Development of an In Silico Prediction Model for P‑glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration
Watanabe, Reiko, Esaki, Tsuyoshi, Ohashi, Rikiya, Kuroda, Masataka, Kawashima, Hitoshi, Komura, Hiroshi, Natsume-Kitatani, Yayoi, Mizuguchi, Kenji
Published in Journal of medicinal chemistry (11.03.2021)
Published in Journal of medicinal chemistry (11.03.2021)
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Journal Article
Application of a Physiologically Based Pharmacokinetic Model Informed by a Top-Down Approach for the Prediction of Pharmacokinetics in Chronic Kidney Disease Patients
Sayama, Hiroyuki, Takubo, Hiroaki, Komura, Hiroshi, Kogayu, Motohiro, Iwaki, Masahiro
Published in The AAPS journal (01.09.2014)
Published in The AAPS journal (01.09.2014)
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Journal Article
Prediction of Hepatic Clearance of Stereoselective Metabolism of Carvedilol in Liver Microsomes and Hepatocytes of Sprague-Dawley and Cytochrome P450 2D-Deficient Dark Agouti Rats
Iwaki, Masahiro, Niwa, Toshiro, Tanaka, Hiroyuki, Kawase, Atsushi, Komura, Hiroshi
Published in Journal of pharmacy & pharmaceutical sciences (2019)
Published in Journal of pharmacy & pharmaceutical sciences (2019)
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Journal Article
Application of hybrid approach based on empirical and physiological concept for predicting pharmacokinetics in humans--usefulness of exponent on prospective evaluation of predictability
Sayama, Hiroyuki, Komura, Hiroshi, Kogayu, Motohiro
Published in Drug metabolism and disposition (01.02.2013)
Published in Drug metabolism and disposition (01.02.2013)
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Journal Article
Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol
Iwaki, Masahiro, Niwa, Toshiro, Bandoh, Saya, Itoh, Megumi, Hirose, Hitomi, Kawase, Atsushi, Komura, Hiroshi
Published in Drug metabolism and pharmacokinetics (01.12.2016)
Published in Drug metabolism and pharmacokinetics (01.12.2016)
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Journal Article
Plasma levels of natriuretic peptides and development of chronic kidney disease
Ogawa, Noriyuki, Komura, Hiroshi, Kuwasako, Kenji, Kitamura, Kazuo, Kato, Johji
Published in BMC nephrology (24.10.2015)
Published in BMC nephrology (24.10.2015)
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Journal Article
Gender difference in relationship between body mass index and development of chronic kidney disease
Komura, Hiroshi, Nomura, Ikuo, Kitamura, Kazuo, Kuwasako, Kenji, Kato, Johji
Published in BMC research notes (13.11.2013)
Published in BMC research notes (13.11.2013)
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Journal Article
Differences in Cytochrome P450 and Nuclear Receptor mRNA Levels in Liver and Small Intestines between SD and DA Rats
Kawase, Atsushi, Fujii, Akiyuki, Negoro, Makiko, Akai, Ryosuke, Ishikubo, Miki, Komura, Hiroshi, Iwaki, Masahiro
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2008)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2008)
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Journal Article
Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4
Okigami, Hiromi, Takeshita, Keisuke, Tajimi, Masaomi, Komura, Hiroshi, Albers, Markus, Lehmann, Thomas E., Rölle, Thomas, Bacon, Kevin B.
Published in European journal of pharmacology (22.03.2007)
Published in European journal of pharmacology (22.03.2007)
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Journal Article
Application of substrate depletion assay for early prediction of nonlinear pharmacokinetics in drug discovery: Assessment of nonlinearity of metoprolol, timolol, and propranolol
Komura, Hiroshi, Kawase, Atsushi, Iwaki, Masahiro
Published in Journal of pharmaceutical sciences (01.12.2005)
Published in Journal of pharmaceutical sciences (01.12.2005)
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Journal Article
Strain Differences in the Induction of Cytochrome P450 3A1/3A2 and Nuclear Receptors in the Liver by Phenobarbital and Dexamethasone in Sprague-Dawley Rats and Dark Agouti Rats
Kawase, Atsushi, Otori, Toru, Fujii, Akiyuki, Yamada, Ayano, Komura, Hiroshi, Iwaki, Masahiro
Published in Journal of Health Science (2011)
Published in Journal of Health Science (2011)
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Journal Article
DruMAP: A Novel Drug Metabolism and Pharmacokinetics Analysis Platform
Kawashima, Hitoshi, Watanabe, Reiko, Esaki, Tsuyoshi, Kuroda, Masataka, Nagao, Chioko, Natsume-Kitatani, Yayoi, Ohashi, Rikiya, Komura, Hiroshi, Mizuguchi, Kenji
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Journal Article
A public–private partnership to enrich the development of in silico predictive models for pharmacokinetic and cardiotoxic properties
Komura, Hiroshi, Watanabe, Reiko, Kawashima, Hitoshi, Ohashi, Rikiya, Kuroda, Masataka, Sato, Tomohiro, Honma, Teruki, Mizuguchi, Kenji
Published in Drug discovery today (01.05.2021)
Published in Drug discovery today (01.05.2021)
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Journal Article