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Published in Nature chemistry (01.09.2020)
Published in Nature chemistry (01.09.2020)
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Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase
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α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease
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Published in Nature communications (12.06.2018)
Published in Nature communications (12.06.2018)
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Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Angelova, Plamena R, Choi, Minee L, Berezhnov, Alexey V, Horrocks, Mathew H, Hughes, Craig D, De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S, Kunath, Tilo, Devine, Michael J, Gissen, Paul, Shchepinov, Mikhail S, Sylantyev, Sergiy, Pavlov, Evgeny V, Klenerman, David, Abramov, Andrey Y, Gandhi, Sonia
Published in Cell death and differentiation (01.10.2020)
Published in Cell death and differentiation (01.10.2020)
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Nanopore extended field-effect transistor for selective single-molecule biosensing
Ren, Ren, Zhang, Yanjun, Nadappuram, Binoy Paulose, Akpinar, Bernice, Klenerman, David, Ivanov, Aleksandar P, Edel, Joshua B, Korchev, Yuri
Published in Nature communications (19.09.2017)
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Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
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Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2015)
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Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Hughes, Craig D., Choi, Minee L., Ryten, Mina, Hopkins, Lee, Drews, Anna, Botía, Juan A., Iljina, Maria, Rodrigues, Margarida, Gagliano, Sarah A., Gandhi, Sonia, Bryant, Clare, Klenerman, David
Published in Acta neuropathologica (01.01.2019)
Published in Acta neuropathologica (01.01.2019)
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Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
De, Suman, Wirthensohn, David C, Flagmeier, Patrick, Hughes, Craig, Aprile, Francesco A, Ruggeri, Francesco S, Whiten, Daniel R, Emin, Derya, Xia, Zengjie, Varela, Juan A, Sormanni, Pietro, Kundel, Franziska, Knowles, Tuomas P J, Dobson, Christopher M, Bryant, Clare, Vendruscolo, Michele, Klenerman, David
Published in Nature communications (04.04.2019)
Published in Nature communications (04.04.2019)
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Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
Emin, Derya, Zhang, Yu P., Lobanova, Evgeniia, Miller, Alyssa, Li, Xuecong, Xia, Zengjie, Dakin, Helen, Sideris, Dimitrios I., Lam, Jeff Y. L., Ranasinghe, Rohan T., Kouli, Antonina, Zhao, Yanyan, De, Suman, Knowles, Tuomas P. J., Vendruscolo, Michele, Ruggeri, Francesco S., Aigbirhio, Franklin I., Williams-Gray, Caroline H., Klenerman, David
Published in Nature communications (20.09.2022)
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Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Iljina, Marija, Garcia, Gonzalo A., Horrocks, Mathew H., Tosatto, Laura, Choi, Minee L., Ganzinger, Kristina A., Abramov, Andrey Y., Gandhi, Sonia, Wood, Nicholas W., Cremades, Nunilo, Dobson, Christopher M., Knowles, Tuomas P. J., Klenerman, David
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
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A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
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Published in Nature communications (30.04.2015)
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Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping
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Published in Nature communications (08.12.2016)
Published in Nature communications (08.12.2016)
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MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling
Moncrieffe, Martin C., Bollschweiler, Daniel, Li, Bing, Penczek, Pawel A., Hopkins, Lee, Bryant, Clare E., Klenerman, David, Gay, Nicholas J.
Published in Structure (London) (03.03.2020)
Published in Structure (London) (03.03.2020)
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Topographical and electrochemical nanoscale imaging of living cells using voltage-switching mode scanning electrochemical microscopy
Takahashi, Yasufumi, Shevchuk, Andrew I., Novak, Pavel, Babakinejad, Babak, Macpherson, Julie, Unwin, Patrick R., Shiku, Hitoshi, Gorelik, Julia, Klenerman, David, Korchev, Yuri E., Matsue, Tomokazu
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2012)
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Ultrarapid Generation of Femtoliter Microfluidic Droplets for Single-Molecule-Counting Immunoassays
Shim, Jung-uk, Ranasinghe, Rohan T, Smith, Clive A, Ibrahim, Shehu M, Hollfelder, Florian, Huck, Wilhelm T. S, Klenerman, David, Abell, Chris
Published in ACS nano (23.07.2013)
Published in ACS nano (23.07.2013)
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Spectrally Resolved Photodynamics of Individual Emitters in Large-Area Monolayers of Hexagonal Boron Nitride
Stern, Hannah L, Wang, Ruizhi, Fan, Ye, Mizuta, Ryo, Stewart, James C, Needham, Lisa-Maria, Roberts, Trevor D, Wai, Rebecca, Ginsberg, Naomi S, Klenerman, David, Hofmann, Stephan, Lee, Steven F
Published in ACS nano (23.04.2019)
Published in ACS nano (23.04.2019)
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High-resolution label-free 3D mapping of extracellular pH of single living cells
Zhang, Yanjun, Takahashi, Yasufumi, Hong, Sung Pil, Liu, Fengjie, Bednarska, Joanna, Goff, Philip S, Novak, Pavel, Shevchuk, Andrew, Gopal, Sahana, Barozzi, Iros, Magnani, Luca, Sakai, Hideki, Suguru, Yoshimoto, Fujii, Takuto, Erofeev, Alexander, Gorelkin, Peter, Majouga, Alexander, Weiss, Dominik J, Edwards, Christopher, Ivanov, Aleksandar P, Klenerman, David, Sviderskaya, Elena V, Edel, Joshua B, Korchev, Yuri
Published in Nature communications (06.12.2019)
Published in Nature communications (06.12.2019)
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Ubiquitin chain conformation regulates recognition and activity of interacting proteins
YU YE, BLASER, Georg, HORROCKS, Mathew H, RUEDAS-RAMA, Maria J, IBRAHIM, Shehu, ZHUKOV, Alexander A, ORTE, Angel, KLENERMAN, David, JACKSON, Sophie E, KOMANDER, David
Published in Nature (London) (13.12.2012)
Published in Nature (London) (13.12.2012)
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