Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
Zoppi, Vittoria, Hughes, Scott J, Maniaci, Chiara, Testa, Andrea, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin M, Daniels, Danette L, Spallarossa, Andrea, Ciulli, Alessio
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
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Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2019)
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A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
Kofink, Christiane, Trainor, Nicole, Mair, Barbara, Wöhrle, Simon, Wurm, Melanie, Mischerikow, Nikolai, Roy, Michael J., Bader, Gerd, Greb, Peter, Garavel, Géraldine, Diers, Emelyne, McLennan, Ross, Whitworth, Claire, Vetma, Vesna, Rumpel, Klaus, Scharnweber, Maximilian, Fuchs, Julian E., Gerstberger, Thomas, Cui, Yunhai, Gremel, Gabriela, Chetta, Paolo, Hopf, Stefan, Budano, Nicole, Rinnenthal, Joerg, Gmaschitz, Gerhard, Mayer, Moriz, Koegl, Manfred, Ciulli, Alessio, Weinstabl, Harald, Farnaby, William
Published in Nature communications (10.10.2022)
Published in Nature communications (10.10.2022)
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Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
Martin, Laetitia J, Koegl, Manfred, Bader, Gerd, Cockcroft, Xiao-Ling, Fedorov, Oleg, Fiegen, Dennis, Gerstberger, Thomas, Hofmann, Marco H, Hohmann, Anja F, Kessler, Dirk, Knapp, Stefan, Knesl, Petr, Kornigg, Stefan, Müller, Susanne, Nar, Herbert, Rogers, Catherine, Rumpel, Klaus, Schaaf, Otmar, Steurer, Steffen, Tallant, Cynthia, Vakoc, Christopher R, Zeeb, Markus, Zoephel, Andreas, Pearson, Mark, Boehmelt, Guido, McConnell, Darryl
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication
Griffiths, Samantha J, Koegl, Manfred, Boutell, Chris, Zenner, Helen L, Crump, Colin M, Pica, Francesca, Gonzalez, Orland, Friedel, Caroline C, Barry, Gerald, Martin, Kim, Craigon, Marie H, Chen, Rui, Kaza, Lakshmi N, Fossum, Even, Fazakerley, John K, Efstathiou, Stacey, Volpi, Antonio, Zimmer, Ralf, Ghazal, Peter, Haas, Jürgen
Published in PLoS pathogens (01.08.2013)
Published in PLoS pathogens (01.08.2013)
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Evolutionarily conserved herpesviral protein interaction networks
Fossum, Even, Friedel, Caroline C, Rajagopala, Seesandra V, Titz, Björn, Baiker, Armin, Schmidt, Tina, Kraus, Theo, Stellberger, Thorsten, Rutenberg, Christiane, Suthram, Silpa, Bandyopadhyay, Sourav, Rose, Dietlind, von Brunn, Albrecht, Uhlmann, Mareike, Zeretzke, Christine, Dong, Yu-An, Boulet, Hélène, Koegl, Manfred, Bailer, Susanne M, Koszinowski, Ulrich, Ideker, Trey, Uetz, Peter, Zimmer, Ralf, Haas, Jürgen
Published in PLoS pathogens (01.09.2009)
Published in PLoS pathogens (01.09.2009)
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The EHEC-host interactome reveals novel targets for the translocated intimin receptor
Blasche, Sonja, Arens, Stefan, Ceol, Arnaud, Siszler, Gabriella, Schmidt, M. Alexander, Häuser, Roman, Schwarz, Frank, Wuchty, Stefan, Aloy, Patrick, Uetz, Peter, Stradal, Theresia, Koegl, Manfred
Published in Scientific reports (18.12.2014)
Published in Scientific reports (18.12.2014)
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A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly
Koegl, Manfred, Hoppe, Thorsten, Schlenker, Stephan, Ulrich, Helle D, Mayer, Thomas U, Jentsch, Stefan
Published in Cell (05.03.1999)
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Mitotic Arrest-Deficient 2 Like 2 (MAD2L2) Interacts with Escherichia coli Effector Protein EspF
Tahoun, Amin, El-Sharkawy, Hanem, Moustafa, Samar M., Abdel-Hafez, Lina Jamil M., Albrakati, Ashraf, Koegl, Manfred, Haas, Juergen, Mahajan, Arvind, Gally, David L., Elmahallawy, Ehab Kotb
Published in Life (Basel, Switzerland) (15.09.2021)
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Automated Yeast Two-hybrid Screening for Nuclear Receptor-interacting Proteins
Albers, Michael, Kranz, Harald, Kober, Ingo, Kaiser, Carmen, Klink, Martin, Suckow, Jörg, Kern, Rainer, Koegl, Manfred
Published in Molecular & cellular proteomics (01.02.2005)
Published in Molecular & cellular proteomics (01.02.2005)
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Comparative Analysis of EspF Variants in Inhibition of Escherichia coli Phagocytosis by Macrophages and Inhibition of E. coli Translocation through Human- and Bovine-Derived M Cells
TAHOUN, Amin, SISZLER, Gabriella, KOEGL, Manfred, HAAS, Juergen, GALLY, David L, MAHAJAN, Arvind, SPEARS, Kevin, MCATEER, Sean, TREE, Jai, PAXTON, Edith, GILLESPIE, Trudi L, MARTINEZ-ARGUDO, Isabel, JEPSON, Mark A, SHAW, Darren J
Published in Infection and Immunity (01.11.2011)
Published in Infection and Immunity (01.11.2011)
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Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol
Otte, Kerstin, Kranz, Harald, Kober, Ingo, Thompson, Paul, Hoefer, Michael, Haubold, Bernhard, Remmel, Bettina, Voss, Hartmut, Kaiser, Carmen, Albers, Michael, Cheruvallath, Zaccharias, Jackson, David, Casari, Georg, Koegl, Manfred, Pääbo, Svante, Mous, Jan, Kremoser, Claus, Deuschle, Ulrich
Published in Molecular and Cellular Biology (01.02.2003)
Published in Molecular and Cellular Biology (01.02.2003)
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A Community Standard Format for the Representation of Protein Affinity Reagents
Gloriam, David E., Orchard, Sandra, Bertinetti, Daniela, Björling, Erik, Bongcam-Rudloff, Erik, Borrebaeck, Carl A.K., Bourbeillon, Julie, Bradbury, Andrew R.M., de Daruvar, Antoine, Dübel, Stefan, Frank, Ronald, Gibson, Toby J., Gold, Larry, Haslam, Niall, Herberg, Friedrich W., Hiltke, Tara, Hoheisel, Jörg D., Kerrien, Samuel, Koegl, Manfred, Konthur, Zoltán, Korn, Bernhard, Landegren, Ulf, Montecchi-Palazzi, Luisa, Palcy, Sandrine, Rodriguez, Henry, Schweinsberg, Sonja, Sievert, Volker, Stoevesandt, Oda, Taussig, Michael J., Ueffing, Marius, Uhlén, Mathias, van der Maarel, Silvère, Wingren, Christer, Woollard, Peter, Sherman, David J., Hermjakob, Henning
Published in Molecular & cellular proteomics (01.01.2010)
Published in Molecular & cellular proteomics (01.01.2010)
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Sequence Requirements for Binding of Src Family Tyrosine Kinases to Activated Growth Factor Receptors
Alonso, G, Koegl, M, Mazurenko, N, Courtneidge, S A
Published in The Journal of biological chemistry (28.04.1995)
Published in The Journal of biological chemistry (28.04.1995)
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Elucidation of an Archaeal Replication Protein Network to Generate Enhanced PCR Enzymes
Motz, Michael, Kober, Ingo, Girardot, Charles, Loeser, Eva, Bauer, Ulrike, Albers, Michael, Moeckel, Gerd, Minch, Eric, Voss, Hartmut, Kilger, Christian, Koegl, Manfred
Published in The Journal of biological chemistry (03.05.2002)
Published in The Journal of biological chemistry (03.05.2002)
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Computer-Assisted Generation of a Protein-Interaction Database for Nuclear Receptors
Albert, Sylvie, Gaudan, Sylvain, Knigge, Heidrun, Raetsch, Andreas, Delgado, Asuncion, Huhse, Bettina, Kirsch, Harald, Albers, Michael, Rebholz-Schuhmann, Dietrich, Koegl, Manfred
Published in Molecular endocrinology (Baltimore, Md.) (01.08.2003)
Published in Molecular endocrinology (Baltimore, Md.) (01.08.2003)
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Transforming targeted cancer therapy with PROTACs: A forward-looking perspective
Farnaby, William, Koegl, Manfred, McConnell, Darryl B., Ciulli, Alessio
Published in Current opinion in pharmacology (01.04.2021)
Published in Current opinion in pharmacology (01.04.2021)
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A Novel Principle for Partial Agonism of Liver X Receptor Ligands
Albers, Michael, Blume, Beatrix, Schlueter, Thomas, Wright, Matthew B., Kober, Ingo, Kremoser, Claus, Deuschle, Ulrich, Koegl, Manfred
Published in The Journal of biological chemistry (24.02.2006)
Published in The Journal of biological chemistry (24.02.2006)
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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio
Published in Nature chemical biology (01.07.2019)
Published in Nature chemical biology (01.07.2019)
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Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions
Popow, Johannes, Arnhof, Heribert, Bader, Gerd, Berger, Helmut, Ciulli, Alessio, Covini, David, Dank, Christian, Gmaschitz, Teresa, Greb, Peter, Karolyi-Özguer, Jale, Koegl, Manfred, McConnell, Darryl B, Pearson, Mark, Rieger, Maria, Rinnenthal, Joerg, Roessler, Vanessa, Schrenk, Andreas, Spina, Markus, Steurer, Steffen, Trainor, Nicole, Traxler, Elisabeth, Wieshofer, Corinna, Zoephel, Andreas, Ettmayer, Peter
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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