Peptide Inhibitors of West Nile NS3 Protease: SAR Study of Tetrapeptide Aldehyde Inhibitors
Knox, John E, Ma, Ngai Ling, Yin, Zheng, Patel, Sejal J, Wang, Wei-Ling, Chan, Wai-Ling, Ranga Rao, K. R, Wang, Gang, Ngew, Xinyi, Patel, Viral, Beer, David, Lim, Siew Pheng, Vasudevan, Subhash G, Keller, Thomas H
Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
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Journal Article
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
Schulze, Christopher J., Seamon, Kyle J., Zhao, Yulei, Yang, Yu C., Cregg, Jim, Kim, Dongsung, Tomlinson, Aidan, Choy, Tiffany J., Wang, Zhican, Sang, Ben, Pourfarjam, Yasin, Lucas, Jessica, Cuevas-Navarro, Antonio, Ayala-Santos, Carlos, Vides, Alberto, Li, Chuanchuan, Marquez, Abby, Zhong, Mengqi, Vemulapalli, Vidyasiri, Weller, Caroline, Gould, Andrea, Whalen, Daniel M., Salvador, Anthony, Milin, Anthony, Saldajeno-Concar, Mae, Dinglasan, Nuntana, Chen, Anqi, Evans, Jim, Knox, John E., Koltun, Elena S., Singh, Mallika, Nichols, Robert, Wildes, David, Gill, Adrian L., Smith, Jacqueline A. M., Lito, Piro
Published in Science (American Association for the Advancement of Science) (18.08.2023)
Published in Science (American Association for the Advancement of Science) (18.08.2023)
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Journal Article
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Holderfield, Matthew, Lee, Bianca J., Jiang, Jingjing, Tomlinson, Aidan, Seamon, Kyle J., Mira, Alessia, Patrucco, Enrico, Goodhart, Grace, Dilly, Julien, Gindin, Yevgeniy, Dinglasan, Nuntana, Wang, Yingyun, Lai, Lick Pui, Cai, Shurui, Jiang, Lingyan, Nasholm, Nicole, Shifrin, Nataliya, Blaj, Cristina, Shah, Harshit, Evans, James W., Montazer, Nilufar, Lai, Oliver, Shi, Jade, Ahler, Ethan, Quintana, Elsa, Chang, Stephanie, Salvador, Anthony, Marquez, Abby, Cregg, Jim, Liu, Yang, Milin, Anthony, Chen, Anqi, Ziv, Tamar Bar, Parsons, Dylan, Knox, John E., Klomp, Jennifer E., Roth, Jennifer, Rees, Matthew, Ronan, Melissa, Cuevas-Navarro, Antonio, Hu, Feng, Lito, Piro, Santamaria, David, Aguirre, Andrew J., Waters, Andrew M., Der, Channing J., Ambrogio, Chiara, Wang, Zhengping, Gill, Adrian L., Koltun, Elena S., Smith, Jacqueline A. M., Wildes, David, Singh, Mallika
Published in Nature (London) (23.05.2024)
Published in Nature (London) (23.05.2024)
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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors
Burnett, G. Leslie, Yang, Yu C., Aggen, James B., Pitzen, Jennifer, Gliedt, Micah K., Semko, Chris M., Marquez, Abby, Evans, James W., Wang, Gang, Won, Walter S., Tomlinson, Aidan C. A., Kiss, Gert, Tzitzilonis, Christos, Thottumkara, Arun P., Cregg, James, Mellem, Kevin T., Choi, Jong S., Lee, Julie C., Zhao, Yongyuan, Lee, Bianca J., Meyerowitz, Justin G., Knox, John E., Jiang, Jingjing, Wang, Zhican, Wildes, David, Wang, Zhengping, Singh, Mallika, Smith, Jacqueline A. M., Gill, Adrian L.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Journal Article
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Jiang, Jingjing, Jiang, Lingyan, Maldonato, Benjamin J, Wang, Yingyun, Holderfield, Matthew, Aronchik, Ida, Winters, Ian P, Salman, Zeena, Blaj, Cristina, Menard, Marie, Brodbeck, Jens, Chen, Zhe, Wei, Xing, Rosen, Michael J, Gindin, Yevgeniy, Lee, Bianca J, Evans, James W, Chang, Stephanie, Wang, Zhican, Seamon, Kyle J, Parsons, Dylan, Cregg, James, Marquez, Abby, Tomlinson, Aidan C A, Yano, Jason K, Knox, John E, Quintana, Elsa, Aguirre, Andrew J, Arbour, Kathryn C, Reed, Abby, Gustafson, W Clay, Gill, Adrian L, Koltun, Elena S, Wildes, David, Smith, Jacqueline A M, Wang, Zhengping, Singh, Mallika
Published in Cancer discovery (09.04.2024)
Published in Cancer discovery (09.04.2024)
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Journal Article
Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography
Kroeck, Kyle G., Sacco, Michael D., Smith, Emmanuel W., Zhang, Xiujun, Shoun, Daniel, Akhtar, Afroza, Darch, Sophie E., Cohen, Frederick, Andrews, Logan D., Knox, John E., Chen, Yu
Published in Scientific reports (29.10.2019)
Published in Scientific reports (29.10.2019)
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Synthesis and antitubercular activity of 7-(R)-and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824
XIAOJIN LI, MANJUNATHA, Ujjini H, GOODWIN, Michael B, KNOX, John E, LIPINSKI, Christopher A, KELLER, Thomas H, BARRY, Clifton E, DOWD, Cynthia S
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Journal Article
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis
Kurabachew, Mekonnen, Lu, Stephen H. J., Krastel, Philipp, Schmitt, Esther K., Suresh, Bangalore L., Goh, Anne, Knox, John E., Ma, Ngai Ling, Jiricek, Jan, Beer, David, Cynamon, Michael, Petersen, Frank, Dartois, Veronique, Keller, Thomas, Dick, Thomas, Sambandamurthy, Vasan K.
Published in Journal of antimicrobial chemotherapy (01.10.2008)
Published in Journal of antimicrobial chemotherapy (01.10.2008)
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Journal Article
Chemical failure modes of AlQ3-based OLEDs: AlQ3 hydrolysis
Knox, John E, Halls, Mathew D, Hratchian, Hrant P, Schlegel, H Bernhard
Published in Physical chemistry chemical physics : PCCP (01.01.2006)
Published in Physical chemistry chemical physics : PCCP (01.01.2006)
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Journal Article
RAS 억제제
BURNETT G. LESLIE, KOLTUN ELENA S, GILL ADRIAN L, CREGG JAMES, LIU YANG, KNOX JOHN E
Year of Publication 03.09.2024
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Year of Publication 03.09.2024
Patent
RAS 억제제
BURNETT G. LESLIE, KOLTUN ELENA S, GILL ADRIAN L, CREGG JAMES, LIU YANG, KNOX JOHN E
Year of Publication 11.01.2024
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Year of Publication 11.01.2024
Patent
Experimental and Theoretical Study of the Coordination of 1,2,4-Triazolato, Tetrazolato, and Pentazolato Ligands to the [K(18-crown-6)]+ Fragment
Kobrsi, Issam, Zheng, Wenjun, Knox, John E, Heeg, Mary Jane, Schlegel, H. Bernhard, Winter, Charles H
Published in Inorganic chemistry (16.10.2006)
Published in Inorganic chemistry (16.10.2006)
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Journal Article
RAS 억제제
BUCKL ANDREAS, EDWARDS ANNE V, BURNETT G. LESLIE, KOLTUN ELENA S, SEMKO CHRISTOPHER, GILL ADRIAN L, CREGG JAMES, LIU YANG, KNOX JOHN E
Year of Publication 28.05.2024
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Year of Publication 28.05.2024
Patent
암의 치료를 위한 RAS 억제제
BUCKL ANDREAS, EDWARDS ANNE V, BURNETT G. LESLIE, KOLTUN ELENA S, SEMKO CHRISTOPHER, GILL ADRIAN L, CREGG JAMES, PITZEN JENNIFER, KNOX JOHN E
Year of Publication 08.02.2024
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Year of Publication 08.02.2024
Patent
Yellow fever virus NS3 protease: peptide-inhibition studies
Lohr, Kristina, Knox, John E, Phong, Wai Yee, Ma, Ngai Ling, Yin, Zheng, Sampath, Aruna, Patel, Sejal J, Wang, Wei-Ling, Chan, Wai-Ling, Rao, K. R. Ranga, Wang, Gang, Vasudevan, Subhash G, Keller, Thomas H, Lim, Siew Pheng
Published in Journal of general virology (01.08.2007)
Published in Journal of general virology (01.08.2007)
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Journal Article
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors
Yin, Zheng, Patel, Sejal J., Wang, Wei-Ling, Chan, Wai-Ling, Ranga Rao, K.R., Wang, Gang, Ngew, Xinyi, Patel, Viral, Beer, David, Knox, John E., Ma, Ngai Ling, Ehrhardt, Claus, Lim, Siew Pheng, Vasudevan, Subhash G., Keller, Thomas H.
Published in Bioorganic & medicinal chemistry letters (2006)
Published in Bioorganic & medicinal chemistry letters (2006)
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Journal Article
Synthesis, Structure, and Properties of Magnesocene Amine Adducts. Structural Distortions Arising from N−H···C5H5 - Hydrogen Bonding and Molecular Orbital Calculations Thereof
Xia, Aibing, Knox, John E, Heeg, Mary Jane, Schlegel, H. Bernhard, Winter, Charles H
Published in Organometallics (29.09.2003)
Published in Organometallics (29.09.2003)
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Journal Article
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BUCKL ANDREAS, BURNETT G. LESLIE, KOLTUN ELENA S, GILL ADRIAN L, CREGG JAMES, PITZEN JENNIFER, LIU YANG, KNOX JOHN E, AGGEN JAMES
Year of Publication 04.08.2022
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Year of Publication 04.08.2022
Patent
RAS 억제제
BUCKL ANDREAS, BURNETT G. LESLIE, WHALEN DANIEL M, KOLTUN ELENA S, GILL ADRIAN L, CREGG JAMES, AAY NAING, PITZEN JENNIFER, LIU YANG, KNOX JOHN E, AGGEN JAMES
Year of Publication 04.08.2022
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Year of Publication 04.08.2022
Patent
메티오닌 아데노실트랜스퍼라제 2A 억제제로서 2-옥소퀴나졸린 유도체
ALAM MUZAFFAR, NEWBY ZACHARY E. R, FLEURY MELISSA, PEI ZHONGHUA, STEEL RICHARD, SUTTON JAMES, KNOX JOHN E, CLEARY LEAH
Year of Publication 23.08.2021
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Year of Publication 23.08.2021
Patent