TORC1 inhibition enhances immune function and reduces infections in the elderly
Mannick, Joan B, Morris, Melody, Hockey, Hans-Ulrich P, Roma, Guglielmo, Beibel, Martin, Kulmatycki, Kenneth, Watkins, Mollie, Shavlakadze, Tea, Zhou, Weihua, Quinn, Dean, Glass, David J, Klickstein, Lloyd B
Published in Science translational medicine (11.07.2018)
Published in Science translational medicine (11.07.2018)
Get more information
Journal Article
Rituximab for steroid-refractory chronic graft-versus-host disease
Cutler, Corey, Miklos, David, Kim, Haesook T., Treister, Nathaniel, Woo, Sook-Bin, Bienfang, Don, Klickstein, Lloyd B., Levin, Jesse, Miller, Katherine, Reynolds, Carol, Macdonell, Rebecca, Pasek, Mildred, Lee, Stephanie J., Ho, Vincent, Soiffer, Robert, Antin, Joseph H., Ritz, Jerome, Alyea, Edwin
Published in Blood (15.07.2006)
Published in Blood (15.07.2006)
Get full text
Journal Article
Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents
Hernandez, Eloy D., Zheng, Lianxing, Kim, Young, Fang, Bin, Liu, Bo, Valdez, Reginald A., Dietrich, William F., Rucker, Paul V., Chianelli, Donatella, Schmeits, James, Bao, Dingjiu, Zoll, Jocelyn, Dubois, Claire, Federe, Glenn C., Chen, Lihao, Joseph, Sean B., Klickstein, Lloyd B., Walker, John, Molteni, Valentina, McNamara, Peter, Meeusen, Shelly, Tully, David C., Badman, Michael K., Xu, Jie, Laffitte, Bryan
Published in Hepatology communications (01.08.2019)
Published in Hepatology communications (01.08.2019)
Get full text
Journal Article
Farnesoid X receptor agonist tropifexor attenuates cholestasis in a randomised trial in patients with primary biliary cholangitis
Schramm, Christoph, Wedemeyer, Heiner, Mason, Andrew, Hirschfield, Gideon M., Levy, Cynthia, Kowdley, Kris V., Milkiewicz, Piotr, Janczewska, Ewa, Malova, Elena Sergeevna, Sanni, Johanne, Koo, Phillip, Chen, Jin, Choudhury, Subhajit, Klickstein, Lloyd B., Badman, Michael K., Jones, David
Published in JHEP reports (01.11.2022)
Published in JHEP reports (01.11.2022)
Get full text
Journal Article
Serological Investigation of the Collagen Degradation Profile of Patients with Chronic Obstructive Pulmonary Disease or Idiopathic Pulmonary Fibrosis
Leeming, Diana J., Sand, Jannie M., Nielsen, Mette J., Genovese, Federica, Martinez, Fernando J., Hogaboam, Cory M., Han, MeiLan K, Klickstein, Lloyd B., Karsdal, Morten A.
Published in Biomarker Insights (01.01.2012)
Published in Biomarker Insights (01.01.2012)
Get full text
Journal Article
Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation
Skjøt-Arkil, Helene, Clausen, Rikke E, Nguyen, Quoc Hai Trieu, Wang, Yaguo, Zheng, Qinlong, Martinez, Fernando J, Hogaboam, Cory M, Han, Meilan, Klickstein, Lloyd B, Larsen, Martin R, Nawrocki, Arkadiusz, Leeming, Diana J, Karsdal, Morten A
Published in BMC pulmonary medicine (20.07.2012)
Published in BMC pulmonary medicine (20.07.2012)
Get full text
Journal Article
mTOR inhibition improves immune function in the elderly
Mannick, Joan B, Del Giudice, Giuseppe, Lattanzi, Maria, Valiante, Nicholas M, Praestgaard, Jens, Huang, Baisong, Lonetto, Michael A, Maecker, Holden T, Kovarik, John, Carson, Simon, Glass, David J, Klickstein, Lloyd B
Published in Science translational medicine (24.12.2014)
Published in Science translational medicine (24.12.2014)
Get more information
Journal Article
Manifestations of Inflammatory Arthritis Are Critically Dependent on LFA-1
Watts, Gerald M, Beurskens, Frank J. M, Martin-Padura, Ines, Ballantyne, Christie M, Klickstein, Lloyd B, Brenner, Michael B, Lee, David M
Published in The Journal of immunology (1950) (15.03.2005)
Published in The Journal of immunology (1950) (15.03.2005)
Get full text
Journal Article
RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes
Klickstein, Lloyd B, Cherry, Lisa K, Li, Xiaoyu, Schwab, Pascale, Lim, Bing
Published in Nature immunology (01.09.2004)
Published in Nature immunology (01.09.2004)
Get full text
Journal Article
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers
Badman, Michael K., Chen, Jin, Desai, Sachin, Vaidya, Soniya, Neelakantham, Srikanth, Zhang, Jie, Gan, Lu, Danis, Kate, Laffitte, Bryan, Klickstein, Lloyd B.
Published in Clinical pharmacology in drug development (01.04.2020)
Published in Clinical pharmacology in drug development (01.04.2020)
Get full text
Journal Article
The Integrin α-Subunit Leg Extends at a Ca2+-Dependent Epitope in the Thigh/Genu Interface upon Activation
Xie, Can, Shimaoka, Motomu, Xiao, Tsan, Schwab, Pascale, Klickstein, Lloyd B., Springer, Timothy A.
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.2004)
Get full text
Journal Article
Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology
Shavlakadze, Tea, Zhu, Jiang, Wang, Sharon, Zhou, Weihua, Morin, Bret, Egerman, Marc A, Fan, Lin, Wang, Yanqun, Iartchouk, Oleg, Meyer, Angelika, Valdez, Reginald A, Mannick, Joan B, Klickstein, Lloyd B, Glass, David J
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (14.06.2018)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (14.06.2018)
Get more information
Journal Article
Synergistic Strategies to Accelerate the Development of Function-Promoting Therapies: Lessons From Operation Warp Speed and Oncology Drug Development
Correa-de Araujo, Rosaly, Evans, William J, Fielding, Roger A, Krishnan, Venkatesh, Carter, Robert H, Appleby, James, Guralnik, Jack, Klickstein, Lloyd B, Marks, Peter, Moore, Alison A, Peschin, Sue, Bhasin, Shalender
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (16.06.2023)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (16.06.2023)
Get more information
Journal Article
A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants
Stringer, Rowan, Chen, Jin, Shah, Bharti, Gu, Jessie, Zhang, Yiming, Prince, William, Klickstein, Lloyd B., Woessner, Ralph
Published in Clinical pharmacology in drug development (01.02.2023)
Published in Clinical pharmacology in drug development (01.02.2023)
Get full text
Journal Article
C1q and C4b Bind Simultaneously to CR1 and Additively Support Erythrocyte Adhesion
Tas, Sander W, Klickstein, Lloyd B, Barbashov, Sergei F, Nicholson-Weller, Anne
Published in The Journal of immunology (1950) (01.11.1999)
Published in The Journal of immunology (1950) (01.11.1999)
Get full text
Journal Article
AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women
John, Markus R, Harfst, Evita, Loeffler, Juergen, Belleli, Rossella, Mason, June, Bruin, Gerard J.M, Seuwen, Klaus, Klickstein, Lloyd B, Mindeholm, Linda, Widler, Leo, Kneissel, Michaela
Published in Bone (New York, N.Y.) (01.07.2014)
Published in Bone (New York, N.Y.) (01.07.2014)
Get full text
Journal Article
Aggregatibacter actinomycetemcomitans leukotoxin requires ?-sheets 1 and 2 of the human CD11a ?-propeller for cytotoxicity
Kieba, Irene R., Fong, Karen P., Tang, Hsin-Yao, Hoffman, Karl E., Speicher, David W., Klickstein, Lloyd B., Lally, Edward T.
Published in Cellular microbiology (01.11.2007)
Published in Cellular microbiology (01.11.2007)
Get full text
Journal Article