MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition
Vande Walle, Lieselotte, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubrt, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed
Published in PLoS biology (16.09.2019)
Published in PLoS biology (16.09.2019)
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Journal Article
The yeast proteases Ddi1 and Wss1 are both involved in the DNA replication stress response
Svoboda, Michal, Konvalinka, Jan, Trempe, Jean-François, Grantz Saskova, Klara
Published in DNA repair (01.08.2019)
Published in DNA repair (01.08.2019)
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Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase
Gregor, Jiří, Radilová, Kateřina, Brynda, Jiří, Fanfrlík, Jindřich, Konvalinka, Jan, Kožíšek, Milan
Published in Molecules (Basel, Switzerland) (14.02.2021)
Published in Molecules (Basel, Switzerland) (14.02.2021)
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Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors
Zima, Václav, Radilová, Kateřina, Kožíšek, Milan, Albiñana, Carlos Berenguer, Karlukova, Elena, Brynda, Jiří, Fanfrlík, Jindřich, Flieger, Miroslav, Hodek, Jan, Weber, Jan, Majer, Pavel, Konvalinka, Jan, Machara, Aleš
Published in European journal of medicinal chemistry (15.12.2020)
Published in European journal of medicinal chemistry (15.12.2020)
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Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery
Kryštůfek, Robin, Šácha, Pavel, Starková, Jana, Brynda, Jiří, Hradilek, Martin, Tloušt’ová, Eva, Grzymska, Justyna, Rut, Wioletta, Boucher, Michael J, Drąg, Marcin, Majer, Pavel, Hájek, Miroslav, Řezáčová, Pavlína, Madhani, Hiten D, Craik, Charles S, Konvalinka, Jan
Published in Journal of medicinal chemistry (27.05.2021)
Published in Journal of medicinal chemistry (27.05.2021)
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Journal Article
Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors
Reiberger, Robert, Radilová, Kateřina, Kráľ, Michal, Zima, Václav, Majer, Pavel, Brynda, Jiří, Dračínský, Martin, Konvalinka, Jan, Kožíšek, Milan, Machara, Aleš
Published in International journal of molecular sciences (20.07.2021)
Published in International journal of molecular sciences (20.07.2021)
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Malonate-based inhibitors of mammalian serine racemase: Kinetic characterization and structure-based computational study
Vorlová, Barbora, Nachtigallová, Dana, Jirásková-Vaníčková, Jana, Ajani, Haresh, Jansa, Petr, Řezáč, Jan, Fanfrlík, Jindřich, Otyepka, Michal, Hobza, Pavel, Konvalinka, Jan, Lepšík, Martin
Published in European journal of medicinal chemistry (07.01.2015)
Published in European journal of medicinal chemistry (07.01.2015)
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Journal Article
structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor
Hejdánek, Jakub, Radilová, Kateřina, Pachl, Petr, Hodek, Jan, Machara, Aleš, Weber, Jan, Řezáčová, Pavlína, Konvalinka, Jan, Kožíšek, Milan
Published in Antiviral research (01.01.2021)
Published in Antiviral research (01.01.2021)
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Factors, associated with elevated concentration of soluble carbonic anhydrase IX in plasma of women with cervical dysplasia
Grincevičienė, Švitrigailė, Vaitkienė, Daiva, Kanopienė, Daiva, Vansevičiūtė, Rasa, Tykvart, Jan, Sukovas, Artūras, Celiešiūtė, Joana, Ivanauskaitė Didžiokienė, Ernesta, Čižauskas, Arvydas, Laurinavičienė, Aida, Král, Vlastimil, Hlavačková, Anna, Zemanová, Jitka, Stravinskienė, Dovilė, Sližienė, Aistė, Petrošiūtė, Agnė, Petrauskas, Vytautas, Balsytė, Renata, Grincevičius, Jonas, Navratil, Vaclav, Jahn, Ullrich, Konvalinka, Jan, Žvirblienė, Aurelija, Matulis, Daumantas, Matulienė, Jurgita
Published in Scientific reports (13.09.2022)
Published in Scientific reports (13.09.2022)
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Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer
Mesters, Jeroen R, Barinka, Cyril, Li, Weixing, Tsukamoto, Takashi, Majer, Pavel, Slusher, Barbara S, Konvalinka, Jan, Hilgenfeld, Rolf
Published in The EMBO journal (22.03.2006)
Published in The EMBO journal (22.03.2006)
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Specific Inhibitors of HIV Capsid Assembly Binding to the C‑Terminal Domain of the Capsid Protein: Evaluation of 2‑Arylquinazolines as Potential Antiviral Compounds
Machara, Aleš, Lux, Vanda, Kožíšek, Milan, Grantz Šašková, Klára, Štěpánek, Ondřej, Kotora, Martin, Parkan, Kamil, Pávová, Marcela, Glass, Bärbel, Sehr, Peter, Lewis, Joe, Müller, Barbara, Kräusslich, Hans-Georg, Konvalinka, Jan
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
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Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog
Sivá, Monika, Svoboda, Michal, Veverka, Václav, Trempe, Jean-François, Hofmann, Kay, Kožíšek, Milan, Hexnerová, Rozálie, Sedlák, František, Belza, Jan, Brynda, Jiří, Šácha, Pavel, Hubálek, Martin, Starková, Jana, Flaisigová, Iva, Konvalinka, Jan, Šašková, Klára Grantz
Published in Scientific reports (27.07.2016)
Published in Scientific reports (27.07.2016)
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Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes
Řezáčová, Pavlína, Pokorná, Jana, Brynda, Jiří, Kožíšek, Milan, Cígler, Petr, Lepšík, Martin, Fanfrlík, Jindřich, Řezáč, Jan, Grantz Šašková, Klára, Sieglová, Irena, Plešek, Jaromír, Šícha, Václav, Grüner, Bohumír, Oberwinkler, Heike, Sedláček’, Juraj, Kräusslich, Hans-Georg, Hobza, Pavel, Král, Vladimír, Konvalinka, Jan
Published in Journal of medicinal chemistry (26.11.2009)
Published in Journal of medicinal chemistry (26.11.2009)
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Journal Article
From Nonpeptide toward Noncarbon Protease Inhibitors: Metallacarboranes as Specific and Potent Inhibitors of HIV Protease
Petr Cígler, Milan Kožíšek, Pavlína Řezáčová, Jíří Brynda, Otwinowski, Zbyszek, Jana Pokorná, Jaromír Plešek, Bohumír Grüner, Lucie Dolečková-Marešová, Martin Máša, Juraj Sedláček, Jochen Bodem, Kräusslich, Hans-Georg, Král, Vladimír, Jan Konvalinka
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2005)
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Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus
Pokorná, Jana, Pachl, Petr, Karlukova, Elena, Hejdánek, Jakub, Řezáčová, Pavlína, Machara, Aleš, Hudlický, Jason, Konvalinka, Jan, Kožíšek, Milan
Published in Viruses (21.06.2018)
Published in Viruses (21.06.2018)
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Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor
Schimer, Jiří, Pávová, Marcela, Anders, Maria, Pachl, Petr, Šácha, Pavel, Cígler, Petr, Weber, Jan, Majer, Pavel, Řezáčová, Pavlína, Kräusslich, Hans-Georg, Müller, Barbara, Konvalinka, Jan
Published in Nature communications (09.03.2015)
Published in Nature communications (09.03.2015)
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Current and Novel Inhibitors of HIV Protease
Pokorná, Jana, Machala, Ladislav, Rezáčová, Pavlína, Konvalinka, Jan
Published in Viruses (01.12.2009)
Published in Viruses (01.12.2009)
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Book Review
Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition
Walle, Lieselotte Vande, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubr, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed
Published in PLoS biology (16.10.2019)
Published in PLoS biology (16.10.2019)
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Journal Article
Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII
Knedlík, Tomáš, Vorlová, Barbora, Navrátil, Václav, Tykvart, Jan, Sedlák, František, Vaculín, Šimon, Franěk, Miloslav, Šácha, Pavel, Konvalinka, Jan
Published in FEBS open bio (01.09.2017)
Published in FEBS open bio (01.09.2017)
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