Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models
Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
Get full text
Journal Article
Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity
Wengner, Antje M, Siemeister, Gerhard, Koppitz, Marcus, Schulze, Volker, Kosemund, Dirk, Klar, Ulrich, Stoeckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Raschke, Marian, Frisk, Anna-Lena, von Ahsen, Oliver, Michels, Martin, Kreft, Bertolt, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl
Published in Molecular cancer therapeutics (01.04.2016)
Published in Molecular cancer therapeutics (01.04.2016)
Get full text
Journal Article
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase
Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
Get full text
Journal Article
Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis
Koppitz, Marcus, Bräuer, Nico, Ter Laak, Antonius, Irlbacher, Horst, Rotgeri, Andrea, Coelho, Anne-Marie, Walter, Daryl, Steinmeyer, Andreas, Zollner, Thomas M., Peters, Michaele, Nagel, Jens
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Get full text
Journal Article
Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo
Wortmann, Lars, Lindenthal, Bernhard, Muhn, Peter, Walter, Alexander, Nubbemeyer, Reinhard, Heldmann, Dieter, Sobek, Lothar, Morandi, Federica, Schrey, Anna K, Moosmayer, Dieter, Günther, Judith, Kuhnke, Joachim, Koppitz, Marcus, Lücking, Ulrich, Röhn, Ulrike, Schäfer, Martina, Nowak-Reppel, Katrin, Kühne, Ronald, Weinmann, Hilmar, Langer, Gernot
Published in Journal of medicinal chemistry (27.11.2019)
Published in Journal of medicinal chemistry (27.11.2019)
Get full text
Journal Article
Abstract 4540: SAC abrogation by MPS1 kinase inhibition: preclinical proof of concept of a novel approach to tumor treatment
Mumberg, Dominik, Siemeister, Gerhard, Wengner, Antje M., Koppitz, Marcus, Schulze, Volker, Bader, Benjamin, Prechtl, Stefan, Kreft, Bertolt, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article
Abstract 3090: Novel Mps1 kinase inhibitors with potent anti-tumor activity
Wengner, Antje Margret, Siemeister, Gerhard, Koppitz, Marcus, Schulze, Volker, Kosemund, Dirk, Klar, Ulrich, Stoeckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Doehr, Olaf, Raschke, Marian, von Ahsen, Oliver, Elbi, Cem, Bruns, Ingmar, Michels, Martin, Kreft, Bertolt, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Abstract 706: Novel MPS1 inhibitors with potential anticancer activity
Wengner, Antje, Jemaà, Mohamed, Galluzzi, Lorenzo, Kepp, Oliver, Brands, Michael, Koppitz, Marcus, Schulze, Volker, Siemeister, Gerhard, Mumberg, Dominik, Ziegelbauer, Karl, Castedo, Maria, Vitale, Ilio, Kroemer, Guido
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article
2--4--17- 2-MORPHOLIN-4-YL-17-NAPHTHYRIDINES
BADER BENJAMIN, LIENAU PHILIP, MOOSMAYER DIETER, EBERSPAECHER UWE, GRUDZINSKA GOEBEL JOANNA, KOPPITZ MARCUS, VON NUSSBAUM FRANZ, SIEMEISTER GERHARD, EIS KNUT, WORTMANN LARS, BONE WILHELM, WENGNER ANTJE MARGRET, LEFRANC JULIEN, BRIEM HANS, LUECKING ULRICH, SCHICK HANS
Year of Publication 19.11.2020
Get full text
Year of Publication 19.11.2020
Patent
P2X3 억제제로서의 신규 피라졸로-피롤로-피리미딘-디온 유도체
CARR JAMES LINDSAY, SIEBENEICHER HOLGER, CONNELLY URSINYOVA NINA, KOPPITZ MARCUS, PARROTT SHELLEY ANNE, POOK ELISABETH, BRAEUER NICO, ROTGERI ANDREA, NAGEL JENS, NEUHAUS ROLAND, DAVENPORT ADAM JAMES, TOWNSEND ROBERT JAMES, FISCHER OLIVER MARTIN
Year of Publication 01.07.2020
Get full text
Year of Publication 01.07.2020
Patent
[8--3,8-디아자비사이클로[3.2.1]옥트-3-일](1H-1,2,3-트리아졸-4-일)메타논
BADER BENJAMIN, SIEBENEICHER HOLGER, TEREBESI ILDIKO, ROTTMANN ANTJE, KOPPITZ MARCUS, PETERS MICHAELE, WAGENFELD ANDREA, IRLBACHER HORST, NUBBEMEYER REINHARD, TER LAAK ANTONIUS, STEUBER HOLGER
Year of Publication 28.01.2019
Get full text
Year of Publication 28.01.2019
Patent
SUBSTITUTED PYRIDYL-CYCLOALKYL-CARBOXYLIC ACIDS COMPOSITIONS CONTAINING THEM AND MEDICAL USES THEREOF
GODINHO COELHO ANNE MARIE, ROTGERI ANDREA, KOPPITZ MARCUS, NAGEL JENS, PETERS MICHAELE, IRLBACHER HORST, SCHWEDE WOLFGANG, BRAEUER NICO, DAHLLOEF HENRIK
Year of Publication 30.08.2017
Get full text
Year of Publication 30.08.2017
Patent
SUBSTITUTED IMIDAZOPYRIDAZINES
KOPPITZ MARCUS, WENGNER ANTJE MARGRET, SIEMEISTER GERHARD, KLAR ULRICH, BRUENING MICHAEL, NEUHAUS ROLAND
Year of Publication 09.11.2015
Get full text
Year of Publication 09.11.2015
Patent
아미도-치환된 시클로헥산 유도체
SIEGEL FRANZISKA, LIENAU PHILIP, KOPPITZ MARCUS, BUCHGRABER PHILIPP, BENDER ECKHARD, VON NUSSBAUM FRANZ, LIU NINGSHU, EIS KNUT, SUELZLE DETLEV, BAIRLEIN MICHAELA, LI VOLKHART, ACKERSTAFF JENS, WAGNER SARAH, HOLTON SIMON, HERBERT SIMON ANTHONY
Year of Publication 08.01.2018
Get full text
Year of Publication 08.01.2018
Patent
Solid-phase synthesis of substituted 3-amino-3′-carboxy-tetrahydrocarbazoles
Koppitz, Marcus, Reinhardt, Gabriele, van Lingen, Anneke
Published in Tetrahedron letters (07.02.2005)
Published in Tetrahedron letters (07.02.2005)
Get full text
Journal Article
2--4--L7- 2-MORPHOLIN-4-YL-L7-NAPHTHYRIDINES
BADER BENJAMIN, LIENAU PHILIP, MOOSMAYER DIETER, EBERSPAECHER UWE, GRUDZINSKA GOEBEL JOANNA, KOPPITZ MARCUS, VON NUSSBAUM FRANZ, SIEMEISTER GERHARD, EIS KNUT, WORTMANN LARS, BONE WILHELM, WENGNER ANTJE MARGRET, LEFRANC JULIEN, BRIEM HANS, LUECKING ULRICH, SCHICK HANS
Year of Publication 12.04.2017
Get full text
Year of Publication 12.04.2017
Patent
SUBSTITUTED IMIDAZOPYRIDAZINES
LIENAU PHILIP, KOPPITZ MARCUS, BOHLMANN ROLF, WENGNER ANTJE MARGRET, KOSEMUND DIRK, SIEMEISTER GERHARD, JAUTELAT ROLF, KLAR ULRICH
Year of Publication 14.03.2014
Get full text
Year of Publication 14.03.2014
Patent
SUBSTITUTED TRIAZOLOPYRIDINES
BADER BENJAMIN, LIENAU PHILIP, KOPPITZ MARCUS, KOSEMUND DIRK, SIEMEISTER GERHARD, SCHIROK HARTMUT, PRECHTL STEFAN, PRIEN OLAF, HOLTON SIMON, SCHULZE VOLKER, WENGNER ANTJE MARGRET, STOECKIGT DETLEF, BRIEM HANS
Year of Publication 22.10.2013
Get full text
Year of Publication 22.10.2013
Patent