Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
Kleinschek, Melanie A, Boniface, Katia, Sadekova, Svetlana, Grein, Jeff, Murphy, Erin E, Turner, Scott P, Raskin, Lisa, Desai, Bela, Faubion, William A, de Waal Malefyt, Rene, Pierce, Robert H, McClanahan, Terrill, Kastelein, Robert A
Published in The Journal of experimental medicine (16.03.2009)
Published in The Journal of experimental medicine (16.03.2009)
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IL-25 regulates Th17 function in autoimmune inflammation
Kleinschek, Melanie A, Owyang, Alexander M, Joyce-Shaikh, Barbara, Langrish, Claire L, Chen, Yi, Gorman, Daniel M, Blumenschein, Wendy M, McClanahan, Terrill, Brombacher, Frank, Hurst, Stephen D, Kastelein, Robert A, Cua, Daniel J
Published in The Journal of experimental medicine (22.01.2007)
Published in The Journal of experimental medicine (22.01.2007)
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IL-23 Enhances the Inflammatory Cell Response in Cryptococcus neoformans Infection and Induces a Cytokine Pattern Distinct from IL-12
Kleinschek, Melanie A, Muller, Uwe, Brodie, Scott J, Stenzel, Werner, Kohler, Gabriele, Blumenschein, Wendy M, Straubinger, Reinhard K, McClanahan, Terrill, Kastelein, Robert A, Alber, Gottfried
Published in Journal of Immunology (15.01.2006)
Published in Journal of Immunology (15.01.2006)
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Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications
Lim, Jongwon, Altman, Michael D., Baker, James, Brubaker, Jason D., Chen, Hongmin, Chen, Yiping, Kleinschek, Melanie A., Li, Chaomin, Liu, Duan, Maclean, John K.F., Mulrooney, Erin F., Presland, Jeremy, Rakhilina, Larissa, Smith, Graham F., Yang, Ruojing
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system
St Pierre, Cristina, Guo, Jane, Shin, John D, Engstrom, Laura W, Lee, Hyun-Hee, Herbert, Alan, Surdi, Laura, Baker, James, Salmon, Michael, Shah, Sanjiv, Ellis, J Michael, Houshyar, Hani, Crackower, Michael A, Kleinschek, Melanie A, Jones, Dallas C, Hicks, Alexandra, Zaller, Dennis M, Alves, Stephen E, Ramadas, Ravisankar A
Published in PloS one (18.07.2017)
Published in PloS one (18.07.2017)
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Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection
Kleinschek, Melanie A., Müller, Uwe, Schütze, Nicole, Sabat, Robert, Straubinger, Reinhard K., Blumenschein, Wendy M., McClanahan, Terrill, Kastelein, Robert A., Alber, Gottfried
Published in International immunology (01.02.2010)
Published in International immunology (01.02.2010)
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IL25 elicits a multipotent progenitor cell population that promotes T H 2 cytokine responses
Artis, David, Saenz, Steven A, Siracusa, Mark C, Perrigoue, Jacqueline G, Spencer, Sean P, Urban Jr, Joseph F, Tocker, Joel E, Budelsky, Alison L, Kleinschek, Melanie A, Kastelein, Robert A, Kambayashi, Taku, Bhandoola, Avinash
Published in Nature (London) (29.04.2010)
Published in Nature (London) (29.04.2010)
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Journal Article
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses
Saenz, Steven A, Siracusa, Mark C, Perrigoue, Jacqueline G, Spencer, Sean P, Urban, Jr, Joseph F, Tocker, Joel E, Budelsky, Alison L, Kleinschek, Melanie A, Kastelein, Robert A, Kambayashi, Taku, Bhandoola, Avinash, Artis, David
Published in Nature (London) (29.04.2010)
Published in Nature (London) (29.04.2010)
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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
Yen, David, Cheung, Jeanne, Scheerens, Heleen, Poulet, Frédérique, McClanahan, Terrill, McKenzie, Brent, Kleinschek, Melanie A, Owyang, Alex, Mattson, Jeanine, Blumenschein, Wendy, Murphy, Erin, Sathe, Manjiri, Cua, Daniel J, Kastelein, Robert A, Rennick, Donna
Published in The Journal of clinical investigation (01.05.2006)
Published in The Journal of clinical investigation (01.05.2006)
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Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme
Sandborn, William J, Nguyen, Deanna D, Beattie, David T, Brassil, Patrick, Krey, Whitney, Woo, Jacky, Situ, Eva, Sana, Reuben, Sandvik, Erik, Pulido-Rios, M Teresa, Bhandari, Raj, Leighton, Jonathan A, Ganeshappa, Ravi, Boyle, David L, Abhyankar, Brihad, Kleinschek, Melanie A, Graham, Richard A, Panes, Julian
Published in Journal of Crohn's and colitis (16.09.2020)
Published in Journal of Crohn's and colitis (16.09.2020)
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Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation
Smith, Graham F., Altman, Michael D., Andresen, Brian, Baker, James, Brubaker, Jason D., Chen, Hongmin, Chen, Yiping, Childers, Matthew, Donofrio, Anthony, Ferguson, Heidi, Fischer, Christian, Fischmann, Thierry O., Gibeau, Craig, Hicks, Alexander, Jin, Sue, Kattar, Sam, Kleinschek, Melanie A., Leccese, Erica, Lesburg, Charles, Li, Chaomin, Lim, Jongwon, Liu, Duan, Maclean, John K.F., Mansoor, Faruk, Moy, Lilly Y., Mulrooney, Erin F., Necheva, Antoaneta S., Presland, Jeremy, Rakhilina, Larissa, Yang, Ruojing, Torres, Luis, Zhang-Hoover, Jie, Northrup, Alan
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
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IL‐25 exhibits disparate roles during Th2‐cell differentiation versus effector function
Mearns, Helen, Forbes‐Blom, Elizabeth. E., Camberis, Mali, Tang, Shiau‐Choot, Kyle, Ryan, Harvie, Marina, Kleinschek, Melanie A., Gros, Graham Le
Published in European journal of immunology (01.07.2014)
Published in European journal of immunology (01.07.2014)
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Discovery of 5‑Amino‑N‑(1H‑pyrazol-4-yl)pyrazolo[1,5‑a]pyrimidine-3-carboxamide Inhibitors of IRAK4
Lim, Jongwon, Altman, Michael D., Baker, James, Brubaker, Jason D., Chen, Hongmin, Chen, Yiping, Fischmann, Thierry, Gibeau, Craig, Kleinschek, Melanie A., Leccese, Erica, Lesburg, Charles, Maclean, John K. F., Moy, Lily Y., Mulrooney, Erin F., Presland, Jeremy, Rakhilina, Larissa, Smith, Graham F., Steinhuebel, Dietrich, Yang, Ruojing
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Journal Article
IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses
SAENZ, Steven A, SIRACUSA, Mark C, BHANDOOLA, Avinash, ARTIS, David, PERRIGOUE, Jacqueline G, SPENCER, Sean P, URBAN, Joseph F, TOCKER, Joel E, BUDELSKY, Alison L, KLEINSCHEK, Melanie A, KASTELEIN, Robert A, KAMBAYASHI, Taku
Published in Nature (London) (01.04.2010)
Published in Nature (London) (01.04.2010)
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JAK 저해제 화합물의 결정형
KLEINSCHEK MELANIE A, CRATER GLENN D, THALLADI VENKAT R, DABROS MARTA, NZEREM JERRY
Year of Publication 08.01.2020
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Year of Publication 08.01.2020
Patent
융합된 이미다조-피페리딘 JAK 저해제 화합물
BENJAMIN NOAH, MCKINNELL ROBERT MURRAY, KLEINSCHEK MELANIE A, CRATER GLENN D, THALLADI VENKAT R, JIANG LAN, ZHANG HAO, DABROS MARTA, NZEREM JERRY, FATHEREE PAUL R
Year of Publication 26.12.2019
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Year of Publication 26.12.2019
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4-원 헤테로시클릭 아미드를 포함하는 JAK 저해제
SMITH CAMERON, KLEINSCHEK MELANIE A, CRATER GLENN D, SULLIVAN STEVEN D.E, VAN ORDEN LORI JEAN, FATHEREE PAUL R, BRANDT GARY E.L
Year of Publication 13.11.2019
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Year of Publication 13.11.2019
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융합된 이미다조-피페리딘 JAK 저해제
SMITH CAMERON, KLEINSCHEK MELANIE A, CRATER GLENN D, SULLIVAN STEVEN D.E, VAN ORDEN LORI JEAN, FATHEREE PAUL R, BRANDT GARY E.L
Year of Publication 13.11.2019
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Year of Publication 13.11.2019
Patent
In silico and multi-dimensional functional interrogation of tissue Tregs reveals novel therapeutics for autoimmunity and inflammation
Valle, Jose, Guillen, Jovanny, DiMichele, Sarah, Pauli, Mariela, Tan, Corey, Lam, Caroline, Dominguez, Claudia X, Labastida, Rosario, Nganje, Charmaine, Peabody, Phillip, Yan, Hannah, Navas, Ashley, Nishimura, Koki, Yard, Parker, Abraham, Ryan, Meury, Marcel, Aglietti, Robin, Bowers, Peter, McKay, Austin, Taylor, Ian, Eng, Nicolas WL, Mitchell, Keith, Chen, James, Yohn, Christopher B, Astarita, Jillian, Lyons, Jesse, Kleinschek, Melanie A, Zarrin, Ali A
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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