Development and characterization of NILK-2301, a novel CEACAM5xCD3 κλ bispecific antibody for immunotherapy of CEACAM5-expressing cancers
Seckinger, Anja, Majocchi, Sara, Moine, Valéry, Nouveau, Lise, Ngoc, Hoang, Daubeuf, Bruno, Ravn, Ulla, Pleche, Nicolas, Calloud, Sebastien, Broyer, Lucile, Cons, Laura, Lesnier, Adeline, Chatel, Laurence, Papaioannou, Anne, Salgado-Pires, Susana, Krämer, Sebastian, Gockel, Ines, Lordick, Florian, Masternak, Krzysztof, Poitevin, Yves, Magistrelli, Giovanni, Malinge, Pauline, Shang, Limin, Kallendrusch, Sonja, Strein, Klaus, Hose, Dirk
Published in Journal of hematology and oncology (12.12.2023)
Published in Journal of hematology and oncology (12.12.2023)
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Journal Article
Target Expression, Generation, Preclinical Activity, and Pharmacokinetics of the BCMA-T Cell Bispecific Antibody EM801 for Multiple Myeloma Treatment
Seckinger, Anja, Delgado, Jose Antonio, Moser, Samuel, Moreno, Laura, Neuber, Brigitte, Grab, Anna, Lipp, Susanne, Merino, Juana, Prosper, Felipe, Emde, Martina, Delon, Camille, Latzko, Melanie, Gianotti, Reto, Lüoend, Remo, Murr, Ramona, Hosse, Ralf J., Harnisch, Lydia Jasmin, Bacac, Marina, Fauti, Tanja, Klein, Christian, Zabaleta, Aintzane, Hillengass, Jens, Cavalcanti-Adam, Elisabetta Ada, Ho, Anthony D., Hundemer, Michael, San Miguel, Jesus F., Strein, Klaus, Umaña, Pablo, Hose, Dirk, Paiva, Bruno, Vu, Minh Diem
Published in Cancer cell (13.03.2017)
Published in Cancer cell (13.03.2017)
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Journal Article
Development and characterization of NILK-2301, a novel CEACAM5xCD3 κ[lambda] bispecific antibody for immunotherapy of CEACAM5-expressing cancers
Seckinger, Anja, Majocchi, Sara, Moine, Valéry, Nouveau, Lise, Ngoc, Hoang, Daubeuf, Bruno, Ravn, Ulla, Pleche, Nicolas, Calloud, Sebastien, Broyer, Lucile, Cons, Laura, Lesnier, Adeline, Chatel, Laurence, Papaioannou, Anne, Salgado-Pires, Susana, Krämer, Sebastian, Gockel, Ines, Lordick, Florian, Masternak, Krzysztof, Poitevin, Yves, Magistrelli, Giovanni, Malinge, Pauline, Shang, Limin, Kallendrusch, Sonja, Strein, Klaus, Hose, Dirk
Published in Journal of hematology and oncology (12.12.2023)
Published in Journal of hematology and oncology (12.12.2023)
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Journal Article
Abstract 5100: Combination of κλ bispecific antibodies targeting innate (CEAxCD47, NILK-2401) and adaptive immunity (CEAxCD3, NILK-2301 and CEAxCD28, NILK-3301) for next generation immunotherapy of CEA-expressing cancers
Seckinger, Anja, Nouveau, Lise, Majocchi, Sara, Moine, Valéry, Buatois, Vanessa, Daubeuf, Bruno, Gueneau, Franck, Ravn, Ulla, Masternak, Krzysztof, Poitevin, Yves, Rousset, Emeline, Magistrelli, Giovanni, Malinge, Pauline, Shang, Limin, Fischer, Nicolas, Strein, Klaus, Ferlin, Walter, Hose, Dirk
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
New Insights into the Mechanism of Action (MoA) of First-in-Class IgG-Based Bcma T-Cell Bispecific Antibody (TCB) for the Treatment of Multiple Myeloma (MM)
Moreno, Laura, Zabaleta, Aintzane, Alignani, Diego, Lasa, Marta, Maiso, Patricia, Jelinek, Tomas, Segura, Victor, Delgado, Jose Antonio, Rodriguez-Otero, Paula, Prosper, Felipe, Strein, Klaus, Vu, Minh Diem, San Miguel, Jesus, Paiva, Bruno
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Target Expression, Preclinical Activity and Mechanism of Action of EM801: A Novel First-in-Class Bcma T-Cell Bispecific Antibody for the Treatment of Multiple Myeloma
Seckinger, Anja, Delgado, Jose Antonio, Moreno, Laura, Neuber, Brigitte, Grab, Anna, Lipp, Susanne, Merino, Juana, Vu, Minh Diem, Strein, Klaus, Prosper, Felipe, Hundemer, Michael, San Miguel, Jesus, Hose, Dirk, Paiva, Bruno
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
A New Class of T-Cell Bispecific Antibodies for the Treatment of Multiple Myeloma, Binding to B Cell Maturation Antigen and CD3 and Showing Potent, Specific Antitumor Activity in Myeloma Cells and Long Duration of Action in Cynomolgus Monkeys
Vu, Minh Diem, Moser, Samuel, Delon, Camille, Latzko, Melanie, Gianotti, Reto, Lüoend, Remo, Friang, Chloé, Murr, Ramona, Duerner, Lydia Jasmin, Weinzierl, Tina, Fauti, Tanja, Bacac, Marina, Ast, Oliver, Freimoser-Grundschober, Anne, Rodriguez Diaz, Tea, Zielonka, Jörg, van Puijenbroek, Erwin, Hosse, Ralf, Bruenker, Peter, Mössner, Ekkehard, Klein, Christian, Umaña, Pablo, Strein, Klaus
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
BISPECIFIC ANTIBODIES AGAINST CD3ε AND BCMA
AST OLIVER, TANJA FAUTI, MESSNER EKKEHARD, KLEIN CHRISTIAN, ANNE FREIMOSER-GRUNDSCHOBER, SAMUEL MOSER, MARINA BACAC, RALF HOSSE, MINH DIEM VU, PABLO UMANA, KLAUS STREIN
Year of Publication 05.11.2020
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Year of Publication 05.11.2020
Patent
METHOD FOR SELECTION OF ANTIBODIES AGAINST BCMA
AST OLIVER, TANJA FAUTI, MESSNER EKKEHARD, KLEIN CHRISTIAN, ANNE FREIMOSER-GRUNDSCHOBER, SAMUEL MOSER, MARINA BACAC, RALF HOSSE, MINH DIEM VU, PABLO UMANA, KLAUS STREIN
Year of Publication 13.02.2020
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Year of Publication 13.02.2020
Patent
MONOCLONAL ANTIBODIES AGAINST BCMA
AST OLIVER, MESSNER EKKEHARD, KLEIN CHRISTIAN, ANNE FREIMOSER-GRUNDSCHOBER, SAMUEL MOSER, MARINA BACAC, MINH DIEM VU, PABLO UMANA, TINA WEINZIERL, KLAUS STREIN, CAMILLE DELON, JASMIN DUERNER LYDIA
Year of Publication 16.07.2020
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Year of Publication 16.07.2020
Patent
BISPECIFIC ANTIBODIES AGAINST CD3EPSILON AND BCMA
MESSNER EKKEHARD, ANNE FREIMOSER-GRUNDSCHOBER, JOERG REGULA, MINH DIEM VU, LYDIA JASMIN HANISCH, AST OLIVER, TANJA FAUTI, SABINE JUNG-IMHOF, KLEIN CHRISTIAN, STEFAN KLOSTERMANN, MICHAEL MOLHOJ, SAMUEL MOSER, MARINA BACAC, RAMONA MURR, RALF HOSSE, SCHAEFER WOLFGANG, PABLO UMANA, KLAUS STREIN
Year of Publication 13.08.2020
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Year of Publication 13.08.2020
Patent