Synthesis and Evaluation of in Vivo Anti-hypothermic Effect of the N- and C-Terminus Modified Thyrotropin-Releasing Hormone Mimetic: [(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-[3-(thiazol-4-yl)-L-alanyl]-L-prolinamide
Kobayashi, Naotake, Sato, Norihito, Sugita, Katsuji, Kihara, Tsuyoshi, Koike, Katsumi, Sugawara, Tamio, Tada, Yukio, Yoshikawa, Takayoshi
Published in Chemical & pharmaceutical bulletin (01.04.2021)
Published in Chemical & pharmaceutical bulletin (01.04.2021)
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Journal Article
Synthesis and evaluation of in vivo anti‐hypothermic effect of all stereoisomers of the thyrotropin‐releasing hormone mimetic: Rovatirelin Hydrate
Kobayashi, Naotake, Sato, Norihito, Sugita, Katsuji, Takahashi, Kouji, Sugawara, Tamio, Tada, Yukio, Yoshikawa, Takayoshi
Published in Journal of peptide science (01.12.2019)
Published in Journal of peptide science (01.12.2019)
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Journal Article
Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1‑{N‑[(4S,5S)‑(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)‑l‑alanyl}-(2R)‑2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)
Kobayashi, Naotake, Sato, Norihito, Fujimura, Yuko, Kihara, Tsuyoshi, Sugita, Katsuji, Takahashi, Kouji, Koike, Katsumi, Sugawara, Tamio, Tada, Yukio, Nakai, Hiroshi, Yoshikawa, Takayoshi
Published in ACS omega (31.10.2018)
Published in ACS omega (31.10.2018)
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Journal Article
Correction to Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1‑{N‑[(4S,5S)‑(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)‑l‑alanyl}-(2R)‑2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate)
Kobayashi, Naotake, Sato, Norihito, Fujimura, Yuko, Kihara, Tsuyoshi, Sugita, Katsuji, Takahashi, Kouji, Koike, Katsumi, Sugawara, Tamio, Tada, Yukio, Nakai, Hiroshi, Yoshikawa, Takayoshi
Published in ACS omega (30.04.2019)
Published in ACS omega (30.04.2019)
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Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy
Nishiura, Yuji, Matsumura, Akira, Kobayashi, Naotake, Shimazaki, Atsuyuki, Sakamoto, Shingo, Kitade, Naohisa, Tonomura, Yutaka, Ino, Akira, Okuno, Takayuki
Published in Bioorganic & medicinal chemistry letters (01.08.2018)
Published in Bioorganic & medicinal chemistry letters (01.08.2018)
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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening
Tobinaga, Hiroyuki, Kameyama, Takayuki, Oohara, Miho, Kobayashi, Naotake, Ohdan, Masahide, Ishizuka, Natsuki, Kume, Masaharu, Tomari, Maki, Tanaka, Yoshikazu, Takahashi, Fumiyo, Kinoshita, Haruki, Shimada, Shinji, Shinohara, Shunji, Kai, Hiroyuki
Published in Bioorganic & medicinal chemistry letters (15.07.2018)
Published in Bioorganic & medicinal chemistry letters (15.07.2018)
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BICYCLIC HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
KUDO, Hiromi, NAKAHASHI, Atsufumi, ICHIHASHI, Yusuke, KOBAYASHI, Naotake, KUROSE, Noriyuki
Year of Publication 07.12.2017
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Year of Publication 07.12.2017
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PHARMACEUTICAL COMPOSITION CONTAINING BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE
SUGIYAMA SHUICHI, OGAWA TOMOYUKI, KOJIMA EIICHI, KAI HIROYUKI, MASUDA KOJI, YAMADA TORU, KOBAYASHI NAOTAKE
Year of Publication 24.10.2019
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Year of Publication 24.10.2019
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2환성 함질소 헤테로환 유도체 및 그를 함유하는 의약 조성물
SUGIYAMA SHUICHI, OGAWA TOMOYUKI, KOJIMA EIICHI, KAI HIROYUKI, MASUDA KOJI, YAMADA TORU, KOBAYASHI NAOTAKE
Year of Publication 31.05.2019
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Year of Publication 31.05.2019
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NOVEL ALKYLENE DERIVATIVE
OYABU NAOKI, MIYAZAKI KEISUKE, KURAHASHI KANA, URABE SATOMI, FUMOTO MASATAKA, IWATSU MASAFUMI, KOBAYASHI NAOTAKE, ASAHI KENTARO, TOMITA YUTAKA, ODAN MASAHIDE, SASAKI YOSHIKAZU, WADA TOSHIHIRO, KATO MANABU, NISHIURA YUJI, INOUE TAKATSUGU
Year of Publication 10.01.2019
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Year of Publication 10.01.2019
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NOVEL OLEFIN DERIVATIVE
KOBAYASHI, NAOTAKE, KIDA, SHIRO, MATSUMURA, AKIRA, YONEHARA, MITSUHIRO, NISHIURA, YUJI, TAGASHIRA, SACHIE, WATANABE, KANA
Year of Publication 14.03.2013
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Year of Publication 14.03.2013
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NOVEL ALKYLENE DERIVATIVE
KOBAYASHI, NAOTAKE, IWATSU, MASAFUMI, FUMOTO, MASATAKA, SASAKI, YOSHIKAZU, NISHIURA, YUJI, URABE, TOMOMI, ASAHI, KENTAROU, OHDAN, MASAHIDE, OHYABU, NAOKI, WADA, TOSHIHIRO, KURAHASHI, KANA, INOUE, TAKATSUGU, MIYAZAKI, KEISUKE, KATOU, MANABU, TOMIDA, YUTAKA
Year of Publication 23.04.2015
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Year of Publication 23.04.2015
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PIPERAZINE DERIVATIVE
TAZAWA, AYA, TOMIDA, MINORU, KOBAYASHI, NAOTAKE, HATA, KAYOKO, MASUI, MORIYASU, ANAN, KOUSUKE
Year of Publication 26.02.2009
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Year of Publication 26.02.2009
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