ABT-963 [2-(3,4-Difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], A Highly Potent and Selective Disubstituted Pyridazinone Cyclooxgenase-2 Inhibitor
Harris, Richard R, Black, Lawrence, Surapaneni, Sekhar, Kolasa, Teodozyj, Majest, Sandra, Namovic, Marian T, Grayson, George, Komater, Victoria, Wilcox, Denise, King, Linda, Marsh, Kennan, Jarvis, Michael F, Nuss, Merrill, Nellans, Hugh, Pruesser, Lee, Reinhart, Glenn A, Cox, Bryan, Jacobson, Peer, Stewart, Andrew, Coghlan, Michael, Carter, George, Bell, Randy L
Published in The Journal of pharmacology and experimental therapeutics (01.12.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2004)
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Journal Article
Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats
Polakowski, James S, Segreti, Jason A, Cox, Bryan F, Hsieh, Gin C, Kolasa, Teodozyj, Moreland, Robert B, Brioni, Jorge D
Published in Clinical and experimental pharmacology & physiology (01.12.2004)
Published in Clinical and experimental pharmacology & physiology (01.12.2004)
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Journal Article
Synthesis and Structure−Activity Studies on N-[5-(1H-Imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an Imidazole-Containing α1A-Adrenoceptor Agonist
Altenbach, Robert J, Khilevich, Albert, Kolasa, Teodozyj, Rohde, Jeffrey J, Bhatia, Pramila A, Patel, Meena V, Searle, Xenia B, Yang, Fan, Bunnelle, William H, Tietje, Karin, Bayburt, Erol K, Carroll, William A, Meyer, Michael D, Henry, Rodger, Buckner, Steven A, Kuk, Jane, Daza, Anthony V, Milicic, Ivan V, Cain, John C, Kang, Chae H, Ireland, Lynne M, Carr, Tracy L, Miller, Thomas R, Hancock, Arthur A, Nakane, Masaki, Esbenshade, Timothy A, Brune, Michael E, O'Neill, Alyssa B, Gauvin, Donna M, Katwala, Sweta P, Holladay, Mark W, Brioni, Jorge D, Sullivan, James P
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Journal Article
Nonsteroidal Anti-Inflammatory Drugs as Scaffolds for the Design of 5-Lipoxygenase Inhibitors
Kolasa, Teodozyj, Brooks, Clint D. W, Rodriques, Karen E, Summers, James B, Dellaria, Joseph F, Hulkower, Keren I, Bouska, Jennifer, Bell, Randy L, Carter, George W
Published in Journal of medicinal chemistry (28.02.1997)
Published in Journal of medicinal chemistry (28.02.1997)
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Journal Article
Synthesis of 4,5-Diaryl-1H-pyrazole-3-ol Derivatives as Potential COX-2 Inhibitors
Patel, Meena V, Bell, Randy, Majest, Sandra, Henry, Rodger, Kolasa, Teodozyj
Published in Journal of organic chemistry (15.10.2004)
Published in Journal of organic chemistry (15.10.2004)
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Journal Article
Structure−Activity Relationship of Triazafluorenone Derivatives as Potent and Selective mGluR1 Antagonists
Zheng, Guo Zhu, Bhatia, Pramila, Daanen, Jerome, Kolasa, Teodozyj, Patel, Meena, Latshaw, Steven, El Kouhen, Odile F, Chang, Renjie, Uchic, Marie E, Miller, Loan, Nakane, Masaki, Lehto, Sonya G, Honore, Marie P, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O
Published in Journal of medicinal chemistry (17.11.2005)
Published in Journal of medicinal chemistry (17.11.2005)
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Journal Article
Discovery of 3-methyl-N-(1-oxy-3 ',4 ',5 ',6 '-tetrahydro-2 ' H-[2,4 '-bipyridine]-1 '-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D-4 agonist for the treatment of erectile dysfunction
Patel, Meena V., Kolasa, Teodozyj, Mortell, Kathleen, Matulenko, Mark A., Hakeem, Ahmed A., Rohde, Jeffrey J., Nelson, Sherry L., Cowart, Marlon D., Nakane, Masaki, Miller, Loan N., Uchic, Marie E., Terranova, Marc A., El-Kouhen, Odile F., Donnelly-Roberts, Diana L., Namovic, Marian T., Hollingsworth, Peter R., Chang, Renjie, Martino, Brenda R., Wetter, Jill M., Marsh, Kennan C., Martin, Ruth, Darbyshire, John F., Gintant, Gary, Hsieh, Gin C., Moreland, Robert B., Sullivan, James P., Brioni, Jorge D., Stewart, Andrew O.
Published in Journal of medicinal chemistry (14.12.2006)
Published in Journal of medicinal chemistry (14.12.2006)
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Journal Article
Discovery of 3-Methyl-N-(1-oxy-3‘,4‘,5‘,6‘-tetrahydro-2‘H-[2,4‘-bipyridine]-1‘-ylmethyl)benzamide (ABT-670), an Orally Bioavailable Dopamine D4 Agonist for the Treatment of Erectile Dysfunction
Patel, Meena V, Kolasa, Teodozyj, Mortell, Kathleen, Matulenko, Mark A, Hakeem, Ahmed A, Rohde, Jeffrey J, Nelson, Sherry L, Cowart, Marlon D, Nakane, Masaki, Miller, Loan N, Uchic, Marie E, Terranova, Marc A, El-Kouhen, Odile F, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Chang, Renjie, Martino, Brenda R, Wetter, Jill M, Marsh, Kennan C, Martin, Ruth, Darbyshire, John F, Gintant, Gary, Hsieh, Gin C, Moreland, Robert B, Sullivan, James P, Brioni, Jorge D, Stewart, Andrew O
Published in Journal of medicinal chemistry (14.12.2006)
Published in Journal of medicinal chemistry (14.12.2006)
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Journal Article
1-Aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D-4 receptor agonists for the treatment of erectile dysfunction
Kolasa, Teodozyj, Matulenko, Mark A., Hakeem, Ahmed A., Patel, Meena V., Mortell, Kathleen, Bhatia, Pramila, Henry, Rodger, Nakane, Masaki, Hsieh, Gin C., Terranova, Marc A., Uchic, Marie E., Miller, Loan N., Chang, Renje, Donnelly-Roberts, Diana L., Namovic, Marian T., Hollingsworth, Peter R., Martino, Brenda, El Kouhen, Odile, Marsh, Kennan C., Wetter, Jill M., Moreland, Robert B., Brioni, Jorge D., Stewart, Andrew O.
Published in Journal of medicinal chemistry (24.08.2006)
Published in Journal of medicinal chemistry (24.08.2006)
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Journal Article
Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists
Zheng, Guo Zhu, Bhatia, Pramila, Kolasa, Teodozyj, Patel, Meena, El Kouhen, Odile F., Chang, Renjie, Uchic, Marie E., Miller, Loan, Baker, Scott, Lehto, Sonya G., Honore, Prisca, Wetter, Jill M., Marsh, Kennan C., Moreland, Robert B., Brioni, Jorge D., Stewart, Andrew O.
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Journal Article
An efficient one-pot synthesis of substituted 2-arylbenzo[ b]thiophene derivatives
Patel, Meena V, Rohde, Jeffrey J, Gracias, Vijaya, Kolasa, Teodozyj
Published in Tetrahedron letters (25.08.2003)
Published in Tetrahedron letters (25.08.2003)
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Journal Article
1-Aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one Oximes as Potent Dopamine D4 Receptor Agonists for the Treatment of Erectile Dysfunction
Kolasa, Teodozyj, Matulenko, Mark A, Hakeem, Ahmed A, Patel, Meena V, Mortell, Kathleen, Bhatia, Pramila, Henry, Rodger, Nakane, Masaki, Hsieh, Gin C, Terranova, Marc A, Uchic, Marie E, Miller, Loan N, Chang, Renje, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Martino, Brenda, El Kouhen, Odile, Marsh, Kennan C, Wetter, Jill M, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O
Published in Journal of medicinal chemistry (24.08.2006)
Published in Journal of medicinal chemistry (24.08.2006)
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Journal Article
Synthesis of 4,5-Diaryl-1 H -pyrazole-3-ol Derivatives as Potential COX-2 Inhibitors
Patel, Meena V., Bell, Randy, Majest, Sandra, Henry, Rodger, Kolasa, Teodozyj
Published in Journal of organic chemistry (01.10.2004)
Published in Journal of organic chemistry (01.10.2004)
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Journal Article
A concise synthesis of ortho-substituted aryl-acrylamides—potent activators of soluble guanylyl cyclase
Zhang, Henry Q., Xia, Zhiren, Kolasa, Teodozyj, Dinges, Jurgen
Published in Tetrahedron letters (24.11.2003)
Published in Tetrahedron letters (24.11.2003)
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Journal Article
SUBSTITUTED BENZAMIDES AS CANNABINOID RECEPTOR LIGANDS
FROST JENNIFER M, PATEL MEENA, DART MICHAEL J, KOLASA TEODOZYJ, LIU BO, WANG XUEQING, PEREZ MEDRANO ARTURO, LATSHAW STEVEN P, PEDDI SRIDHAR, LI TONGMEI, NELSON DEREK W, CARROLL WILLIAM A
Year of Publication 09.06.2011
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Year of Publication 09.06.2011
Patent
A-315456: a selective α1D-adrenoceptor antagonist with minimal dopamine D2 and 5-HT1A receptor affinity
BUCKNER, Steven A, MILICIC, Ivan, DAZA, Anthony, LYNCH, James J, KOLASA, Teodozyj, NAKANE, Masaki, SULLIVAN, James P, BRIONI, Jorge D
Published in European journal of pharmacology (14.12.2001)
Published in European journal of pharmacology (14.12.2001)
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Journal Article
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist
Altenbach, RJ, Khilevich, A, Kolasa, T, Rohde, JJ, Bhatia, PA, Patel, MV, Searle, XB, Yang, F, Bunnelle, WH, Tietje, K, Bayburt, EK, Carroll, WA, Meyer, MD, Henry, R, Buckner, SA, Kuk, J, Daza, AV, Milicic, Cain, JC, Kang, CH, Ireland, LM, Carr, TL, Miller, TR, Hancock, AA, Nakane, M, Esbenshade, TA, Brune, ME, O'Neill, AB, Gauvin, DM, Katwala, SP, Holladay, MW, Brioni, JD, Sullivan, JP
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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