Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells
Schröder, Ralf, Schmidt, Johannes, Blättermann, Stefanie, Peters, Lucas, Janssen, Nicole, Grundmann, Manuel, Seemann, Wiebke, Kaufel, Dorina, Merten, Nicole, Drewke, Christel, Gomeza, Jesus, Milligan, Graeme, Mohr, Klaus, Kostenis, Evi
Published in Nature protocols (01.11.2011)
Published in Nature protocols (01.11.2011)
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Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements
Mohr, Klaus, Kostenis, Evi, Schröder, Ralf, Janssen, Nicole, Schmidt, Johannes, Kebig, Anna, Merten, Nicole, Hennen, Stephanie, Müller, Anke, Blättermann, Stefanie, Mohr-Andrä, Marion, Zahn, Sabine, Wenzel, Jörg, Smith, Nicola J, Gomeza, Jesús, Drewke, Christel, Milligan, Graeme
Published in Nature biotechnology (01.09.2010)
Published in Nature biotechnology (01.09.2010)
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The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling
Bock, Andreas, Merten, Nicole, Schrage, Ramona, Dallanoce, Clelia, Bätz, Julia, Klöckner, Jessica, Schmitz, Jens, Matera, Carlo, Simon, Katharina, Kebig, Anna, Peters, Lucas, Müller, Anke, Schrobang-Ley, Jasmin, Tränkle, Christian, Hoffmann, Carsten, De Amici, Marco, Holzgrabe, Ulrike, Kostenis, Evi, Mohr, Klaus
Published in Nature communications (04.09.2012)
Published in Nature communications (04.09.2012)
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Rational design of dualsteric GPCR ligands: quests and promise
Mohr, Klaus, Tränkle, Christian, Kostenis, Evi, Barocelli, Elisabetta, De Amici, Marco, Holzgrabe, Ulrike
Published in British journal of pharmacology (01.03.2010)
Published in British journal of pharmacology (01.03.2010)
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Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation
Merten, Nicole, Fischer, Julia, Simon, Katharina, Zhang, Liguo, Schröder, Ralf, Peters, Lucas, Letombe, Anne-Gaelle, Hennen, Stephanie, Schrage, Ramona, Bödefeld, Theresa, Vermeiren, Celine, Gillard, Michel, Mohr, Klaus, Lu, Qing Richard, Brüstle, Oliver, Gomeza, Jesus, Kostenis, Evi
Published in Cell chemical biology (21.06.2018)
Published in Cell chemical biology (21.06.2018)
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Dynamic ligand binding dictates partial agonism at a G protein–coupled receptor
Bock, Andreas, Chirinda, Brian, Krebs, Fabian, Messerer, Regina, Bätz, Julia, Muth, Mathias, Dallanoce, Clelia, Klingenthal, Dominika, Tränkle, Christian, Hoffmann, Carsten, De Amici, Marco, Holzgrabe, Ulrike, Kostenis, Evi, Mohr, Klaus
Published in Nature chemical biology (01.01.2014)
Published in Nature chemical biology (01.01.2014)
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Rational Design of Partial Agonists for the Muscarinic M1 Acetylcholine Receptor
Chen, Xinyu, Klöckner, Jessika, Holze, Janine, Zimmermann, Cornelia, Seemann, Wiebke K, Schrage, Ramona, Bock, Andreas, Mohr, Klaus, Tränkle, Christian, Holzgrabe, Ulrike, Decker, Michael
Published in Journal of medicinal chemistry (22.01.2015)
Published in Journal of medicinal chemistry (22.01.2015)
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Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity
Antony, Johannes, Kellershohn, Kerstin, Mohr-Andrä, Marion, Kebig, Anna, Prilla, Stefanie, Muth, Mathias, Heller, Eberhard, Disingrini, Teresa, Dallanoce, Clelia, Bertoni, Simona, Schrobang, Jasmin, Tränkle, Christian, Kostenis, Evi, Christopoulos, Arthur, Höltje, Hans-Dieter, Barocelli, Elisabetta, De Amici, Marco, Holzgrabe, Ulrike, Mohr, Klaus
Published in The FASEB journal (01.02.2009)
Published in The FASEB journal (01.02.2009)
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Hybrid Molecules from Xanomeline and Tacrine: Enhanced Tacrine Actions on Cholinesterases and Muscarinic M1 Receptors
Fang, Lei, Jumpertz, Sabine, Zhang, Yihua, Appenroth, Dorothea, Fleck, Christian, Mohr, Klaus, Tränkle, Christian, Decker, Michael
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Journal Article
Ligand-Specific Allosteric Coupling Controls G‑Protein-Coupled Receptor Signaling
Holze, Janine, Bermudez, Marcel, Pfeil, Eva Marie, Kauk, Michael, Bödefeld, Theresa, Irmen, Matthias, Matera, Carlo, Dallanoce, Clelia, De Amici, Marco, Holzgrabe, Ulrike, König, Gabriele Maria, Tränkle, Christian, Wolber, Gerhard, Schrage, Ramona, Mohr, Klaus, Hoffmann, Carsten, Kostenis, Evi, Bock, Andreas
Published in ACS pharmacology & translational science (09.10.2020)
Published in ACS pharmacology & translational science (09.10.2020)
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Allosteric Small Molecules Unveil a Role of an Extracellular E2/Transmembrane Helix 7 Junction for G Protein-coupled Receptor Activation
Jäger, Dorothea, Schmalenbach, Caroline, Prilla, Stefanie, Schrobang, Jasmin, Kebig, Anna, Sennwitz, Matthias, Heller, Eberhard, Tränkle, Christian, Holzgrabe, Ulrike, Höltje, Hans-Dieter, Mohr, Klaus
Published in The Journal of biological chemistry (30.11.2007)
Published in The Journal of biological chemistry (30.11.2007)
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Allosteric Site on Muscarinic Acetylcholine Receptors: Identification of Two Amino Acids in the Muscarinic M2 Receptor That Account Entirely for the M2/M5 Subtype Selectivities of Some Structurally Diverse Allosteric Ligands in N-Methylscopolamine-Occupied Receptors
Voigtländer, Uta, Jöhren, Kirstin, Mohr, Marion, Raasch, Alexandra, Tränkle, Christian, Buller, Stefan, Ellis, John, Höltje, Hans-Dieter, Mohr, Klaus
Published in Molecular pharmacology (01.07.2003)
Published in Molecular pharmacology (01.07.2003)
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Interactions of Orthosteric and Allosteric Ligands with [3H]Dimethyl-W84 at the Common Allosteric Site of Muscarinic M2 Receptors
Tränkle, Christian, Weyand, Oliver, Voigtländer, Uta, Mynett, Anita, Lazareno, Sebastian, Birdsall, Nigel J M, Mohr, Klaus
Published in Molecular pharmacology (01.07.2003)
Published in Molecular pharmacology (01.07.2003)
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A hydrazide linker strategy for heterobivalent compounds as ortho- and allosteric ligands of acetylcholine-binding proteins
Elsinghorst, Paul W, Härtig, Wolfgang, Gündisch, Daniela, Mohr, Klaus, Tränkle, Christian, Gütschow, Michael
Published in Current topics in medicinal chemistry (01.11.2011)
Published in Current topics in medicinal chemistry (01.11.2011)
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Allosteric Site on Muscarinic Acetylcholine Receptors: A Single Amino Acid in Transmembrane Region 7 Is Critical to the Subtype Selectivities of Caracurine V Derivatives and Alkane-Bisammonium Ligands
Buller, Stefan, Zlotos, Darius Paul, Mohr, Klaus, Ellis, John
Published in Molecular pharmacology (01.01.2002)
Published in Molecular pharmacology (01.01.2002)
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Allosteric Modulation of Muscarinic Receptor Signaling: Alcuronium-Induced Conversion of Pilocarpine from an Agonist into an Antagonist
Katrin Zahn, Niels Eckstein, Christian Tränkle, Wolfgang Sadée, Klaus Mohr
Published in The Journal of pharmacology and experimental therapeutics (01.05.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2002)
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Journal Article
Using a Radioalloster to Test Predictions of the Cooperativity Model for Gallamine Binding to the Allosteric Site of Muscarinic Acetylcholine M2 Receptors
Christian Tränkle, Oliver Weyand, Alexandra Schröter, Klaus Mohr
Published in Molecular pharmacology (01.11.1999)
Published in Molecular pharmacology (01.11.1999)
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