Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems
Raue, A, Steiert, B, Schelker, M, Kreutz, C, Maiwald, T, Hass, H, Vanlier, J, Tönsing, C, Adlung, L, Engesser, R, Mader, W, Heinemann, T, Hasenauer, J, Schilling, M, Höfer, T, Klipp, E, Theis, F, Klingmüller, U, Schöberl, B, Timmer, J
Published in Bioinformatics (01.11.2015)
Published in Bioinformatics (01.11.2015)
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Journal Article
Predictive mathematical models of cancer signalling pathways
Bachmann, J., Raue, A., Schilling, M., Becker, V., Timmer, J., Klingmüller, U.
Published in Journal of internal medicine (01.02.2012)
Published in Journal of internal medicine (01.02.2012)
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Journal Article
Conference Proceeding
High-dimensional Bayesian parameter estimation: Case study for a model of JAK2/STAT5 signaling
Hug, S., Raue, A., Hasenauer, J., Bachmann, J., Klingmüller, U., Timmer, J., Theis, F.J.
Published in Mathematical biosciences (01.12.2013)
Published in Mathematical biosciences (01.12.2013)
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Journal Article
Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response
Dvornikov, D., Schneider, M. A., Ohse, S., Szczygieł, M., Titkova, I., Rosenblatt, M., Muley, T., Warth, A., Herth, F. J., Dienemann, H., Thomas, M., Timmer, J., Schilling, M., Busch, H., Boerries, M., Meister, M., Klingmüller, U.
Published in Scientific reports (22.06.2018)
Published in Scientific reports (22.06.2018)
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Journal Article
Unraveling liver complexity from molecular to organ level: Challenges and perspectives
D'Alessandro, L.A., Hoehme, S., Henney, A., Drasdo, D., Klingmüller, U.
Published in Progress in biophysics and molecular biology (01.01.2015)
Published in Progress in biophysics and molecular biology (01.01.2015)
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Journal Article
Characterisation of cell-type-specific responses in the liver towards IL-1β by a mathematical model for the p38MAPK/MK2 pathway
Kulawik, A, Engesser, R, Ehlting, C, Raue, A, Albrecht, U, Wolf, S, Gaestel, M, Klingmüller, U, Häussinger, D, Timmer, J, Bode, J.G
Published in Journal of hepatology (2017)
Published in Journal of hepatology (2017)
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Journal Article
Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways
Klingmüller, U, Bauer, A, Bohl, S, Nickel, P J, Breitkopf, K, Dooley, S, Zellmer, S, Kern, C, Merfort, I, Sparna, T, Donauer, J, Walz, G, Geyer, M, Kreutz, C, Hermes, M, Götschel, F, Hecht, A, Walter, D, Egger, L, Neubert, K, Borner, C, Brulport, M, Schormann, W, Sauer, C, Baumann, F, Preiss, R, MacNelly, S, Godoy, P, Wiercinska, E, Ciuclan, L, Edelmann, J, Zeilinger, K, Heinrich, M, Zanger, U M, Gebhardt, R, Maiwald, T, Heinrich, R, Timmer, J, von Weizsäcker, F, Hengstler, J G
Published in Systems biology (01.11.2006)
Published in Systems biology (01.11.2006)
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Journal Article
Spatial aspects in the SMAD signaling pathway
Claus, J., Friedmann, E., Klingmüller, U., Rannacher, R., Szekeres, T.
Published in Journal of mathematical biology (01.11.2013)
Published in Journal of mathematical biology (01.11.2013)
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Journal Article
P0428 : LPS-stimulated mouse hepatic stellate cells secrete specific factors that directly contribute to the acute phase response of hepatocytes
Breitkopf-Heinlein, K, Liebe, R, Waldow, K, Braun, S, Thomas, M, Schildberg, F, Knolle, P, Zanger, U, Klingmüller, U, Ebert, M, Dooley, S
Published in Journal of hepatology (01.04.2015)
Published in Journal of hepatology (01.04.2015)
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Journal Article
P117 HOLISTIC APPROACH TO UNRAVEL FUNCTIONS AND REGULATION OF HGF IN LIVER REGENERATION
D'Alessandro, L.A, Meyer, C, Hengstler, J.G, Klingmüller, U, Höhme, S, el Kariem, S, Safferling, K, Raue, A, Timmer, J, Drasdo, D, Grabe, N, Dooley, S
Published in Journal of hepatology (01.04.2014)
Published in Journal of hepatology (01.04.2014)
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Journal Article
Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor
Kubatzky, Katharina F., Ruan, Weiming, Gurezka, Rolf, Cohen, Jacob, Ketteler, Robin, Watowich, Stephanie S., Neumann, Drorit, Langosch, Dieter, Klingmüller, Ursula
Published in Current biology (23.01.2001)
Published in Current biology (23.01.2001)
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Journal Article
Addressing parameter identifiability by model-based experimentation
Raue, A, Kreutz, C, Maiwald, T, Klingmuller, U, Timmer, J
Published in IET systems biology (01.03.2011)
Published in IET systems biology (01.03.2011)
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Journal Article
Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1
KORTYLEWSKI, M, HEINRICH, P. C, MACKIEWICZ, A, SCHNIERTSHAUER, U, KLINGMÜLLER, U, NAKAJIMA, K, HIRANO, T, HORN, F, BEHRMANN, I
Published in Oncogene (24.06.1999)
Published in Oncogene (24.06.1999)
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Journal Article
Identification of a Novel Pathway Important for Proliferation and Differentiation of Primary Erythroid Progenitors
Klingmuller, Ursula, Wu, Hong, Hsiao, Jonathan G., Toker, Alex, Duckworth, Brian C., Cantley, Lewis C., Lodish, Harvey F.
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.1997)
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Journal Article
P69.01 The Role of the Pregnancy Associated Protein Glycodelin and Its Influence on the Immune System in Non-Small-Cell Lung Cancer
Richtmann, S., Muley, T., Christopoulos, P., Thomas, M., Winter, H., Klingmüller, U., Meister, M., Schneider, M.
Published in Journal of thoracic oncology (01.10.2021)
Published in Journal of thoracic oncology (01.10.2021)
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Journal Article
Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders
Bochtler, T, Kirsch, M, Maier, B, Bachmann, J, Klingmüller, U, Anderhub, S, Ho, A D, Krämer, A
Published in Leukemia (01.04.2012)
Published in Leukemia (01.04.2012)
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