Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
Knutson, Sarah K., Warholic, Natalie M., Wigle, Tim J., Klaus, Christine R., Allain, Christina J., Raimondi, Alejandra, Scott, Margaret Porter, Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M., Kuntz, Kevin W., Keilhack, Heike
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
Sneeringer, Christopher J., Scott, Margaret Porter, Kuntz, Kevin W., Knutson, Sarah K., Pollock, Roy M., Richon, Victoria M., Copeland, Robert A., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (07.12.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (07.12.2010)
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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
Knutson, Sarah K, Kawano, Satoshi, Minoshima, Yukinori, Warholic, Natalie M, Huang, Kuan-Chun, Xiao, Yonghong, Kadowaki, Tadashi, Uesugi, Mai, Kuznetsov, Galina, Kumar, Namita, Wigle, Tim J, Klaus, Christine R, Allain, Christina J, Raimondi, Alejandra, Waters, Nigel J, Smith, Jesse J, Porter-Scott, Margaret, Chesworth, Richard, Moyer, Mikel P, Copeland, Robert A, Richon, Victoria M, Uenaka, Toshimitsu, Pollock, Roy M, Kuntz, Kevin W, Yokoi, Akira, Keilhack, Heike
Published in Molecular cancer therapeutics (01.04.2014)
Published in Molecular cancer therapeutics (01.04.2014)
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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
Knutson, Sarah K, Wigle, Tim J, Warholic, Natalie M, Sneeringer, Christopher J, Allain, Christina J, Klaus, Christine R, Sacks, Joelle D, Raimondi, Alejandra, Majer, Christina R, Song, Jeffrey, Scott, Margaret Porter, Jin, Lei, Smith, Jesse J, Olhava, Edward J, Chesworth, Richard, Moyer, Mikel P, Richon, Victoria M, Copeland, Robert A, Keilhack, Heike, Pollock, Roy M, Kuntz, Kevin W
Published in Nature chemical biology (01.11.2012)
Published in Nature chemical biology (01.11.2012)
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Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models
Chan-Penebre, Elayne, Armstrong, Kelli, Drew, Allison, Grassian, Alexandra R, Feldman, Igor, Knutson, Sarah K, Kuplast-Barr, Kristy, Roche, Maria, Campbell, John, Ho, Peter, Copeland, Robert A, Chesworth, Richard, Smith, Jesse J, Keilhack, Heike, Ribich, Scott A
Published in Molecular cancer therapeutics (01.05.2017)
Published in Molecular cancer therapeutics (01.05.2017)
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Loss of BAP1 function leads to EZH2-dependent transformation
LaFave, Lindsay M, Béguelin, Wendy, Koche, Richard, Teater, Matt, Spitzer, Barbara, Chramiec, Alan, Papalexi, Efthymia, Keller, Matthew D, Hricik, Todd, Konstantinoff, Katerina, Micol, Jean-Baptiste, Durham, Benjamin, Knutson, Sarah K, Campbell, John E, Blum, Gil, Shi, Xinxu, Doud, Emma H, Krivtsov, Andrei V, Chung, Young Rock, Khodos, Inna, de Stanchina, Elisa, Ouerfelli, Ouathek, Adusumilli, Prasad S, Thomas, Paul M, Kelleher, Neil L, Luo, Minkui, Keilhack, Heike, Abdel-Wahab, Omar, Melnick, Ari, Armstrong, Scott A, Levine, Ross L
Published in Nature medicine (01.11.2015)
Published in Nature medicine (01.11.2015)
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The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat
Kuntz, Kevin W, Campbell, John E, Keilhack, Heike, Pollock, Roy M, Knutson, Sarah K, Porter-Scott, Margaret, Richon, Victoria M, Sneeringer, Chris J, Wigle, Tim J, Allain, Christina J, Majer, Christina R, Moyer, Mikel P, Copeland, Robert A, Chesworth, Richard
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma
Kawano, Satoshi, Grassian, Alexandra R, Tsuda, Masumi, Knutson, Sarah K, Warholic, Natalie M, Kuznetsov, Galina, Xu, Shanqin, Xiao, Yonghong, Pollock, Roy M, Smith, Jesse S, Kuntz, Kevin K, Ribich, Scott, Minoshima, Yukinori, Matsui, Junji, Copeland, Robert A, Tanaka, Shinya, Keilhack, Heike
Published in PloS one (08.07.2016)
Published in PloS one (08.07.2016)
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Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability
Bhaskara, Srividya, Knutson, Sarah K., Jiang, Guochun, Chandrasekharan, Mahesh B., Wilson, Andrew J., Zheng, Siyuan, Yenamandra, Ashwini, Locke, Kimberly, Yuan, Jia-ling, Bonine-Summers, Alyssa R., Wells, Christina E., Kaiser, Jonathan F., Washington, M. Kay, Zhao, Zhongming, Wagner, Florence F., Sun, Zu-Wen, Xia, Fen, Holson, Edward B., Khabele, Dineo, Hiebert, Scott W.
Published in Cancer cell (16.11.2010)
Published in Cancer cell (16.11.2010)
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EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL
Brach, Dorothy, Johnston-Blackwell, Danielle, Drew, Allison, Lingaraj, Trupti, Motwani, Vinny, Warholic, Natalie M, Feldman, Igor, Plescia, Christopher, Smith, Jesse J, Copeland, Robert A, Keilhack, Heike, Chan-Penebre, Elayne, Knutson, Sarah K, Ribich, Scott A, Raimondi, Alejandra, Thomenius, Michael J
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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A687V EZH2 is a gain-of-function mutation found in lymphoma patients
Majer, Christina R., Jin, Lei, Scott, Margaret Porter, Knutson, Sarah K., Kuntz, Kevin W., Keilhack, Heike, Smith, Jesse J., Moyer, Mikel P., Richon, Victoria M., Copeland, Robert A., Wigle, Tim J.
Published in FEBS letters (21.09.2012)
Published in FEBS letters (21.09.2012)
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Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
Knutson, Sarah K, Warholic, Natalie M, Johnston, L Danielle, Klaus, Christine R, Wigle, Tim J, Iwanowicz, Dorothy, Littlefield, Bruce A, Porter-Scott, Margaret, Smith, Jesse J, Moyer, Mikel P, Copeland, Robert A, Pollock, Roy M, Kuntz, Kevin W, Raimondi, Alejandra, Keilhack, Heike
Published in PloS one (10.12.2014)
Published in PloS one (10.12.2014)
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The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
Wigle, Tim J., Knutson, Sarah K., Jin, Lei, Kuntz, Kevin W., Pollock, Roy M., Richon, Victoria M., Copeland, Robert A., Scott, Margaret Porter
Published in FEBS letters (03.10.2011)
Published in FEBS letters (03.10.2011)
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Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat
Razidlo, David F, Whitney, Tiffany J, Casper, Michelle E, McGee-Lawrence, Meghan E, Stensgard, Bridget A, Li, Xiaodong, Secreto, Frank J, Knutson, Sarah K, Hiebert, Scott W, Westendorf, Jennifer J
Published in PloS one (09.07.2010)
Published in PloS one (09.07.2010)
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Proceedings of the inaugural Dark Genome Symposium: November 2022
Boeke, Jef D, Burns, Kathleen H, Chiappinelli, Katherine B, Classon, Marie, Coffin, John M, DeCarvalho, Daniel D, Dukes, Joseph D, Greenbaum, Benjamin, Kassiotis, George, Knutson, Sarah K, Levine, Arnold J, Nath, Avindra, Papa, Sophie, Rios, Daniel, Sedivy, John, Ting, David T
Published in Mobile DNA (21.11.2023)
Published in Mobile DNA (21.11.2023)
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Correction: Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma
Kawano, Satoshi, Grassian, Alexandra R, Tsuda, Masumi, Knutson, Sarah K, Warholic, Natalie M, Kuznetsov, Galina, Xu, Shanqin, Xiao, Yonghong, Pollock, Roy M, Smith, Jesse J, Kuntz, Kevin W, Ribich, Scott, Minoshima, Yukinori, Matsui, Junji, Copeland, Robert A, Tanaka, Shinya, Keilhack, Heike
Published in PloS one (13.01.2017)
Published in PloS one (13.01.2017)
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Liver cancer initiation requires translational activation by an oncofetal regulon involving LIN28 proteins
Hsieh, Meng-Hsiung, Wei, Yonglong, Li, Lin, Nguyen, Liem H, Lin, Yu-Hsuan, Yoon, Jung M, Sun, Xuxu, Wang, Xun, Luo, Xin, Knutson, Sarah K, Bracken, Christina, Daley, George Q, Powers, John T, Zhu, Hao
Published in The Journal of clinical investigation (01.08.2024)
Published in The Journal of clinical investigation (01.08.2024)
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Targeting the synthetic lethal relationship between FOCAD and TUT7 represents a potential therapeutic opportunity for TUT4/7 small molecule inhibitors in cancer
Triboulet, Robinson, Sadykov, Khikmet, Harvey, Darren M, Wilson, David M, Steinbaugh, Michael J, Mayo, Christopher B, Hawley, Dillon, Madanjian, Andrew, Fyfe, Corey, Bracken, Christina, Rivera-Rivera, Izarys, Ericsson, Anna, Snyder, Andrew R, Knutson, Sarah K, Stein, Ross L, Gibaja, Veronica, Ghosh, Shomir, Campbell, Robert M
Published in Molecular cancer therapeutics (05.09.2024)
Published in Molecular cancer therapeutics (05.09.2024)
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