Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model
Chen, Chih-Ming, He, Yupeng, Lu, Liangjun, Lim, Hock Ben, Tripathi, Rakesh L, Middleton, Tim, Hernandez, Lisa E, Beno, David W A, Long, Michelle A, Kati, Warren M, Bosse, Todd D, Larson, Daniel P, Wagner, Rolf, Lanford, Robert E, Kohlbrenner, William E, Kempf, Dale J, Pilot-Matias, Tami J, Molla, Akhteruzzaman
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Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S2′ Pocket
Hidaka, Koushi, Kimura, Tooru, Abdel-Rahman, Hamdy M, Nguyen, Jeffrey-Tri, McDaniel, Keith F, Kohlbrenner, William E, Molla, Akhteruzzaman, Adachi, Motoyasu, Tamada, Taro, Kuroki, Ryota, Katsuki, Noriko, Tanaka, Yoshiaki, Matsumoto, Hikaru, Wang, Jun, Hayashi, Yoshio, Kempf, Dale J, Kiso, Yoshiaki
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Selection and Characterization of Varicella-Zoster Virus Variants Resistant to (R)-9-[4-Hydroxy-2-(Hydroxymethy)Butyl]Guanine
Ng, T I, Shi, Y, Huffaker, H J, Kati, W, Liu, Y, Chen, C M, Lin, Z, Maring, C, Kohlbrenner, W E, Molla, A
Published in Antimicrobial Agents and Chemotherapy (01.06.2001)
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Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol
Kempf, Dale J, Codacovi, Lynnmarie, Wang, Xiu Chun, Kohlbrenner, William E, Wideburg, Norman E, Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C, Bryant, Pamela
Published in Journal of medicinal chemistry (01.02.1993)
Published in Journal of medicinal chemistry (01.02.1993)
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New Quinolone Compounds from Pseudonocardia sp. with Selective and Potent Anti-Helicobacter pylori Activity: Taxonomy of Producing Strain, Fermentation, Isolation, Structural Elucidation and Biological Activities
DEKKER, KOEN A., INAGAKI, TAISUKE, GOOTZ, THOMAS D., HUANG, LIANG H., KOJIMA, YASUHIRO, KOHLBRENNER, WILLIAM E., MATSUNAGA, YASUE, MCGUIRK, PAUL R., NOMURA, ETSUKO, SAKAKIBARA, TATSUO, SAKEMI, SHINICHI, SUZUKI, YUMIKO, YAMAUCHI, YUJI, KOJIMA, NAKAO
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Published in Journal of antibiotics (01.02.1998)
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Structure-Based Characterization and Optimization of Novel Hydrophobic Binding Interactions in a Series of Pyrrolidine Influenza Neuraminidase Inhibitors
Maring, Clarence J, Stoll, Vincent S, Zhao, Chen, Sun, Minghua, Krueger, Allan C, Stewart, Kent D, Madigan, Darold L, Kati, Warren M, Xu, Yibo, Carrick, Robert J, Montgomery, Debra A, Kempf-Grote, Anita, Marsh, Kennan C, Molla, Akhteruzzaman, Steffy, Kevin R, Sham, Hing L, Laver, W. Graeme, Gu, Yu-gui, Kempf, Dale J, Kohlbrenner, William E
Published in Journal of medicinal chemistry (16.06.2005)
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Cationic lipids percentage and processing temperature are critical in designing siRNA lipid nanoparticles
Zhao, Xiaobin, Liu, Yemin, Song, Jingfeng, Yong, Hong, Li, Leiming, Shen, Yu, Hubbard, Robert D., Kohlbrenner, William E., Zhou, Ji, Cluff, Kevin D., Skoug, John W.
Published in Journal of drug targeting (01.04.2012)
Published in Journal of drug targeting (01.04.2012)
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Synthesis of potent pyrrolidine influenza neuraminidase inhibitors
Krueger, A. Chris, Xu, Yibo, Kati, Warren M., Kempf, Dale J., Maring, Clarence J., McDaniel, Keith F., Molla, Akhteruzzaman, Montgomery, Debra, Kohlbrenner, William E.
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 Variants with Increased Resistance to ABT-378, a Novel Protease Inhibitor
Carrillo, A, Stewart, K D, Sham, H L, Norbeck, D W, Kohlbrenner, W E, Leonard, J M, Kempf, D J, Molla, A
Published in Journal of Virology (01.09.1998)
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Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives
Hutchinson, Douglas K., Rosenberg, Teresa, Klein, Larry L., Bosse, Todd D., Larson, Daniel P., He, Wenping, Jiang, Wen W., Kati, Warren M., Kohlbrenner, William E., Liu, Yaya, Masse, Sherie V., Middleton, Tim, Molla, Akhteruzzaman, Montgomery, Debra A., Beno, David W.A., Stewart, Kent D., Stoll, Vincent S., Kempf, Dale J.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Inhibition of human immunodeficiency virus type I integrase by naphthamidines and 2-aminobenzimidazoles
Middleton, Tim, Lim, Hock B., Montgomery, Debra, Rockway, Todd, Tang, Hua, Cheng, Xueheng, Lu, Liangjun, Mo, Hongmei, Kohlbrenner, William E., Molla, Akhteruzzaman, Kati, Warren M.
Published in Antiviral research (01.10.2004)
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Structure-based, C2 symmetric inhibitors of HIV protease
Kempf, Dale J, Norbeck, Daniel W, Codacovi, LynnMarie, Wang, Xiu Chun, Kohlbrenner, William E, Wideburg, Norman E, Paul, Deborah A, Knigge, Mark F, Vasavanonda, Sudthida
Published in Journal of medicinal chemistry (01.10.1990)
Published in Journal of medicinal chemistry (01.10.1990)
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Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S-2 ' Pocket
Hidaka, Koushi, Kimura, Tooru, Abdel-Rahman, Hamdy M., Nguyen, Jeffrey-Tri, McDaniel, Keith F., Kohlbrenner, William E., Molla, Akhteruzzaman, Adachi, Motoyasu, Tamada, Taro, Kuroki, Ryota, Katsuki, Noriko, Tanaka, Yoshiaki, Matsumoto, Hikaru, Wang, Jun, Hayashi, Yoshio, Kempf, Dale J., Kiso, Yoshiaki
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
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Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
Erickson, J, Neidhart, D J, VanDrie, J, Kempf, D J, Wang, X C, Norbeck, D W, Plattner, J J, Rittenhouse, J W, Turon, M, Wideburg, N
Published in Science (American Association for the Advancement of Science) (03.08.1990)
Published in Science (American Association for the Advancement of Science) (03.08.1990)
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GS4071 Is a Slow-Binding Inhibitor of Influenza Neuraminidase from Both A and B Strains
Kati, Warren M., Saldivar, Ayda S., Mohamadi, Fariborz, Sham, Hing L., Laver, W.Graeme, Kohlbrenner, William E.
Published in Biochemical and biophysical research communications (17.03.1998)
Published in Biochemical and biophysical research communications (17.03.1998)
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Synthesis of (2S,5S,4R)-2,5-diamino-3,3-difluoro-1,6-diphenylhydroxyhexane : the core unit of a potent HIV proteinase inhibitor
SHAM, H. L, WIDEBURG, N. E, SPANTON, S. G, KOHLBRENNER, W. E, BETEBENNER, D. A, KEMPF, D. J, NORBECK, D. W, PLATTNER, J. J, ERICKSON, J. W
Published in Journal of the Chemical Society. Chemical communications (1991)
Published in Journal of the Chemical Society. Chemical communications (1991)
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Design of orally bioavailable, symmetry-based inhibitors of HIV protease
Kempf, Dale J., Marsh, Kennan C., Fino, Lynnmarie Codacovi, Bryant, Pamela, Craig-Kennard, Adrienne, Sham, Hing L., Zhao, Chen, Vasavanonda, Sudthida, Kohlbrenner, William E., Wideburg, Norman E., Saldivar, Ayda, Green, Brian E., Herrin, Thomas, Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry (01.09.1994)
Published in Bioorganic & medicinal chemistry (01.09.1994)
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Affinity purification of HIV-1 and HIV-2 proteases from recombinant E. coli strains using pepstatin-agarose
Rittenhouse, Judith, Turon, Mary C., Helfrich, Rosalind J., Albrecht, Kathryn S., Weigl, Debra, Simmer, Robert L., Mordini, Federico, Erickson, John, Kohlbrenner, William E.
Published in Biochemical and biophysical research communications (31.08.1990)
Published in Biochemical and biophysical research communications (31.08.1990)
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High-level expression and purification of mature HIV-1 protease in Escherichia coli under control of the araBAD promoter
Taylor, A, Brown, D P, Kadam, S, Maus, M, Kohlbrenner, W E, Weigl, D, Turon, M C, Katz, L
Published in Applied microbiology and biotechnology (01.05.1992)
Published in Applied microbiology and biotechnology (01.05.1992)
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