Design, Synthesis, and Evaluation of Indolinones as Inhibitors of the Transforming Growth Factor β Receptor I (TGFβRI)
Roth, Gerald J, Heckel, Armin, Brandl, Trixi, Grauert, Matthias, Hoerer, Stefan, Kley, Joerg T, Schnapp, Gisela, Baum, Patrick, Mennerich, Detlev, Schnapp, Andreas, Park, John E
Published in Journal of medicinal chemistry (28.10.2010)
Published in Journal of medicinal chemistry (28.10.2010)
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Characterization and comparative evaluation of a novel PAI-1 inhibitor
Gils, Ann, Stassen, Jean-Marie, Nar, Herbert, Kley, Joerg T, Wienen, Wolfgang, Ries, Uwe J, Declerck, Paul J
Published in Thrombosis and haemostasis (01.07.2002)
Published in Thrombosis and haemostasis (01.07.2002)
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Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability
Heine, Niklas, Weber, Alexander, Pautsch, Alexander, Gottschling, Dirk, Uphues, Ingo, Bauer, Margit, Ebenhoch, Rebecca, Magarkar, Aniket, Nosse, Bernd, Kley, Jörg Thomas
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
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Crystal structures of human and mouse ketohexokinase provide a structural basis for species‐ and isoform‐selective inhibitor design
Ebenhoch, Rebecca, Bauer, Margit, Romig, Helmut, Gottschling, Dirk, Kley, Jörg Thomas, Heine, Niklas, Weber, Alexander, Uphues, Ingo, Nar, Herbert, Pautsch, Alexander
Published in Acta crystallographica. Section D, Biological crystallography. (01.10.2023)
Published in Acta crystallographica. Section D, Biological crystallography. (01.10.2023)
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Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis
Betzemeier, Bodo, Braun, Clemens, Sieger, Peter, Heckel, Armin, Linz, Günter, Linehan, Brian, Veser, Thomas, Wiedenmayer, Dieter, Kley, Jörg T.
Published in European journal of medicinal chemistry (05.02.2024)
Published in European journal of medicinal chemistry (05.02.2024)
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The azulene scaffold from a medicinal chemist's perspective: Physicochemical and in vitro parameters relevant for drug discovery
Leino, Teppo O., Sieger, Peter, Yli-Kauhaluoma, Jari, Wallén, Erik A.A., Kley, Jörg T.
Published in European journal of medicinal chemistry (05.07.2022)
Published in European journal of medicinal chemistry (05.07.2022)
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Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)
Roth, Gerald J, Heckel, Armin, Colbatzky, Florian, Handschuh, Sandra, Kley, Jörg, Lehmann-Lintz, Thorsten, Lotz, Ralf, Tontsch-Grunt, Ulrike, Walter, Rainer, Hilberg, Frank
Published in Journal of medicinal chemistry (23.07.2009)
Published in Journal of medicinal chemistry (23.07.2009)
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cGAS 억제제로서의 N-연결된 사이클릭 치환체를 갖는 피리딘 유도체
GNAMM CHRISTIAN, KLEY JOERG, GODBOUT CEDRICKX, GROSS PATRICK, GRUNDL MARC ALEXANDER, STUBER RAPHAEL, THEIS THEODOR, HOENKE CHRISTOPH, KUTTRUFF CHRISTIAN ANDREAS, HANDSCHUH SANDRA RUTH, REINERT DIRK, HEIMANN ANNEKATRIN CHARLOTTE
Year of Publication 16.01.2024
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Year of Publication 16.01.2024
Patent
cGAS 억제제로서의 C-연결된 사이클릭 치환체를 갖는 피리딘 유도체
GNAMM CHRISTIAN, KLEY JOERG, GODBOUT CEDRICKX, GROSS PATRICK, GRUNDL MARC ALEXANDER, STUBER RAPHAEL, THEIS THEODOR, HOENKE CHRISTOPH, KUTTRUFF CHRISTIAN ANDREAS, HANDSCHUH SANDRA RUTH, REINERT DIRK, HEIMANN ANNEKATRIN CHARLOTTE
Year of Publication 15.01.2024
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Year of Publication 15.01.2024
Patent
Chemical Derivatization Enables MALDI-TOF-Based High-Throughput Screening for Microbial Trimethylamine (TMA)-Lyase Inhibitors
Winter, Martin, Bretschneider, Tom, Thamm, Sven, Kleiner, Carola, Grabowski, Daniel, Chandler, Sarah, Ries, Robert, Kley, Jörg T., Fowler, Danielle, Bartlett, Christina, Binetti, Ralph, Broadwater, John, Luippold, Andreas H., Bischoff, Daniel, Büttner, Frank H.
Published in SLAS discovery (01.08.2019)
Published in SLAS discovery (01.08.2019)
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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part III: Discovery of pre-clinical development candidate BI 186908
Oost, Thorsten, Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Müller, Stephan, Roth, Gerald J., Rudolf, Klaus, Arndt, Kirsten, Budzinski, Ralph, Lenter, Martin, Lotz, Ralf R.H., Maier, Gerd-Michael, Markert, Michael, Thomas, Leo, Stenkamp, Dirk
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition
Roth, Gerald J., Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Müller, Stephan G., Oost, Thorsten, Rudolf, Klaus, Arndt, Kirsten, Budzinski, Ralph, Lenter, Martin, Lotz, Ralf R.H., Schindler, Marcus, Thomas, Leo, Stenkamp, Dirk
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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