Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man
Hipp, Joerg F., Knoflach, Frederic, Comley, Robert, Ballard, Theresa M., Honer, Michael, Trube, Gerhard, Gasser, Rodolfo, Prinssen, Eric, Wallace, Tanya L., Rothfuss, Andreas, Knust, Henner, Lennon-Chrimes, Sian, Derks, Michael, Bentley, Darren, Squassante, Lisa, Nave, Stephane, Nöldeke, Jana, Wandel, Christoph, Thomas, Andrew W., Hernandez, Maria-Clemencia
Published in Scientific reports (08.04.2021)
Published in Scientific reports (08.04.2021)
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Journal Article
Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks
Burkhard, Johannes A, Guérot, Carine, Knust, Henner, Carreira, Erick M
Published in Organic letters (06.01.2012)
Published in Organic letters (06.01.2012)
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Journal Article
Synthesis of Novel Angular Spirocyclic Azetidines
Guérot, Carine, Tchitchanov, Boris H, Knust, Henner, Carreira, Erick M
Published in Organic letters (18.02.2011)
Published in Organic letters (18.02.2011)
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Journal Article
Preclinical Evaluation of 18F-RO6958948, 11C-RO6931643, and 11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease
Honer, Michael, Gobbi, Luca, Knust, Henner, Kuwabara, Hiroto, Muri, Dieter, Koerner, Matthias, Valentine, Heather, Dannals, Robert F, Wong, Dean F, Borroni, Edilio
Published in The Journal of nuclear medicine (1978) (01.04.2018)
Published in The Journal of nuclear medicine (1978) (01.04.2018)
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Journal Article
The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction
Knust, Henner, Achermann, Guido, Ballard, Theresa, Buettelmann, Bernd, Gasser, Rodolfo, Fischer, Holger, Hernandez, Maria-Clemencia, Knoflach, Frédéric, Koblet, Andreas, Stadler, Heinz, Thomas, Andrew W., Trube, Gerhard, Waldmeier, Pius
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Journal Article
Adventures in drug-like chemistry space: from oxetanes to spiroazetidines and beyond
Rogers-Evans, Mark, Knust, Henner, Plancher, Jean-Marc, Carreira, Erick M, Wuitschik, George, Burkhard, Johannes, Li, Dong B, Guérot, Carine
Published in Chimia (01.01.2014)
Published in Chimia (01.01.2014)
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Journal Article
RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors
Ballard, Theresa M., Knoflach, Frédéric, Prinssen, Eric, Borroni, Edilio, Vivian, Jeffrey A., Basile, Jennifer, Gasser, Rodolfo, Moreau, Jean-Luc, Wettstein, Joseph G., Buettelmann, Bernd, Knust, Henner, Thomas, Andrew W., Trube, Gerhard, Hernandez, Maria-Clemencia
Published in Psychopharmacology (01.01.2009)
Published in Psychopharmacology (01.01.2009)
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Journal Article
P4‐185: First in‐human PET study of 3 novel tau radiopharmaceuticals: [11C]RO6924963, [11C]RO6931643, and [18F]RO6958948
Wong, Dean F., Borroni, Edilio, Kuwabara, Hiroto, George, Noble, Rosenberg, Paul, Lyketsos, Constantine, Resnick, Susan M., Thambisetty, Madhav, Brasic, James, Gapasin, Lorena, Willis, William, Knust, Henner, Guerard, Melanie, Belli, Sara, Muri, Dieter, Carey, Tracie, Bedding, Alun, Wandel, Christoph, Hansrod, Tasnim, Honer, Michael, Moghekar, Abhay, Boess, Frank, Albert, Marilyn S., Shaya, Elias, Oh, Esther, Ostrowitzki, Susanne, Dannals, Robert F., Comley, Robert A.
Published in Alzheimer's & dementia (01.07.2015)
Published in Alzheimer's & dementia (01.07.2015)
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Journal Article
Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5–C16 degradation fragment of reidispongiolide A
Paterson, Ian, Britton, Robert, Ashton, Kate, Knust, Henner, Stafford, Jonathan
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.2004)
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Journal Article
Total synthesis of (-)-reidispongiolide A, an actin-targeting macrolide isolated from the marine sponge Reidispongia coerulea
Paterson, Ian, Ashton, Kate, Britton, Robert, Cecere, Giuseppe, Chouraqui, Gaëlle, Florence, Gordon J, Knust, Henner, Stafford, Jonathan
Published in Chemistry, an Asian journal (01.02.2008)
Published in Chemistry, an Asian journal (01.02.2008)
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Journal Article
Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series
ACHERMANN, Guido, BALLARD, Theresa M, KOBLET, Andreas, KNUST, Henner, KURT, Anke, MARTIN, James R, MASCIADRI, Raffaello, PORTER, Richard H. P, STADLER, Heinz, THOMAS, Andrew W, TRUBE, Gerhard, WICHMANN, Jürgen, BLASCO, Francesca, BROUTIN, Pierre-Emmanuel, BÜTTELMANN, Bernd, FISCHER, Holger, GRAF, Martin, HERNANDEZ, Maria-Clemencia, HILTY, Peter, KNOFLACH, Frédéric
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Journal Article
Toward the Synthesis of Reidispongiolide A: Stereocontrolled Synthesis of the C17−C22 and C23−C35 Degradation Fragments
Paterson, Ian, Ashton, Kate, Britton, Robert, Knust, Henner
Published in Organic letters (29.05.2003)
Published in Organic letters (29.05.2003)
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Journal Article
Synthesis of Fluorinated Tricyclic Scaffolds by Intramolecular [2+2] Photocycloaddition Reactions
Fort, Diego A., Woltering, Thomas J., Nettekoven, Matthias, Knust, Henner, Bach, Thorsten
Published in Angewandte Chemie (01.10.2012)
Published in Angewandte Chemie (01.10.2012)
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Journal Article
Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer’s Disease with Positron Emission Tomography
Gobbi, Luca C, Knust, Henner, Körner, Matthias, Honer, Michael, Czech, Christian, Belli, Sara, Muri, Dieter, Edelmann, Martin R, Hartung, Thomas, Erbsmehl, Isabella, Grall-Ulsemer, Sandra, Koblet, Andreas, Rueher, Marianne, Steiner, Sandra, Ravert, Hayden T, Mathews, William B, Holt, Daniel P, Kuwabara, Hiroto, Valentine, Heather, Dannals, Robert F, Wong, Dean F, Borroni, Edilio
Published in Journal of medicinal chemistry (14.09.2017)
Published in Journal of medicinal chemistry (14.09.2017)
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Journal Article
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines As Imaging Agents for Tau Fibrils and β‑Amyloid Plaques in Alzheimer’s Disease Models
Boländer, Alexander, Kieser, Daniel, Voss, Constantin, Bauer, Silvia, Schön, Christian, Burgold, Steffen, Bittner, Tobias, Hölzer, Jana, Heyny-von Haußen, Roland, Mall, Gerhard, Goetschy, Valérie, Czech, Christian, Knust, Henner, Berger, Robert, Herms, Jochen, Hilger, Ingrid, Schmidt, Boris
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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