Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMSElectronic supplementary information (ESI) available: Chemical structures of prominent thiosemicarbazones; NMR data of the metabolite M1; phase II metabolism; HRMS spectra of iron complexation for Triapine and M1; cytotoxicity of Triapine and M1 in Triapine-resistant cancer cell lines. See DOI: 10.1039/c7an00902j
Pelivan, Karla, Frensemeier, Lisa, Karst, Uwe, Koellensperger, Gunda, Bielec, Bjoern, Hager, Sonja, Heffeter, Petra, Keppler, Bernhard K, Kowol, Christian R
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A comparative study of a-N-pyridyl thiosemicarbazones: Spectroscopic properties, solution stability and copper(II) complexation
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Published in Inorganica Chimica Acta (01.03.2018)
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Abstract 2230: Entinostat potentiates chemotherapeutic efficacy in small cell lung cancer cells
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Abstract 4905: Anticancer activity and paraptosis induction of novel bipyridine-silver(I) compounds against resistant colorectal and ovarian cancer cell lines
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Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Comparative Solution Equilibrium Study of the Interactions of Copper(II), Iron(II) and Zinc(II) with Triapine (3-Aminopyridine-2-carbaldehyde Thiosemicarbazone) and Related Ligands
Enyedy, Éva A., Nagy, Nóra V., Zsigó, Éva, Kowol, Christian R., Arion, Vladimir B., Keppler, Bernhard K., Kiss, Tamás
Published in European Journal of Inorganic Chemistry (01.04.2010)
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Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexesElectronic supplementary information (ESI) available. CCDC 1451694-1451696. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6dt00648e
Terenzi, Alessio, Lötsch, Daniela, van Schoonhoven, Sushilla, Roller, Alexander, Kowol, Christian R, Berger, Walter, Keppler, Bernhard K, Barone, Giampaolo
Year of Publication 04.05.2016
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Another step toward DNA selective targeting: Ni super(II) and Cu super(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes
Terenzi, Alessio, Lotsch, Daniela, van Schoonhoven, Sushilla, Roller, Alexander, Kowol, Christian R, Berger, Walter, Keppler, Bernhard K, Barone, Giampaolo
Published in Dalton transactions : an international journal of inorganic chemistry (01.05.2016)
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Another step toward DNA selective targeting: NiII and CuII complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes† †Electronic supplementary information (ESI) available. CCDC 1451694–1451696. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6dt00648e Click here for additional data file. Click here for additional data file
Terenzi, Alessio, Lötsch, Daniela, van Schoonhoven, Sushilla, Roller, Alexander, Kowol, Christian R., Berger, Walter, Keppler, Bernhard K., Barone, Giampaolo
Published in Dalton transactions : an international journal of inorganic chemistry (04.04.2016)
Published in Dalton transactions : an international journal of inorganic chemistry (04.04.2016)
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Abstract 4397: Preclinical development of a novel hypoxia-activated EGFR inhibitor using a cobalt(III)-based prodrug design
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Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Impact of Stepwise NH 2 -Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention
Kowol, Christian R., Miklos, Walter, Pfaff, Sarah, Hager, Sonja, Kallus, Sebastian, Pelivan, Karla, Kubanik, Mario, Enyedy, Éva A., Berger, Walter, Heffeter, Petra, Keppler, Bernhard K.
Published in Journal of medicinal chemistry (28.07.2016)
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An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivoElectronic supplementary information (ESI) available: Experimental materials and methods, characterization details of all compounds, X-ray crystal structures. CCDC 1499561 and 1499562. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03862j
Mayr, Josef, Heffeter, Petra, Groza, Diana, Galvez, Luis, Koellensperger, Gunda, Roller, Alexander, Alte, Beatrix, Haider, Melanie, Berger, Walter, Kowol, Christian R, Keppler, Bernhard K
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An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo † †Electronic supplementary information (ESI) available: Experimental materials and methods, characterization details of all compounds, X-ray crystal structures. CCDC 1499561 and 1499562. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03862j Click here for additional data file. Click here for additional data file
Mayr, Josef, Heffeter, Petra, Groza, Diana, Galvez, Luis, Koellensperger, Gunda, Roller, Alexander, Alte, Beatrix, Haider, Melanie, Berger, Walter, Kowol, Christian R., Keppler, Bernhard K.
Published in Chemical science (Cambridge) (15.12.2016)
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Abstract 5461: Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance
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Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Preclinical characterization of anticancer gallium(III) complexes: Solubility, stability, lipophilicity and binding to serum proteins
Rudnev, Alexander V., Foteeva, Lidia S., Kowol, Christian, Berger, Roland, Jakupec, Michael A., Arion, Vladimir B., Timerbaev, Andrei R., Keppler, Bernhard K.
Published in Journal of inorganic biochemistry (01.11.2006)
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Zweifel an einem Dogma: Hydrolyse äquatorialer Liganden von Pt IV ‐Komplexen unter physiologischen Bedingungen
Kastner, Alexander, Poetsch, Isabella, Mayr, Josef, Burda, Jaroslav V., Roller, Alexander, Heffeter, Petra, Keppler, Bernhard K., Kowol, Christian R.
Published in Angewandte Chemie (27.05.2019)
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Hydroxy and ether functionalized dithiolanes: Models for the active site of the [FeFe] hydrogenase
Apfel, Ulf-Peter, Kowol, Christian R., Kloss, Florian, Görls, Helmar, Keppler, Bernhard K., Weigand, Wolfgang
Published in Journal of organometallic chemistry (01.03.2011)
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Pichler, Verena, Mayr, Josef, Heffeter, Petra, Dömötör, Orsolya, Enyedy, Éva A, Hermann, Gerrit, Groza, Diana, Köllensperger, Gunda, Galanksi, Markus, Berger, Walter, Keppler, Bernhard K, Kowol, Christian R
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Complex‐Formation Ability of Salicylaldehyde Thiosemicarbazone towards Zn II , Cu II , Fe II , Fe III and Ga III Ions
Enyedy, Éva A., Zsigó, Éva, Nagy, Nóra V., Kowol, Christian R., Roller, Alexander, Keppler, Bernhard K., Kiss, Tamás
Published in European journal of inorganic chemistry (01.09.2012)
Published in European journal of inorganic chemistry (01.09.2012)
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