Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
Theriot, Casey M., Koenigsknecht, Mark J., Carlson, Paul E., Hatton, Gabrielle E., Nelson, Adam M., Li, Bo, Huffnagle, Gary B., Z. Li, Jun, Young, Vincent B.
Published in Nature communications (01.01.2014)
Published in Nature communications (01.01.2014)
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Suppression of Clostridium difficile in the Gastrointestinal Tracts of Germfree Mice Inoculated with a Murine Isolate from the Family Lachnospiraceae
REEVES, Angela E, KOENIGSKNECHT, Mark J, BERGIN, Ingrid L, YOUNG, Vincent B
Published in Infection and Immunity (01.11.2012)
Published in Infection and Immunity (01.11.2012)
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NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth
Chen, Liang, Wilson, Justin E, Koenigsknecht, Mark J, Chou, Wei-Chun, Montgomery, Stephanie A, Truax, Agnieszka D, Brickey, W June, Packey, Christopher D, Maharshak, Nitsan, Matsushima, Glenn K, Plevy, Scott E, Young, Vincent B, Sartor, R Balfour, Ting, Jenny P-Y
Published in Nature immunology (01.05.2017)
Published in Nature immunology (01.05.2017)
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The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis
Truax, Agnieszka D., Chen, Liang, Tam, Jason W., Cheng, Ning, Guo, Hao, Koblansky, A. Alicia, Chou, Wei-Chun, Wilson, Justin E., Brickey, W. June, Petrucelli, Alex, Liu, Rongrong, Cooper, Daniel E., Koenigsknecht, Mark J., Young, Vincent B., Netea, Mihai G., Stienstra, Rinke, Sartor, R. Balfour, Montgomery, Stephanie A., Coleman, Rosalind A., Ting, Jenny P.-Y.
Published in Cell host & microbe (12.09.2018)
Published in Cell host & microbe (12.09.2018)
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Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease
Mathewson, Nathan D, Jenq, Robert, Mathew, Anna V, Koenigsknecht, Mark, Hanash, Alan, Toubai, Tomomi, Oravecz-Wilson, Katherine, Wu, Shin-Rong, Sun, Yaping, Rossi, Corinne, Fujiwara, Hideaki, Byun, Jaeman, Shono, Yusuke, Lindemans, Caroline, Calafiore, Marco, Schmidt, Thomas M, Honda, Kenya, Young, Vincent B, Pennathur, Subramaniam, van den Brink, Marcel, Reddy, Pavan
Published in Nature immunology (01.05.2016)
Published in Nature immunology (01.05.2016)
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Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs
Hens, Bart, Tsume, Yasuhiro, Bermejo, Marival, Paixao, Paulo, Koenigsknecht, Mark J, Baker, Jason R, Hasler, William L, Lionberger, Robert, Fan, Jianghong, Dickens, Joseph, Shedden, Kerby, Wen, Bo, Wysocki, Jeffrey, Loebenberg, Raimar, Lee, Allen, Frances, Ann, Amidon, Greg, Yu, Alex, Benninghoff, Gail, Salehi, Niloufar, Talattof, Arjang, Sun, Duxin, Amidon, Gordon L
Published in Molecular pharmaceutics (04.12.2017)
Published in Molecular pharmaceutics (04.12.2017)
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In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions
Koenigsknecht, Mark J, Baker, Jason R, Wen, Bo, Frances, Ann, Zhang, Huixia, Yu, Alex, Zhao, Ting, Tsume, Yasuhiro, Pai, Manjunath P, Bleske, Barry E, Zhang, Xinyuan, Lionberger, Robert, Lee, Allen, Amidon, Gordon L, Hasler, William L, Sun, Duxin
Published in Molecular pharmaceutics (04.12.2017)
Published in Molecular pharmaceutics (04.12.2017)
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Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract
Yu, Alex, Baker, Jason R, Fioritto, Ann F, Wang, Ying, Luo, Ruijuan, Li, Siwei, Wen, Bo, Bly, Michael, Tsume, Yasuhiro, Koenigsknecht, Mark J, Zhang, Xinyuan, Lionberger, Robert, Amidon, Gordon L, Hasler, William L, Sun, Duxin
Published in Molecular pharmaceutics (06.02.2017)
Published in Molecular pharmaceutics (06.02.2017)
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Spatial and Temporal Analysis of the Stomach and Small-Intestinal Microbiota in Fasted Healthy Humans
Seekatz, Anna M, Schnizlein, Matthew K, Koenigsknecht, Mark J, Baker, Jason R, Hasler, William L, Bleske, Barry E, Young, Vincent B, Sun, Duxin
Published in mSphere (13.03.2019)
Published in mSphere (13.03.2019)
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Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach
Paixão, Paulo, Bermejo, Marival, Hens, Bart, Tsume, Yasuhiro, Dickens, Joseph, Shedden, Kerby, Salehi, Niloufar, Koenigsknecht, Mark J., Baker, Jason R., Hasler, William L., Lionberger, Robert, Fan, Jianghong, Wysocki, Jeffrey, Wen, Bo, Lee, Allen, Frances, Ann, Amidon, Gregory E., Yu, Alex, Benninghoff, Gail, Löbenberg, Raimar, Talattof, Arjang, Sun, Duxin, Amidon, Gordon L.
Published in European journal of pharmaceutics and biopharmaceutics (01.08.2018)
Published in European journal of pharmaceutics and biopharmaceutics (01.08.2018)
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Mechanistic Deconvolution of Oral Absorption Model with Dynamic Gastrointestinal Fluid to Predict Regional Rate and Extent of GI Drug Dissolution
Yu, Alex, Koenigsknecht, Mark J., Hens, Bart, Baker, Jason R., Wen, Bo, Jackson, Trachette L., Pai, Manjunath P., Hasler, William, Amidon, Gordon L., Sun, Duxin
Published in The AAPS journal (11.11.2019)
Published in The AAPS journal (11.11.2019)
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The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation
Dahl, Jan-Ulrik, Gray, Michael J., Bazopoulou, Daphne, Beaufay, Francois, Lempart, Justine, Koenigsknecht, Mark J., Wang, Ying, Baker, Jason R., Hasler, William L., Young, Vincent B., Sun, Duxin, Jakob, Ursula
Published in Nature microbiology (23.01.2017)
Published in Nature microbiology (23.01.2017)
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Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within HumansPart 1: Fasted State Conditions
Bermejo, Marival, Paixão, Paulo, Hens, Bart, Tsume, Yasuhiro, Koenigsknecht, Mark J., Baker, Jason R., Hasler, William L., Lionberger, Robert, Fan, Jianghong, Dickens, Joseph, Shedden, Kerby, Wen, Bo, Wysocki, Jeffrey, Löbenberg, Raimar, Lee, Allen, Frances, Ann, Amidon, Gregory E., Yu, Alex, Salehi, Niloufar, Talattof, Arjang, Benninghoff, Gail, Sun, Duxin, Kuminek, Gislaine, Cavanagh, Katie L., Rodríguez-Hornedo, Naír, Amidon, Gordon L.
Published in Molecular pharmaceutics (03.12.2018)
Published in Molecular pharmaceutics (03.12.2018)
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Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time
Yu, Alex, Jackson, Trachette, Tsume, Yasuhiro, Koenigsknecht, Mark, Wysocki, Jeffrey, Marciani, Luca, Amidon, Gordon L., Frances, Ann, Baker, Jason R., Hasler, William, Wen, Bo, Pai, Amit, Sun, Duxin
Published in The AAPS journal (01.11.2017)
Published in The AAPS journal (01.11.2017)
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Journal Article
Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within HumansPart 2: Fed State
Paixão, Paulo, Bermejo, Marival, Hens, Bart, Tsume, Yasuhiro, Dickens, Joseph, Shedden, Kerby, Salehi, Niloufar, Koenigsknecht, Mark J., Baker, Jason R., Hasler, William L., Lionberger, Robert, Fan, Jianghong, Wysocki, Jeffrey, Wen, Bo, Lee, Allen, Frances, Ann, Amidon, Gregory E., Yu, Alex, Benninghoff, Gail, Löbenberg, Raimar, Talattof, Arjang, Sun, Duxin, Amidon, Gordon L.
Published in Molecular pharmaceutics (03.12.2018)
Published in Molecular pharmaceutics (03.12.2018)
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Thiamine biosynthesis can be used to dissect metabolic integration
Koenigsknecht, Mark J, Downs, Diana M
Published in Trends in microbiology (Regular ed.) (01.06.2010)
Published in Trends in microbiology (Regular ed.) (01.06.2010)
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Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica
Koenigsknecht, Mark J, Lambrecht, Jennifer A, Fenlon, Luke A, Downs, Diana M
Published in PloS one (25.10.2012)
Published in PloS one (25.10.2012)
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The Essential GTPase YqeH Is Required for Proper Ribosome Assembly in Bacillus subtilis
UICKER, William C, SCHAEFER, Laura, KOENIGSKNECHT, Mark, BRITTON, Robert A
Published in Journal of Bacteriology (01.04.2007)
Published in Journal of Bacteriology (01.04.2007)
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