Rational Design of Partial Agonists for the Muscarinic M-1 Acetylcholine Receptor
Chen, Xinyu, Kloeckner, Jessika, Holze, Janine, Zimmermann, Cornelia, Seemann, Wiebke K., Schrage, Ramona, Bock, Andreas, Mohr, Klaus, Traenkle, Christian, Holzgrabe, Ulrike, Decker, Michael
Published in Journal of medicinal chemistry (22.01.2015)
Published in Journal of medicinal chemistry (22.01.2015)
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Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors
Matucci, Rosanna, Bellucci, Cristina, Martino, Maria Vittoria, Nesi, Marta, Manetti, Dina, Welzel, Jessica, Bartz, Ulrike, Holze, Janine, Tränkle, Christian, Mohr, Klaus, Mazzolari, Angelica, Vistoli, Giulio, Dei, Silvia, Teodori, Elisabetta, Romanelli, Maria Novella
Published in European journal of pharmacology (15.09.2020)
Published in European journal of pharmacology (15.09.2020)
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Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist
Hennen, Stephanie, Wang, Haibo, Peters, Lucas, Merten, Nicole, Simon, Katharina, Spinrath, Andreas, Blättermann, Stefanie, Akkari, Rhalid, Schrage, Ramona, Schröder, Ralf, Schulz, Daniel, Vermeiren, Celine, Zimmermann, Katrin, Kehraus, Stefan, Drewke, Christel, Pfeifer, Alexander, König, Gabriele M, Mohr, Klaus, Gillard, Michel, Müller, Christa E, Lu, Q Richard, Gomeza, Jesus, Kostenis, Evi
Published in Science signaling (22.10.2013)
Published in Science signaling (22.10.2013)
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The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes
Simon, Katharina, Merten, Nicole, Schröder, Ralf, Hennen, Stephanie, Preis, Philip, Schmitt, Nina-Katharina, Peters, Lucas, Schrage, Ramona, Vermeiren, Celine, Gillard, Michel, Mohr, Klaus, Gomeza, Jesus, Kostenis, Evi
Published in Molecular pharmacology (01.05.2017)
Published in Molecular pharmacology (01.05.2017)
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Ligand-Specific Restriction of Extracellular Conformational Dynamics Constrains Signaling of the M2 Muscarinic Receptor
Bermudez, Marcel, Bock, Andreas, Krebs, Fabian, Holzgrabe, Ulrike, Mohr, Klaus, Lohse, Martin J, Wolber, Gerhard
Published in ACS chemical biology (21.07.2017)
Published in ACS chemical biology (21.07.2017)
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A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor
Grundmann, Manuel, Tikhonova, Irina G., Hudson, Brian D., Smith, Nicola J., Mohr, Klaus, Ulven, Trond, Milligan, Graeme, Kenakin, Terry, Kostenis, Evi
Published in Cell chemical biology (17.03.2016)
Published in Cell chemical biology (17.03.2016)
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A muscarinic view on Gq
Mohr, Klaus, Tränkle, Christian
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.11.2013)
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.11.2013)
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A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer
Blättermann, Stefanie, Peters, Lucas, Ottersbach, Philipp Aaron, Bock, Andreas, Konya, Viktoria, Weaver, C David, Gonzalez, Angel, Schröder, Ralf, Tyagi, Rahul, Luschnig, Petra, Gäb, Jürgen, Hennen, Stephanie, Ulven, Trond, Pardo, Leonardo, Mohr, Klaus, Gütschow, Michael, Heinemann, Akos, Kostenis, Evi
Published in Nature chemical biology (01.07.2012)
Published in Nature chemical biology (01.07.2012)
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Dualsteric Muscarinic Antagonists–Orthosteric Binding Pose Controls Allosteric Subtype Selectivity
Schmitz, Jens, van der Mey, Dorina, Bermudez, Marcel, Klöckner, Jessica, Schrage, Ramona, Kostenis, Evi, Tränkle, Christian, Wolber, Gerhard, Mohr, Klaus, Holzgrabe, Ulrike
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Hybrid Molecules from Xanomeline and Tacrine: Enhanced Tacrine Actions on Cholinesterases and Muscarinic M-1 Receptors
Fang, Lei, Jumpertz, Sabine, Zhang, Yihua, Appenroth, Dorothea, Fleck, Christian, Mohr, Klaus, Traenkle, Christian, Decker, Michael
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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A New Molecular Mechanism To Engineer Protean Agonism at a G Protein-Coupled Receptor
De Min, Anna, Matera, Carlo, Bock, Andreas, Holze, Janine, Kloeckner, Jessica, Muth, Mathias, Traenkle, Christian, De Amici, Marco, Kenakin, Terry, Holzgrabe, Ulrike, Dallanoce, Clelia, Kostenis, Evi, Mohr, Klaus, Schrage, Ramona
Published in Molecular pharmacology (01.04.2017)
Published in Molecular pharmacology (01.04.2017)
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Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: Synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity
Matera, Carlo, Flammini, Lisa, Quadri, Marta, Vivo, Valentina, Ballabeni, Vigilio, Holzgrabe, Ulrike, Mohr, Klaus, De Amici, Marco, Barocelli, Elisabetta, Bertoni, Simona, Dallanoce, Clelia
Published in European journal of medicinal chemistry (21.03.2014)
Published in European journal of medicinal chemistry (21.03.2014)
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Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice
Keller, Kirsten, Maass, Martina, Dizayee, Sara, Leiss, Veronika, Annala, Suvi, Köth, Jessica, Seemann, Wiebke K, Müller-Ehmsen, Jochen, Mohr, Klaus, Nürnberg, Bernd, Engelhardt, Stefan, Herzig, Stefan, Birnbaumer, Lutz, Matthes, Jan
Published in Cardiovascular research (01.12.2015)
Published in Cardiovascular research (01.12.2015)
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New insight into active muscarinic receptors with the novel radioagonist [3H]iperoxo
Schrage, Ramona, Holze, Janine, Klöckner, Jessica, Balkow, Aileen, Klause, Anne S., Schmitz, Anna-Lena, De Amici, Marco, Kostenis, Evi, Tränkle, Christian, Holzgrabe, Ulrike, Mohr, Klaus
Published in Biochemical pharmacology (01.08.2014)
Published in Biochemical pharmacology (01.08.2014)
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Engineered Context-Sensitive Agonism: Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor
Seemann, Wiebke K, Wenzel, Daniela, Schrage, Ramona, Etscheid, Justine, Bödefeld, Theresa, Bartol, Anna, Warnken, Mareille, Sasse, Philipp, Klöckner, Jessica, Holzgrabe, Ulrike, DeAmici, Marco, Schlicker, Eberhard, Racké, Kurt, Kostenis, Evi, Meyer, Rainer, Fleischmann, Bernd K, Mohr, Klaus
Published in The Journal of pharmacology and experimental therapeutics (01.02.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2017)
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