Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic
Reddy, Joseph A., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Kleindl, Paul, Santhapuram, Hari, Vlahov, Iontcho R., Leamon, Christopher P.
Published in Scientific reports (12.06.2018)
Published in Scientific reports (12.06.2018)
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Journal Article
Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate
Vlahov, Iontcho R., Qi, Longwu, Santhapuram, Hari Krishna R., Felten, Albert, Parham, Garth L., Zou, Ning, Wang, Kevin, You, Fei, Vaughn, Jeremy F., Hahn, Spencer J., Klein, Hanna F., Kleindl, Paul J., Reddy, Joe, Reno, Dan, Nicoson, Jeff, Leamon, Christopher P.
Published in Bioorganic & medicinal chemistry letters (01.04.2020)
Published in Bioorganic & medicinal chemistry letters (01.04.2020)
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Journal Article
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide
Vlahov, Iontcho R., Santhapuram, Hari Krishna R., Kleindl, Paul J., Howard, Stephen J., Stanford, Katheryn M., Leamon, Christopher P.
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
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Journal Article
Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates
Vlahov, Iontcho R, Qi, Longwu, Kleindl, Paul J, Santhapuram, Hari K, Felten, Albert, Parham, Garth L, Wang, Kevin, You, Fei, Vaughn, Jeremy F, Hahn, Spencer J, Klein, Hanna F, Vetzel, Marilynn, Reddy, Joseph A, Nelson, Melissa, Nicoson, Jeff, Leamon, Christopher P
Published in Bioconjugate chemistry (20.12.2017)
Published in Bioconjugate chemistry (20.12.2017)
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Journal Article
Preclinical evaluation of EC145, a folate-Vinca alkaloid conjugate
REDDY, Joseph A, DORTON, Ryan, WESTRICK, Elaine, DAWSON, Alicia, SMITH, Terri, XU, Le-Cun, VETZEL, Marilynn, KLEINDL, Paul, VLAHOV, Iontcho R, LEAMON, Christopher P
Published in Cancer research (Chicago, Ill.) (01.05.2007)
Published in Cancer research (Chicago, Ill.) (01.05.2007)
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Journal Article
Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes
Lu, Yingjuan J., Wheeler, Leroy W., Chu, Haiyan, Kleindl, Paul J., Pugh, Michael, You, Fei, Rao, Satish, Garcia, Gabriela, Wu, Henry Y., da Cunha, Andre P., Johnson, Richard, Westrick, Elaine, Cross, Vicky, Lloyd, Alex, Dircksen, Christina, Klein, Patrick J., Vlahov, Iontcho R., Low, Philip S., Leamon, Christopher P.
Published in Cell reports. Medicine (19.10.2021)
Published in Cell reports. Medicine (19.10.2021)
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Journal Article
Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus
Lu, Yingjuan, Parker, Nikki, Kleindl, Paul J, Cross, Vicky A, Wollak, Kristin, Westrick, Elaine, Stinnette, Torian W, Gehrke, Mark A, Wang, Kevin, Santhapuram, Hari Krishna R, You, Fei, Hahn, Spencer J, Vaughn, Jeremy F, Klein, Patrick J, Vlahov, Iontcho R, Low, Philip S, Leamon, Christopher P
Published in Molecular medicine (Cambridge, Mass.) (08.07.2015)
Published in Molecular medicine (Cambridge, Mass.) (08.07.2015)
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Journal Article
Carbohydrate-Based Synthetic Approach to Control Toxicity Profiles of Folate−Drug Conjugates
Vlahov, Iontcho R, Santhapuram, Hari Krishna R, You, Fei, Wang, Yu, Kleindl, Paul J, Hahn, Spencer J, Vaughn, Jeremy F, Reno, Daniel S, Leamon, Christopher P
Published in Journal of organic chemistry (04.06.2010)
Published in Journal of organic chemistry (04.06.2010)
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Journal Article
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides
Vlahov, Iontcho R., Wang, Yu, Kleindl, Paul J., Leamon, Christopher P.
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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Journal Article
Acid mediated formation of an N-acyliminium ion from tubulysins: A new methodology for the synthesis of natural tubulysins and their analogs
Vlahov, Iontcho R., Wang, Yu, Vetzel, Marilynn, Hahn, Spencer, Kleindl, Paul J., Reddy, Joseph A., Leamon, Christopher P.
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
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Journal Article
Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid
Vlahov, Iontcho R., Vite, Gregory D., Kleindl, Paul J., Wang, Yu, Santhapuram, Hari Krishna R., You, Fei, Howard, Stephen J., Kim, Soong-Hoon, Lee, Francis F.Y., Leamon, Christopher P.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
An Assembly Concept for the Consecutive Introduction of Unsymmetrical Disulfide Bonds: Synthesis of a Releasable Multidrug Conjugate of Folic Acid
Vlahov, Iontcho R, Santhapuram, Hari Krishna R, Wang, Yu, Kleindl, Paul J, You, Fei, Howard, Stephen J, Westrick, Elaine, Reddy, Joseph A, Leamon, Christopher P
Published in Journal of organic chemistry (03.08.2007)
Published in Journal of organic chemistry (03.08.2007)
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Journal Article
Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation
Vlahov, Iontcho R., You, Fei, Santhapuram, Hari Krishna R., Wang, Yu, Vaughn, Jeremy F., Hahn, Spencer J., Kleindl, Paul J., Fan, Mingjin, Leamon, Christopher P.
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
Published in Bioorganic & medicinal chemistry letters (15.02.2011)
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Journal Article
Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate
Leamon, Christopher P, Reddy, Joseph A, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Vetzel, Marilynn, Kleindl, Paul, Hahn, Spencer, Wang, Kevin, Vlahov, Iontcho R
Published in Bioconjugate chemistry (19.06.2019)
Published in Bioconjugate chemistry (19.06.2019)
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Journal Article
Abstract 757: Novel warheads for targeted therapies of cancer: The concept and design of oxime-ether-based pro-PBDs
Vlahov, Iontcho, Felten, Albert, Zou, Ning, Wang, Kevin, Santhapuram, Hari K., Kleindl, Paul, Hahn, Spencer, Vaughn, Jeremy, Leamon, Christopher
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 4735: Designing novel warheads for targeted therapies: SAR and efficient strategies for the synthesis of analogues of tubulysin
Vlahov, Iontcho, You, Fei, Kleindl, Paul, Vetzel, Marilynn, Reddy, Joseph, Leamon, Christopher
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 5147: Novel warheads for targeted therapies of cancer: The concept and design of proPBDs
Vlahov, Iontcho, Qi, Longwu, Hahn, Spencer, Wang, Kevin, Santhapuram, Hari K., Felten, Albert, Kleindl, Paul, Vaughn, Jeremy, Leamon, Christopher P.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Folate–Vinca Alkaloid Conjugates for Cancer Therapy: A Structure–Activity Relationship
Leamon, Christopher P, Vlahov, Iontcho R, Reddy, Joseph A, Vetzel, Marilynn, Santhapuram, Hari Krishna R, You, Fei, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Kleindl, Paul, Vaughn, Jeremy F, Westrick, Elaine
Published in Bioconjugate chemistry (19.03.2014)
Published in Bioconjugate chemistry (19.03.2014)
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