Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
Liu, Longbin, Prime, Michael E, Lee, Matt R, Khetarpal, Vinod, Brown, Christopher J, Johnson, Peter D, Miranda-Azpiazu, Patricia, Chen, Xuemei, Clark-Frew, Daniel, Coe, Samuel, Davis, Randall, Dickie, Anthony, Ebneth, Andreas, Esposito, Simone, Gadouleau, Elise, Gai, Xinjie, Galan, Sebastien, Green, Samantha, Greenaway, Catherine, Giles, Paul, Halldin, Christer, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, Heßmann, Manuela, Jia, Zhisheng, Kiselyov, Alexander, Kotey, Adrian, Krulle, Thomas, Mangette, John E, Marston, Richard W, Menta, Sergio, Mills, Matthew R, Monteagudo, Edith, Nag, Sangram, Nibbio, Martina, Orsatti, Laura, Schaertl, Sabine, Scheich, Christoph, Sproston, Joanne, Stepanov, Vladimir, Svedberg, Marie, Takano, Akihiro, Taylor, Malcolm, Thomas, Wayne, Toth, Miklós, Vaidya, Darshan, Vanräs, Katarina, Weddell, Derek, Wigginton, Ian, Wityak, John, Mrzljak, Ladislav, Munoz-Sanjuan, Ignacio, Bard, Jonathan A, Dominguez, Celia
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates
Liu, Longbin, Johnson, Peter D., Prime, Michael E., Khetarpal, Vinod, Brown, Christopher J., Anzillotti, Luca, Bertoglio, Daniele, Chen, Xuemei, Coe, Samuel, Davis, Randall, Dickie, Anthony P., Esposito, Simone, Gadouleau, Elise, Giles, Paul R., Greenaway, Catherine, Haber, James, Halldin, Christer, Haller, Scott, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, Heßmann, Manuela, Hsai, Ming Min, Khani, Yaser, Kotey, Adrian, Lembo, Angelo, Mangette, John E., Marriner, Gwendolyn A., Marston, Richard W., Mills, Matthew R., Monteagudo, Edith, Forsberg-Morén, Anton, Nag, Sangram, Orsatti, Laura, Sandiego, Christine, Schaertl, Sabine, Sproston, Joanne, Staelens, Steven, Tookey, Jack, Turner, Penelope A., Vecchi, Andrea, Veneziano, Maria, Muñoz-Sanjuan, Ignacio, Bard, Jonathan, Dominguez, Celia
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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[C-11]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins
Liu, Longbin, Johnson, Peter D., Prime, Michael E., Khetarpal, Vinod, Lee, Matthew R., Brown, Christopher J., Chen, Xuemei, Clark-Frew, Daniel, Coe, Samuel, Conlon, Mike, Davis, Randall, Ensor, Samantha, Esposito, Simone, Moren, Anton Forsberg, Gai, Xinjie, Green, Samantha, Greenaway, Catherine, Haber, James, Halldin, Christer, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, He-mann, Manuela, Hsai, Ming Min, Kotey, Adrian, Mangette, John E., Mills, Matthew R., Monteagudo, Edith, Nag, Sangram, Nibbio, Martina, Orsatti, Laura, Schaertl, Sabine, Scheich, Christoph, Sproston, Joanne, Stepanov, Vladimir, Varnas, Katarina, Varrone, Andrea, Wityak, John, Mrzljak, Ladislav, Munoz-Sanjuan, Ignacio, Bard, Jonathan A., Dominguez, Celia
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors
Staben, Steven T, Feng, Jianwen A, Lyle, Karen, Belvin, Marcia, Boggs, Jason, Burch, Jason D, Chua, Ching-ching, Cui, Haifeng, DiPasquale, Antonio G, Friedman, Lori S, Heise, Christopher, Koeppen, Hartmut, Kotey, Adrian, Mintzer, Robert, Oh, Angela, Roberts, David Allen, Rouge, Lionel, Rudolph, Joachim, Tam, Christine, Wang, Weiru, Xiao, Yisong, Young, Amy, Zhang, Yamin, Hoeflich, Klaus P
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)
Takahashi, Hidenori, Riether, Doris, Bartolozzi, Alessandra, Bosanac, Todd, Berger, Valentina, Binetti, Ralph, Broadwater, John, Chen, Zhidong, Crux, Rebecca, De Lombaert, Stéphane, Dave, Rajvee, Dines, Jonathon A, Fadra-Khan, Tazmeen, Flegg, Adam, Garrigou, Michael, Hao, Ming-Hong, Huber, John, Hutzler, J. Matthew, Kerr, Steven, Kotey, Adrian, Liu, Weimin, Lo, Ho Yin, Loke, Pui Leng, Mahaney, Paige E, Morwick, Tina M, Napier, Spencer, Olague, Alan, Pack, Edward, Padyana, Anil K, Thomson, David S, Tye, Heather, Wu, Lifen, Zindell, Renee M, Abeywardane, Asitha, Simpson, Thomas
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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PAD4의 아자-벤즈이미다졸 억제제
KOTEY ADRIAN, GLEAVE LAURA, WIGGINTON IAN, KUMARAVEL GNANASAMBANDAM, LECCI CRISTINA, DEVRAJ RAJESH, TYE HEATHER, KRULLE THOMAS
Year of Publication 04.09.2018
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Year of Publication 04.09.2018
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An orally bioavailable positive allosteric modulator of the mGlu 4 receptor with efficacy in an animal model of motor dysfunction
East, Stephen P., Bamford, Samantha, Dietz, Matthias G.A., Eickmeier, Christian, Flegg, Adam, Ferger, Boris, Gemkow, Mark J., Heilker, Ralf, Hengerer, Bastian, Kotey, Adrian, Loke, Pui, Schänzle, Gerhard, Schubert, Hans-Dieter, Scott, John, Whittaker, Mark, Williams, Mildred, Zawadzki, Przemyslaw, Gerlach, Kai
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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PAD4의 비시클릭 억제제
PARROTT SHELLEY, BROMBRIDGE STEVE, LECCI CRISTINA, LOKE PUI, COOPER SOPHIE, DEVRAJ RAJESH, BOWLES LEE, NORTH CARL, MENICONI MIRCO, PALFREY JORDAN, MONCK NAT, PARKER MICHAEL F, BEAUMONT EDWARD, GADOULEAU ELISE, KOTEY ADRIAN, GLEAVE LAURA, RIDGILL MARK, KUMARAVEL GNANASAMBANDAM, TYE HEATHER, KRULLE THOMAS, KERRY PHILIP
Year of Publication 04.09.2018
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Year of Publication 04.09.2018
Patent
An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction
EAST, Stephen P, BAMFORD, Samantha, PUI LOKE, SCHÄNZLE, Gerhard, SCHUBERT, Hans-Dieter, SCOTT, John, WHITTAKER, Mark, WILLIAMS, Mildred, ZAWADZKI, Przemyslaw, GERLACH, Kai, DIETZ, Matthias G. A, EICKMEIER, Christian, FLEGG, Adam, FERGER, Boris, GEMKOW, Mark J, HEILKER, Ralf, HENGERER, Bastian, KOTEY, Adrian
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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An orally bioavailable positive allosteric modulator of the mGlu sub(4) receptor with efficacy in an animal model of motor dysfunction
East, Stephen P, Bamford, Samantha, Dietz, Matthias GA, Eickmeier, Christian, Flegg, Adam, Ferger, Boris, Gemkow, Mark J, Heilker, Ralf, Hengerer, Bastian, Kotey, Adrian, Loke, Pui, Schaenzle, Gerhard, Schubert, Hans-Dieter, Scott, John, Whittaker, Mark, Williams, Mildred, Zawadzki, Przemyslaw, Gerlach, Kai
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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COMPOUNDS FOR TREATING CANCER
ICHIHARA OSAMU, KOTEY ADRIAN KOTEI, EAST STEPHEN PETER, WHITTAKER MARK, BAMFORD JAYNE SAMANTHA
Year of Publication 31.08.2011
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Year of Publication 31.08.2011
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Compounds and probes for imaging huntingtin protein
Johnson, Peter David, Brown, Christopher John, Prime, Michael Edward, Lee, Matthew, Liu, Longbin, Dominguez, Celia, Mills, Matthew Robert, Hayes, Sarah, Kotey, Adrian
Year of Publication 28.05.2024
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Year of Publication 28.05.2024
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HETEROARYL-DERIVATER SOM SEPIAPTERIN-REDUKTASE-INHIBITORER
KOTEY, Adrian, Kotei, RIDGILL, Mark, Peter, AVERY, Craig, MCCALL, John, Michael, TEBBE, Mark, Joseph, JOHNSSON, Kai, Peter, GORSKA, Katarzyna, Irena, TYE, Heather, ATTON, Holly, Victoria, BROMIDGE, Steven, Mark, MONCK, Nathaniel, J, MENICONI, Mirco, KERRY, Mark, PENG, Hairuo, SAIAH, Eddine
Year of Publication 12.02.2024
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Year of Publication 12.02.2024
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HETEROARYL DERIVATIVES AS SEPIAPTERIN REDUCTASE INHIBITORS
KOTEY, Adrian, Kotei, RIDGILL, Mark, Peter, AVERY, Craig, MCCALL, John, Michael, TEBBE, Mark, Joseph, JOHNSSON, Kai, Peter, GORSKA, Katarzyna, Irena, TYE, Heather, ATTON, Holly, Victoria, BROMIDGE, Steven, Mark, MONCK, Nathaniel, J, MENICONI, Mirco, KERRY, Mark, PENG, Hairuo, SAIAH, Eddine
Year of Publication 08.11.2023
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Year of Publication 08.11.2023
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COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN
KOTEY, Adrian, DOMINGUEZ, Celia, BROWN, Christopher John, HAYES, Sarah, MILLS, Matthew Robert, JOHNSON, Peter David, LIU, Longbin, PRIME, Michael Edward, LEE, Matthew
Year of Publication 26.10.2022
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Year of Publication 26.10.2022
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AZA-BENZIMIDAZOLE INHIBITORS OF PAD4
DEVRAJ, Rajesh, KOTEY, Adrian, WIGGINTON, Ian, KUMARAVEL, Gnanasambandam, KRULLE, Thomas, TYE, Heather, GLEAVE, Laura, LECCI, Cristina
Year of Publication 23.09.2020
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Year of Publication 23.09.2020
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Compounds and probes for imaging huntingtin protein
KOTEY, Adrian, DOMINGUEZ, Celia, BROWN, Christopher John, HAYES, Sarah, MILLS, Matthew Robert, JOHNSON, Peter David, LIU, Longbin, PRIME, Michael Edward, LEE, Matthew
Year of Publication 30.06.2022
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Year of Publication 30.06.2022
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COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN
Johnson, Peter David, Brown, Christopher John, Prime, Michael Edward, Lee, Matthew, Liu, Longbin, Dominguez, Celia, Mills, Matthew Robert, Hayes, Sarah, Kotey, Adrian
Year of Publication 05.08.2021
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Year of Publication 05.08.2021
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COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN
KOTEY, Adrian, DOMINGUEZ, Celia, BROWN, Christopher John, HAYES, Sarah, MILLS, Matthew Robert, JOHNSON, Peter David, LIU, Longbin, PRIME, Michael Edward, LEE, Matthew
Year of Publication 24.06.2021
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Year of Publication 24.06.2021
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AZA-BENZIMIDAZOLE INHIBITORS OF PAD4
DEVRAJ, Rajesh, KOTEY, Adrian, WIGGINTON, Ian, KUMARAVEL, Gnanasambandam, KRULLE, Thomas, TYE, Heather, GLEAVE, Laura, LECCI, Cristina
Year of Publication 26.06.2019
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Year of Publication 26.06.2019
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