Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling
McCommis, Kyle S., Chen, Zhouji, Fu, Xiaorong, McDonald, William G., Colca, Jerry R., Kletzien, Rolf F., Burgess, Shawn C., Finck, Brian N.
Published in Cell metabolism (06.10.2015)
Published in Cell metabolism (06.10.2015)
Get full text
Journal Article
Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion
Vigueira, Patrick A., McCommis, Kyle S., Schweitzer, George G., Remedi, Maria S., Chambers, Kari T., Fu, Xiaorong, McDonald, William G., Cole, Serena L., Colca, Jerry R., Kletzien, Rolf F., Burgess, Shawn C., Finck, Brian N.
Published in Cell reports (Cambridge) (26.06.2014)
Published in Cell reports (Cambridge) (26.06.2014)
Get full text
Journal Article
Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins
Colca, Jerry R, McDonald, William G, Cavey, Gregory S, Cole, Serena L, Holewa, Danielle D, Brightwell-Conrad, Angela S, Wolfe, Cindy L, Wheeler, Jean S, Coulter, Kristin R, Kilkuskie, Peter M, Gracheva, Elena, Korshunova, Yulia, Trusgnich, Michelle, Karr, Robert, Wiley, Sandra E, Divakaruni, Ajit S, Murphy, Anne N, Vigueira, Patrick A, Finck, Brian N, Kletzien, Rolf F
Published in PloS one (15.05.2013)
Published in PloS one (15.05.2013)
Get full text
Journal Article
Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione
Chen, Zhouji, Vigueira, Patrick A., Chambers, Kari T., Hall, Angela M., Mitra, Mayurranjan S., Qi, Nathan, McDonald, William G., Colca, Jerry R., Kletzien, Rolf F., Finck, Brian N.
Published in The Journal of biological chemistry (06.07.2012)
Published in The Journal of biological chemistry (06.07.2012)
Get full text
Journal Article
PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development
Tanis, Steven P., Colca, Jerry R., Parker, Timothy T., Artman, Gerald D., Larsen, Scott D., McDonald, William G., Gadwood, Robert C., Kletzien, Rolf F., Zeller, James B., Lee, Pil H., Adams, Wade J.
Published in Bioorganic & medicinal chemistry (01.12.2018)
Published in Bioorganic & medicinal chemistry (01.12.2018)
Get full text
Journal Article
The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism
Vigueira, Patrick A., McCommis, Kyle S., Hodges, Wesley T., Schweitzer, George G., Cole, Serena L., Oonthonpan, Lalita, Taylor, Eric B., McDonald, William G., Kletzien, Rolf F., Colca, Jerry R., Finck, Brian N.
Published in Experimental physiology (01.08.2017)
Published in Experimental physiology (01.08.2017)
Get full text
Journal Article
Selenium: potent stimulator of tyrosyl phosphorylation and activator of MAP kinase
Stapleton, Susan R, Garlock, Ginny L, Foellmi-Adams, Lisa, Kletzien, Rolf F
Published in Biochimica et biophysica acta (01.03.1997)
Published in Biochimica et biophysica acta (01.03.1997)
Get full text
Journal Article
Insulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARγ
Bolten, Charles W., Blanner, Patrick M., McDonald, William G., Staten, Nicholas R., Mazzarella, Richard A., Arhancet, Graciela B., Meier, Martin F., Weiss, David J., Sullivan, Patrick M., Hromockyj, Alexander E., Kletzien, Rolf F., Colca, Jerry R.
Published in Gene regulation and systems biology (01.01.2007)
Published in Gene regulation and systems biology (01.01.2007)
Get full text
Journal Article
An efficient method to express and refold a truncated human procaspase-9: A caspase with activity toward Glu-X bonds
Sadhukhan, Ramkrishna, Leone, Joseph W., Lull, June, Wang, Zhigang, Kletzien, Rolf F., Heinrikson, Robert L., Tomasselli, Alfredo G.
Published in Protein expression and purification (01.04.2006)
Published in Protein expression and purification (01.04.2006)
Get full text
Journal Article
Current and Emerging Strategies for Treating Dyslipidemia and Macrovascular Disease
Get full text
Book Chapter
Journal Article
A dual MTOR/NAD+ acting gerotherapy
Li, Jinmei, Kumar, Sandeep, Miachin, Kirill, Bean, Nicholas L, Halawi, Ornella, Lee, Scott, Niehoff, Michael, Pierre, Tanya H, Colca, Jerry, Kletzien, Rolf F, Tanis, Steven P, Chen, Yana, Griffett, Kristine, Miller, Tim M, Jin-Hui Hor, Shi-Yan, Ng, Wallace, Kelvin, Rindtorff, Niklas, Farr, Susan A, Mccommis, Kyle S, Finck, Brian N, Peterson, Tim R
Published in bioRxiv (19.01.2023)
Published in bioRxiv (19.01.2023)
Get full text
Paper
Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains [beta]-Cell Phenotype in Human Islets
Rohatgi, Nidhi, Aly, Haytham, Marshall, Connie A, McDonald, William G, Kletzien, Rolf F, Colca, Jerry R, McDaniel, Michael L
Published in PloS one (01.05.2013)
Published in PloS one (01.05.2013)
Get full text
Journal Article