Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone
Kodaira, Hiroshi, Kusuhara, Hiroyuki, Ushiki, Junko, Fuse, Eiichi, Sugiyama, Yuichi
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
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Journal Article
Targeted delivery to macrophages and dendritic cells by chemically modified mannose ligand-conjugated siRNA
Uehara, Keiji, Harumoto, Toshimasa, Makino, Asana, Koda, Yasuo, Iwano, Junko, Suzuki, Yasuhiro, Tanigawa, Mari, Iwai, Hiroto, Asano, Kana, Kurihara, Kana, Hamaguchi, Akinori, Kodaira, Hiroshi, Atsumi, Toshiyuki, Yamada, Yoji, Tomizuka, Kazuma
Published in Nucleic acids research (20.05.2022)
Published in Nucleic acids research (20.05.2022)
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Journal Article
Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate
Kodaira, Hiroshi, Kusuhara, Hiroyuki, Fujita, Takuya, Ushiki, Junko, Fuse, Eiichi, Sugiyama, Yuichi
Published in The Journal of pharmacology and experimental therapeutics (01.12.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2011)
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Journal Article
The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis
Fujisawa, Takao, Takahashi, Motoo, Tsukamoto, Yuka, Yamaguchi, Namiko, Nakoji, Masayoshi, Endo, Megumi, Kodaira, Hiroshi, Hayashi, Yuki, Nishitoh, Hideki, Naguro, Isao, Homma, Kengo, Ichijo, Hidenori
Published in Human molecular genetics (15.01.2016)
Published in Human molecular genetics (15.01.2016)
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Journal Article
Quantitative investigation of the brain-to-cerebrospinal fluid unbound drug concentration ratio under steady-state conditions in rats using a pharmacokinetic model and scaling factors for active efflux transporters
Kodaira, Hiroshi, Kusuhara, Hiroyuki, Fuse, Eiichi, Ushiki, Junko, Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.06.2014)
Published in Drug metabolism and disposition (01.06.2014)
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Journal Article
Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan
Tamaki, Chihiro, Nagayama, Takashi, Hashiba, Masamichi, Fujiyoshi, Masato, Hizue, Masanori, Kodaira, Hiroshi, Nishida, Minoru, Suzuki, Kazuhiko, Takashima, Yoshiharu, Ogino, Yamato, Yasugi, Daisaku, Yoneta, Yasuo, Hisada, Shigeru, Ohkura, Takako, Nakamura, Kazuichi
Published in Journal of toxicological sciences (2013)
Published in Journal of toxicological sciences (2013)
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Journal Article
Heat stroke management during the COVID‐19 pandemic: Recommendations from the experts in Japan (2nd edition)
Kanda, Jun, Wakasugi, Masahiro, Kondo, Yutaka, Ueno, Satoru, Kaneko, Hitoshi, Okada, Yohei, Okano, Yuichi, Kishihara, Yuki, Hamaguchi, Jun, Ishihara, Tadashi, Igarashi, Yutaka, Nakae, Ryuta, Miyamoto, Sohma, Yamada, Eri, Ikechi, Daisuke, Yamazaki, Maiko, Tanaka, Daiki, Sawada, Yusuke, Suda, Chiaki, Yoshimura, Satoshi, Onodera, Ryuta, Kano, Kenichi, Hongo, Takashi, Endo, Kaori, Iwasaki, Yohei, Kodaira, Hiroshi, Yasuo, Shunsuke, Seki, Nozomu, Okuda, Hiroshi, Nakajima, Satoshi, Nagato, Tadashi, Terazumi, Keiko, Nakamura, Satoshi, Yokobori, Shoji
Published in Acute medicine & surgery (01.01.2023)
Published in Acute medicine & surgery (01.01.2023)
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Journal Article
Low-dose immunoglobulin G is not associated with mortality in patients with sepsis and septic shock
Iizuka, Yusuke, Sanui, Masamitsu, Sasabuchi, Yusuke, Lefor, Alan Kawarai, Hayakawa, Mineji, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, Kudo, Daisuke, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, Hori, Naoto
Published in Critical care (London, England) (13.07.2017)
Published in Critical care (London, England) (13.07.2017)
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Journal Article
The use of PVP as a polymeric carrier to improve the plasma half-life of drugs
Kaneda, Yoshihisa, Tsutsumi, Yasuo, Yoshioka, Yasuo, Kamada, Haruhiko, Yamamoto, Yoko, Kodaira, Hiroshi, Tsunoda, Shin-ichi, Okamoto, Takayuki, Mukai, Yohei, Shibata, Hiroko, Nakagawa, Shinsaku, Mayumi, Tadanori
Published in Biomaterials (01.07.2004)
Published in Biomaterials (01.07.2004)
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Journal Article
Abstract 5534: A novel and oral histone deacetylase inhibitor, resminostat, effectively suppresses the growth of non-small cell lung cancer in a xenograft mouse model
Takagi, Akimitsu, Konishi, Hiroaki, Tsugane, Momomi, Taniguchi, Keisuke, Takahashi, Hiroyuki, Inutake, Yu, Watanabe, Akinobu, Kodaira, Hiroshi, Matsuzaki, Takeshi
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011-2013
Hayakawa, Mineji, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, Hori, Naoto
Published in Journal of intensive care (12.07.2016)
Published in Journal of intensive care (12.07.2016)
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Journal Article
The targeting of anionized polyvinylpyrrolidone to the renal system
Kodaira, Hiroshi, Tsutsumi, Yasuo, Yoshioka, Yasuo, Kamada, Haruhiko, Kaneda, Yoshihisa, Yamamoto, Yoko, Tsunoda, Shin-ichi, Okamoto, Takayuki, Mukai, Yohei, Shibata, Hiroko, Nakagawa, Shinsaku, Mayumi, Tadanori
Published in Biomaterials (01.08.2004)
Published in Biomaterials (01.08.2004)
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Journal Article
Design of a pH-Sensitive Polymeric Carrier for Drug Release and Its Application in Cancer Therapy
KAMADA, Haruhiko, TSUTSUMI, Yasuo, MAYUMI, Tadanori, YOSHIOKA, Yasuo, YAMAMOTO, Yoko, KODAIRA, Hiroshi, TSUNODA, Shin-Ichi, OKAMOTO, Takayuki, MUKAI, Yohei, SHIBATA, Hiroko, NAKAGAWA, Shinsaku
Published in Clinical cancer research (01.04.2004)
Published in Clinical cancer research (01.04.2004)
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