IMGN779, a Novel CD33-Targeting Antibody-Drug Conjugate with DNA-Alkylating Activity, Exhibits Potent Antitumor Activity in Models of AML
Kovtun, Yelena, Noordhuis, Paul, Whiteman, Kathleen R, Watkins, Krystal, Jones, Gregory E, Harvey, Lauren, Lai, Katharine C, Portwood, Scott, Adams, Sharlene, Sloss, Callum M, Schuurhuis, Gerrit Jan, Ossenkoppele, Gert, Wang, Eunice S, Pinkas, Jan
Published in Molecular cancer therapeutics (01.06.2018)
Published in Molecular cancer therapeutics (01.06.2018)
Get full text
Journal Article
Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance
KOVTUN, Yelena V, AUDETTE, Charlene A, LAI, Katharine C, WIDDISON, Wayne C, KELLOGG, Brenda, JOHNSON, Holly, PINKAS, Jan, LUTZ, Robert J, SINGH, Rajeeva, GOLDMACHER, Victor S, CHARI, Ravi V. J, MAYO, Michele F, JONES, Gregory E, DOHERTY, Heather, MALONEY, Erin K, ERICKSON, Hans K, XIUXIA SUN, WILHELM, Sharon, AB, Olga
Published in Cancer research (Chicago, Ill.) (15.03.2010)
Published in Cancer research (Chicago, Ill.) (15.03.2010)
Get full text
Journal Article
Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
ERICKSON, Hans K, PARK, Peter U, WIDDISON, Wayne C, KOVTUN, Yelena V, GARRETT, Lisa M, HOFFMAN, Karen, LUTZ, Robert J, GOLDMACHER, Victor S, BLÄTTLER, Walter A
Published in Cancer research (Chicago, Ill.) (15.04.2006)
Published in Cancer research (Chicago, Ill.) (15.04.2006)
Get full text
Journal Article
Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability
Oroudjev, Emin, Lopus, Manu, Wilson, Leslie, Audette, Charlene, Provenzano, Carmela, Erickson, Hans, Kovtun, Yelena, Chari, Ravi, Jordan, Mary Ann
Published in Molecular cancer therapeutics (01.10.2010)
Published in Molecular cancer therapeutics (01.10.2010)
Get full text
Journal Article
CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia
Angelova, Evgeniya, Audette, Charlene, Kovtun, Yelena, Daver, Naval, Wang, Sa A, Pierce, Sherry, Konoplev, Sergej N, Khogeer, Haitham, Jorgensen, Jeffrey L, Konopleva, Marina, Zweidler-McKay, Patrick A, Medeiros, L Jeffrey, Kantarjian, Hagop M, Jabbour, Elias J, Khoury, Joseph D
Published in Haematologica (Roma) (01.04.2019)
Published in Haematologica (Roma) (01.04.2019)
Get full text
Journal Article
A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells
Kovtun, Yelena, Jones, Gregory E., Adams, Sharlene, Harvey, Lauren, Audette, Charlene A., Wilhelm, Alan, Bai, Chen, Rui, Lingyun, Laleau, Rassol, Liu, Fenghua, Ab, Olga, Setiady, Yulius, Yoder, Nicholas C., Goldmacher, Victor S., Chari, Ravi V.J., Pinkas, Jan, Chittenden, Thomas
Published in Blood advances (24.04.2018)
Published in Blood advances (24.04.2018)
Get full text
Journal Article
Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates
Zhao, Robert Y, Wilhelm, Sharon D, Audette, Charlene, Jones, Gregory, Leece, Barbara A, Lazar, Alexandru C, Goldmacher, Victor S, Singh, Rajeeva, Kovtun, Yelena, Widdison, Wayne C, Lambert, John M, Chari, Ravi V. J
Published in Journal of medicinal chemistry (26.05.2011)
Published in Journal of medicinal chemistry (26.05.2011)
Get full text
Journal Article
Disulfide-Linked Antibody−Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage
Kellogg, Brenda A, Garrett, Lisa, Kovtun, Yelena, Lai, Katharine C, Leece, Barbara, Miller, Michael, Payne, Gillian, Steeves, Rita, Whiteman, Kathleen R, Widdison, Wayne, Xie, Hongsheng, Singh, Rajeeva, Chari, Ravi V. J, Lambert, John M, Lutz, Robert J
Published in Bioconjugate chemistry (20.04.2011)
Published in Bioconjugate chemistry (20.04.2011)
Get full text
Journal Article
A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs)
Miller, Michael L, Shizuka, Manami, Wilhelm, Alan, Salomon, Paulin, Reid, Emily E, Lanieri, Leanne, Sikka, Surina, Maloney, Erin K, Harvey, Lauren, Qiu, Qifeng, Archer, Katie E, Bai, Chen, Vitharana, Dilrukshi, Harris, Luke, Singh, Rajeeva, Ponte, Jose F, Yoder, Nicholas C, Kovtun, Yelena, Lai, Katharine C, Ab, Olga, Pinkas, Jan, Keating, Thomas A, Chari, Ravi V J
Published in Molecular cancer therapeutics (01.03.2018)
Published in Molecular cancer therapeutics (01.03.2018)
Get full text
Journal Article
Functional Analysis of Oxidative Stress-Activated Mitogen-Activated Protein Kinase Cascade in Plants
Kovtun, Y, Chiu, W L, Tena, G, Sheen, J
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (14.03.2000)
Get full text
Journal Article
Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen
KOVTUN, Yelena V, AUDETTE, Charlene A, YUMEI YE, HONGSHENG XIE, RUBERTI, Mary F, PHINNEY, Sara J, LEECE, Barbara A, CHITTENDEN, Thomas, BLÄTTLER, Walter A, GOLDMACHER, Victor S
Published in Cancer research (Chicago, Ill.) (15.03.2006)
Published in Cancer research (Chicago, Ill.) (15.03.2006)
Get full text
Journal Article
A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells
Singh, Rajeeva, Setiady, Yulius Y, Ponte, Jose, Kovtun, Yelena V, Lai, Katharine C, Hong, E Erica, Fishkin, Nathan, Dong, Ling, Jones, Gregory E, Coccia, Jennifer A, Lanieri, Leanne, Veale, Karen, Costoplus, Juliet A, Skaletskaya, Anna, Gabriel, Rabih, Salomon, Paulin, Wu, Rui, Qiu, Qifeng, Erickson, Hans K, Lambert, John M, Chari, Ravi V J, Widdison, Wayne C
Published in Molecular cancer therapeutics (01.06.2016)
Published in Molecular cancer therapeutics (01.06.2016)
Get full text
Journal Article
Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing
Costoplus, Juliet A, Veale, Karen H, Qiu, Qifeng, Ponte, Jose F, Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Bartle, Laura M, Salomon, Paulin, Wu, Rui, Maloney, Erin K, Kovtun, Yelena V, Ab, Olga, Lai, Kate, Chari, Ravi V. J, Widdison, Wayne C
Published in ACS medicinal chemistry letters (10.10.2019)
Published in ACS medicinal chemistry letters (10.10.2019)
Get full text
Journal Article
Fumonisin B1-Induced Cell Death in Arabidopsis Protoplasts Requires Jasmonate-, Ethylene-, and Salicylate-Dependent Signaling Pathways
Asai, Tsuneaki, Stone, Julie M., Heard, Jacqueline E., Kovtun, Yelena, Yorgey, Peter, Sheen, Jen, Ausubel, Frederick M.
Published in The Plant cell (01.10.2000)
Published in The Plant cell (01.10.2000)
Get full text
Journal Article
Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing
Costoplus, Juliet A., Veale, Karen H., Qiu, Qifeng, Ponte, Jose F., Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Bartle, Laura M., Salomon, Paulin, Wu, Rui, Maloney, Erin K., Kovtun, Yelena V., Ab, Olga, Lai, Kate, Chari, Ravi V. J., Widdison, Wayne C.
Published in ACS medicinal chemistry letters (10.10.2019)
Published in ACS medicinal chemistry letters (10.10.2019)
Get full text
Journal Article
Adapting the Tuning Programme Profiles to the Needs of Russian Higher Education
Karavayeva, Yevgeniya V, Kovtun, Yelena N
Published in Tuning Journal for Higher Education (07.04.2014)
Published in Tuning Journal for Higher Education (07.04.2014)
Get full text
Journal Article