Novel non‐steroidal mineralocorticoid receptor antagonists in cardiorenal disease
Kintscher, Ulrich, Bakris, George L., Kolkhof, Peter
Published in British journal of pharmacology (01.07.2022)
Published in British journal of pharmacology (01.07.2022)
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Journal Article
Molecular mechanisms and therapeutic targets for diabetic kidney disease
Tuttle, Katherine R., Agarwal, Rajiv, Alpers, Charles E., Bakris, George L., Brosius, Frank C., Kolkhof, Peter, Uribarri, Jaime
Published in Kidney international (01.08.2022)
Published in Kidney international (01.08.2022)
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Journal Article
Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes
Bakris, George L, Agarwal, Rajiv, Anker, Stefan D, Pitt, Bertram, Ruilope, Luis M, Rossing, Peter, Kolkhof, Peter, Nowack, Christina, Schloemer, Patrick, Joseph, Amer, Filippatos, Gerasimos
Published in The New England journal of medicine (03.12.2020)
Published in The New England journal of medicine (03.12.2020)
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Journal Article
Nonsteroidal antagonists of the mineralocorticoid receptor
Kolkhof, Peter, Nowack, Christina, Eitner, Frank
Published in Current opinion in nephrology and hypertension (01.09.2015)
Published in Current opinion in nephrology and hypertension (01.09.2015)
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Journal Article
The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling
Barrera-Chimal, Jonatan, Estrela, Gabriel R., Lechner, Sebastian M., Giraud, Sébastien, El Moghrabi, Soumaya, Kaaki, Shiem, Kolkhof, Peter, Hauet, Thierry, Jaisser, Frédéric
Published in Kidney international (01.06.2018)
Published in Kidney international (01.06.2018)
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Journal Article
Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone’s Antifibrotic Activity
Grune, Jana, Beyhoff, Niklas, Smeir, Elia, Chudek, Remigiusz, Blumrich, Annelie, Ban, Zsofia, Brix, Sarah, Betz, Iris R, Schupp, Michael, Foryst-Ludwig, Anna, Klopfleisch, Robert, Stawowy, Philipp, Houtman, René, Kolkhof, Peter, Kintscher, Ulrich
Published in Hypertension (Dallas, Tex. 1979) (01.04.2018)
Published in Hypertension (Dallas, Tex. 1979) (01.04.2018)
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Journal Article
Nonsteroidal Mineralocorticoid Receptor Antagonism by Finerenone-Translational Aspects and Clinical Perspectives across Multiple Organ Systems
Kolkhof, Peter, Lawatscheck, Robert, Filippatos, Gerasimos, Bakris, George L
Published in International journal of molecular sciences (17.08.2022)
Published in International journal of molecular sciences (17.08.2022)
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Journal Article
Steroidal and Novel Non-steroidal Mineralocorticoid Receptor Antagonists in Heart Failure and Cardiorenal Diseases: Comparison at Bench and Bedside
Kolkhof, Peter, Jaisser, Frederic, Kim, So-Young, Filippatos, Gerasimos, Nowack, Christina, Pitt, Bertram
Published in Handbook of experimental pharmacology (01.01.2017)
Published in Handbook of experimental pharmacology (01.01.2017)
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Book Chapter
Journal Article
Differentiation between emerging non-steroidal and established steroidal mineralocorticoid receptor antagonists: head-to-head comparisons of pharmacological and clinical characteristics
Barrera-Chimal, Jonatan, Kolkhof, Peter, Lima-Posada, Ixchel, Alexandre, Joachim, Rossignol, Patrick, Jaisser, Frederic
Published in Expert opinion on investigational drugs (02.11.2021)
Published in Expert opinion on investigational drugs (02.11.2021)
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Journal Article
Direct Blood Pressure-Independent Anti-Fibrotic Effects by the Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone in Progressive Models of Kidney Fibrosis
Droebner, Karoline, Pavkovic, Mira, Grundmann, Manuel, Hartmann, Elke, Goea, Laura, Nordlohne, Johannes, Klar, Jürgen, Eitner, Frank, Kolkhof, Peter
Published in American journal of nephrology (01.09.2021)
Published in American journal of nephrology (01.09.2021)
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Journal Article
Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
Gerisch, Michael, Heinig, Roland, Engelen, Anna, Lang, Dieter, Kolkhof, Peter, Radtke, Martin, Platzek, Johannes, Lovis, Kai, Rohde, Gabriele, Schwarz, Thomas
Published in Drug metabolism and disposition (01.11.2018)
Published in Drug metabolism and disposition (01.11.2018)
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Journal Article
Effect of finerenone on ambulatory blood pressure in chronic kidney disease in type 2 diabetes
Agarwal, Rajiv, Ruilope, Luis M, Ruiz-Hurtado, Gema, Haller, Hermann, Schmieder, Roland E, Anker, Stefan D, Filippatos, Gerasimos, Pitt, Bertram, Rossing, Peter, Lambelet, Marc, Nowack, Christina, Kolkhof, Peter, Joseph, Amer, Bakris, George L
Published in Journal of hypertension (01.02.2023)
Published in Journal of hypertension (01.02.2023)
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Journal Article
Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1
Amazit, Larbi, Le Billan, Florian, Kolkhof, Peter, Lamribet, Khadija, Viengchareun, Say, Fay, Michel R., Khan, Junaid A., Hillisch, Alexander, Lombès, Marc, Rafestin-Oblin, Marie-Edith, Fagart, Jérôme
Published in The Journal of biological chemistry (04.09.2015)
Published in The Journal of biological chemistry (04.09.2015)
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Journal Article
Antagonistic effects of finerenone and spironolactone on the aldosterone-regulated transcriptome of human kidney cells
Le Billan, Florian, Perrot, Julie, Carceller, Elena, Travers, Simon, Viengchareun, Say, Kolkhof, Peter, Lombès, Marc, Fagart, Jérôme
Published in The FASEB journal (01.02.2021)
Published in The FASEB journal (01.02.2021)
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Journal Article
Design and Baseline Characteristics of the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease Trial
Bakris, George L., Agarwal, Rajiv, Anker, Stefan D., Pitt, Bertram, Ruilope, Luis M., Nowack, Christina, Kolkhof, Peter, Ferreira, Anna C., Schloemer, Patrick, Filippatos, Gerasimos
Published in American journal of nephrology (2019)
Published in American journal of nephrology (2019)
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Journal Article
Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1
Barrera-Chimal, Jonatan, André-Grégoire, Gwennan, Nguyen Dinh Cat, Aurelie, Lechner, Sebastian M, Cau, Jérôme, Prince, Sonia, Kolkhof, Peter, Loirand, Gervaise, Sauzeau, Vincent, Hauet, Thierry, Jaisser, Frédéric
Published in Journal of the American Society of Nephrology (01.04.2017)
Published in Journal of the American Society of Nephrology (01.04.2017)
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Journal Article