Salcius, Michael, Michaud, Gregory A, McAllister, Gregory, Murphy, Leon O, Tallarico, John A, Wilson, Christopher J, Dean, Charles R
Published in PloS one (10.09.2012)
Published in PloS one (10.09.2012)
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Decatransin, a novel natural product inhibiting protein translocation at the Sec61/SecY translocon
Junne, Tina, Wong, Joanne, Studer, Christian, Aust, Thomas, Bauer, Benedikt W., Beibel, Martin, Bhullar, Bhupinder, Bruccoleri, Robert, Eichenberger, Jürg, Estoppey, David, Hartmann, Nicole, Knapp, Britta, Krastel, Philipp, Melin, Nicolas, Oakeley, Edward J., Oberer, Lukas, Riedl, Ralph, Roma, Guglielmo, Schuierer, Sven, Petersen, Frank, Tallarico, John A., Rapoport, Tom A., Spiess, Martin, Hoepfner, Dominic
Published in Journal of cell science (01.01.2015)
Published in Journal of cell science (01.01.2015)
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Endophenazines A-D, New Phenazine Antibiotics from the Arthropod Associated Endosymbiont Streptomyces anulatus: I. Taxonomy, Fermentation, Isolation and Biological Activities
GEBHARDT, KLAUS, SCHIMANA, JUDITH, KRASTEL, PHILIPP, DETTNER, KONRAD, RHEINHEIMER, JOACHIM, ZEECK, AXEL, FIEDLER, HANS-PETER
Published in Journal of antibiotics (01.09.2002)
Published in Journal of antibiotics (01.09.2002)
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Endophenazines A-D, New Phenazine Antibiotics from the Athropod Associated Endosymbiont Streptomyces anulatus: II. Structure Elucidation
KRASTEL, PHILIPP, ZEECK, AXEL, GEBHARDT, KLAUS, FIEDLER, HANS-PETER, RHEINHEIMER, JOACHIM
Published in Journal of antibiotics (01.09.2002)
Published in Journal of antibiotics (01.09.2002)
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Scaling up for success: from bioactive natural products to new medicines
Helf, Maximilian J., Buntin, Kathrin, Klančar, Andrej, Rust, Michael, Petersen, Frank, Pistorius, Dominik, Weber, Eric, Wong, Joanne, Krastel, Philipp
Published in Natural product reports (12.08.2024)
Published in Natural product reports (12.08.2024)
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Evolution of Novartis’ Small Molecule Screening Deck Design
Schuffenhauer, Ansgar, Schneider, Nadine, Hintermann, Samuel, Auld, Douglas, Blank, Jutta, Cotesta, Simona, Engeloch, Caroline, Fechner, Nikolas, Gaul, Christoph, Giovannoni, Jerome, Jansen, Johanna, Joslin, John, Krastel, Philipp, Lounkine, Eugen, Manchester, John, Monovich, Lauren G, Pelliccioli, Anna Paola, Schwarze, Manuel, Shultz, Michael D, Stiefl, Nikolaus, Baeschlin, Daniel K
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Generation of Bioactivity‐Tailored FK506/FK520 Analogs by CRISPR Editing in Streptomyces tsukubaensis
Buntin, Kathrin, Mrak, Peter, Pivk Lukančič, Petra, Wollbrett, Séverine, Drčar, Tjasa, Krastel, Philipp, Thibaut, Christian, Salcius, Michael, Gao, Xiaolin, Wang, Shaowen, Weber, Eric, Koplan, Eva, Regenass, Hugo
Published in Chemistry : a European journal (11.01.2024)
Published in Chemistry : a European journal (11.01.2024)
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Dark chemical matter as a promising starting point for drug lead discovery
Wassermann, Anne Mai, Lounkine, Eugen, Hoepfner, Dominic, Le Goff, Gaelle, King, Frederick J, Studer, Christian, Peltier, John M, Grippo, Melissa L, Prindle, Vivian, Tao, Jianshi, Schuffenhauer, Ansgar, Wallace, Iain M, Chen, Shanni, Krastel, Philipp, Cobos-Correa, Amanda, Parker, Christian N, Davies, John W, Glick, Meir
Published in Nature chemical biology (01.12.2015)
Published in Nature chemical biology (01.12.2015)
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Journal Article
Discovery of the actinoplanic acid pathway in Streptomyces rapamycinicus reveals a genetically conserved synergism with rapamycin
Mrak, Peter, Krastel, Philipp, Pivk Lukančič, Petra, Tao, Jianshi, Pistorius, Dominik, Moore, Charles M.
Published in The Journal of biological chemistry (28.12.2018)
Published in The Journal of biological chemistry (28.12.2018)
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Journal Article
Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties
Krastel, Philipp, Roggo, Silvio, Schirle, Markus, Ross, Nathan T., Perruccio, Francesca, Aspesi Jr, Peter, Aust, Thomas, Buntin, Kathrin, Estoppey, David, Liechty, Brigitta, Mapa, Felipa, Memmert, Klaus, Miller, Howard, Pan, Xuewen, Riedl, Ralph, Thibaut, Christian, Thomas, Jason, Wagner, Trixie, Weber, Eric, Xie, Xiaobing, Schmitt, Esther K., Hoepfner, Dominic
Published in Angewandte Chemie (International ed.) (24.08.2015)
Published in Angewandte Chemie (International ed.) (24.08.2015)
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Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria
Yeung, Bryan K. S, Zou, Bin, Rottmann, Matthias, Lakshminarayana, Suresh B, Ang, Shi Hua, Leong, Seh Yong, Tan, Jocelyn, Wong, Josephine, Keller-Maerki, Sonja, Fischli, Christoph, Goh, Anne, Schmitt, Esther K, Krastel, Philipp, Francotte, Eric, Kuhen, Kelli, Plouffe, David, Henson, Kerstin, Wagner, Trixie, Winzeler, Elizabeth A, Petersen, Frank, Brun, Reto, Dartois, Veronique, Diagana, Thierry T, Keller, Thomas H
Published in Journal of medicinal chemistry (22.07.2010)
Published in Journal of medicinal chemistry (22.07.2010)
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