Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy
Loreth, Desirée, Ozmen, Laurence, Revel, Florent G, Knoflach, Frédéric, Wetzel, Philine, Frotscher, Michael, Metzger, Friedrich, Kretz, Oliver
Published in Neurobiology of disease (01.07.2012)
Published in Neurobiology of disease (01.07.2012)
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Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome
Martínez-Cué, Carmen, Martínez, Paula, Rueda, Noemí, Vidal, Rebeca, García, Susana, Vidal, Verónica, Corrales, Andrea, Montero, Juan A, Pazos, Ángel, Flórez, Jesús, Gasser, Rodolfo, Thomas, Andrew W, Honer, Michael, Knoflach, Frédéric, Trejo, Jose Luis, Wettstein, Joseph G, Hernández, Maria-Clemencia
Published in The Journal of neuroscience (27.02.2013)
Published in The Journal of neuroscience (27.02.2013)
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Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers
Vieira, Eric, Huwyler, Jörg, Jolidon, Synèse, Knoflach, Frédéric, Mutel, Vincent, Wichmann, Jürgen
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction
Knust, Henner, Achermann, Guido, Ballard, Theresa, Buettelmann, Bernd, Gasser, Rodolfo, Fischer, Holger, Hernandez, Maria-Clemencia, Knoflach, Frédéric, Koblet, Andreas, Stadler, Heinz, Thomas, Andrew W., Trube, Gerhard, Waldmeier, Pius
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Positive Allosteric Modulators of Metabotropic Glutamate 1 Receptor: Characterization, Mechanism of Action, and Binding Site
Knoflach, Frédéric, Mutel, Vincent, Jolidon, Synèse, James N. C. Kew, Malherbe, Pari, Vieira, Eric, Wichmann, Jürgen, Kemp, John A.
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2001)
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Journal Article
RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors
Ballard, Theresa M., Knoflach, Frédéric, Prinssen, Eric, Borroni, Edilio, Vivian, Jeffrey A., Basile, Jennifer, Gasser, Rodolfo, Moreau, Jean-Luc, Wettstein, Joseph G., Buettelmann, Bernd, Knust, Henner, Thomas, Andrew W., Trube, Gerhard, Hernandez, Maria-Clemencia
Published in Psychopharmacology (01.01.2009)
Published in Psychopharmacology (01.01.2009)
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Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor
Malherbe, Pari, Kratochwil, Nicole, Knoflach, Frédéric, Zenner, Marie-Thérèse, Kew, James N C, Kratzeisen, Claudia, Maerki, Hans P, Adam, Geo, Mutel, Vincent
Published in The Journal of biological chemistry (07.03.2003)
Published in The Journal of biological chemistry (07.03.2003)
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Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study
Umbricht, Daniel, Alberati, Daniela, Martin-Facklam, Meret, Borroni, Edilio, Youssef, Eriene A, Ostland, Michael, Wallace, Tanya L, Knoflach, Frédéric, Dorflinger, Ernest, Wettstein, Joseph G, Bausch, Alexander, Garibaldi, George, Santarelli, Luca
Published in JAMA psychiatry (Chicago, Ill.) (01.06.2014)
Published in JAMA psychiatry (Chicago, Ill.) (01.06.2014)
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Journal Article
Identification of a Corticohabenular Circuit Regulating Socially Directed Behavior
Benekareddy, Madhurima, Stachniak, Tevye Jason, Bruns, Andreas, Knoflach, Frederic, von Kienlin, Markus, Künnecke, Basil, Ghosh, Anirvan
Published in Biological psychiatry (1969) (01.04.2018)
Published in Biological psychiatry (1969) (01.04.2018)
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Discovery of the imidazo[1,5-α][1,2,4].triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series
ACHERMANN, Guido, BALLARD, Theresa M, KOBLET, Andreas, KNUST, Henner, KURT, Anke, MARTIN, James R, MASCIADRI, Raffaello, PORTER, Richard H. P, STADLER, Heinz, THOMAS, Andrew W, TRUBE, Gerhard, WICHMANN, Jürgen, BLASCO, Francesca, BROUTIN, Pierre-Emmanuel, BÜTTELMANN, Bernd, FISCHER, Holger, GRAF, Martin, HERNANDEZ, Maria-Clemencia, HILTY, Peter, KNOFLACH, Frédéric
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β
Bohrmann, Bernd, Baumann, Karlheinz, Benz, Jörg, Gerber, Francoise, Huber, Walter, Knoflach, Frédéric, Messer, Jürg, Oroszlan, Krisztina, Rauchenberger, Robert, Richter, Wolfgang F, Rothe, Christine, Urban, Margit, Bardroff, Michael, Winter, Michael, Nordstedt, Christer, Loetscher, Hansruedi
Published in Journal of Alzheimer's disease (01.01.2012)
Published in Journal of Alzheimer's disease (01.01.2012)
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mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis
Costa, Veronica, Aigner, Stefan, Vukcevic, Mirko, Sauter, Evelyn, Behr, Katharina, Ebeling, Martin, Dunkley, Tom, Friedlein, Arno, Zoffmann, Sannah, Meyer, Claas A., Knoflach, Frédéric, Lugert, Sebastian, Patsch, Christoph, Fjeldskaar, Fatiha, Chicha-Gaudimier, Laurie, Kiialainen, Anna, Piraino, Paolo, Bedoucha, Marc, Graf, Martin, Jessberger, Sebastian, Ghosh, Anirvan, Bischofberger, Josef, Jagasia, Ravi
Published in Cell reports (Cambridge) (05.04.2016)
Published in Cell reports (Cambridge) (05.04.2016)
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Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man
Hipp, Joerg F., Knoflach, Frederic, Comley, Robert, Ballard, Theresa M., Honer, Michael, Trube, Gerhard, Gasser, Rodolfo, Prinssen, Eric, Wallace, Tanya L., Rothfuss, Andreas, Knust, Henner, Lennon-Chrimes, Sian, Derks, Michael, Bentley, Darren, Squassante, Lisa, Nave, Stephane, Nöldeke, Jana, Wandel, Christoph, Thomas, Andrew W., Hernandez, Maria-Clemencia
Published in Scientific reports (08.04.2021)
Published in Scientific reports (08.04.2021)
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Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target
Goeldner, Celia, Ballard, Theresa M., Knoflach, Frederic, Wichmann, Juergen, Gatti, Silvia, Umbricht, Daniel
Published in Neuropharmacology (01.01.2013)
Published in Neuropharmacology (01.01.2013)
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